(Q38311322)

2 September 2017

1 reference

title

Halofuginone - the multifaceted molecule (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272571&resulttype=core&format=json

13 May 2020

author name string

Mark Pines

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272571&resulttype=core&format=json

13 May 2020

Itai Spector

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272571&resulttype=core&format=json

13 May 2020

language of work or name

English

0 references

publication date

5 January 2015

1 reference

2 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272571&resulttype=core&format=json

13 May 2020

volume

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272571&resulttype=core&format=json

13 May 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272571&resulttype=core&format=json

13 May 2020

page(s)

573-594

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272571&resulttype=core&format=json

Creative Commons Attribution 4.0 International

13 May 2020

copyright license

start time

5 January 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Target identification for small bioactive molecules: finding the needle in the haystack

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Pharmacology of ch'ang shan (Dichroa febrifuga) a Chinese antimalarial herb.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

The role of plant-derived drugs and herbal medicines in healthcare

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Antimalarial activities and therapeutic properties of febrifugine analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Synthesis and antimalarial evaluation of some 4-quinazolinone derivatives based on febrifugine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Exploration of a new type of antimalarial compounds based on febrifugine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Pharmacophore modeling and 3D quantitative structure-activity relationship analysis of febrifugine analogues as potent antimalarial agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Catalytic Asymmetric Synthesis of Antimalarial Alkaloids Febrifugine and Isofebrifugine and Their Biological Activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Synthesis and comparison of antimalarial activity of febrifugine derivatives including halofuginone

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Dihydroxylation of vinyl sulfones: stereoselective synthesis of (+)- and (-)-febrifugine and halofuginone

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Re-revision of the stereo structure of piperidine lactone, an intermediate in the synthesis of febrifugine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

The chemistry and biology of febrifugine and halofuginone

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Characterization of Plasmodium liver stage inhibition by halofuginone

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Milestones in avian coccidiosis research: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Eimeriosis in cattle: current understanding

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Systematic review and meta-analyses of the effects of halofuginone against calf cryptosporidiosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Evaluation of anticoccidial drugs in chicken embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Treatment of calf diarrhea: antimicrobial and ancillary treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Control of cryptosporidiosis in neonatal calves: use of halofuginone lactate in two different calf rearing systems

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Effect of halofuginone lactate on treatment and prevention of lamb cryptosporidiosis: an extensive field trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Combination of cell culture and quantitative PCR for screening of drugs against Cryptosporidium parvum

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

(2R,3S)-(+)- and (2S,3R)-(-)-Halofuginone lactate: synthesis, absolute configuration, and activity against Cryptosporidium parvum

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone: a novel antifibrotic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone for fibrosis, regeneration and cancer in the gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Reduction in dermal fibrosis in the tight-skin (Tsk) mouse after local application of halofuginone

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone, an inhibitor of collagen synthesis by rat stellate cells, stimulates insulin-like growth factor binding protein-1 synthesis by hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Inhibition of matrix metalloproteinase-2 by halofuginone is mediated by the Egr1 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Transforming growth factor-β signalling: role and consequences of Smad linker region phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginone

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Gene expression during chemically induced liver fibrosis: effect of halofuginone on TGF-beta signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone inhibits Smad3 phosphorylation via the PI3K/Akt and MAPK/ERK pathways in muscle cells: effect on myotube fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Involvement of host stroma cells and tissue fibrosis in pancreatic tumor development in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone stimulates adaptive remodeling and preserves re-endothelialization in balloon-injured rat carotid arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Fibrosis inhibition and muscle histopathology improvement in laminin-alpha2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Myofibroblasts in pulmonary and brain metastases of alveolar soft-part sarcoma: a novel target for treatment?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone: a potent inhibitor of critical steps in angiogenesis progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Inhibition of neovascularization and tumor growth, and facilitation of wound repair, by halofuginone, an inhibitor of collagen type I synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Inhibition of Wilms tumor xenograft progression by halofuginone is accompanied by activation of WT-1 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Type I collagen expression contributes to angiogenesis and the development of deeply invasive cutaneous melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Inhibition of pancreatic stellate cell activation by halofuginone prevents pancreatic xenograft tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Growth inhibition of prostate cancer xenografts by halofuginone

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone inhibits the establishment and progression of melanoma bone metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Regulated cell death: signaling and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

The antifibrotic drug halofuginone inhibits proliferation and collagen production by human leiomyoma and myometrial smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone inhibits multiple myeloma growth in vitro and in vivo and enhances cytotoxicity of conventional and novel agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone suppresses T cell proliferation by blocking proline uptake and inducing cell apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone improves muscle-cell survival in muscular dystrophies.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Th17 cells in inflammation and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Interleukin-17 in human inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Th17 cells and IL-17 in protective immunity to vaginal candidiasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone prevents estrogen-deficient osteoporosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

IL-17RC: a partner in IL-17 signaling and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

SMAD regulatory networks construct a balanced immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Stromal cells induce Th17 during Helicobacter pylori infection and in the gastric tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

The effect of antifibrotic drug halofugine on Th17 cells in concanavalin A-induced liver fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Plasmodium falciparum: studies on mature exoerythrocytic forms in the liver of the chimpanzee, Pan troglodytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Specific inflammatory cell infiltration of hepatic schizonts in BALB/c mice immunized with attenuated Plasmodium yoelii sporozoites

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Prediction of fibrosis progression in chronic viral hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Phase II AIDS Malignancy Consortium trial of topical halofuginone in AIDS-related Kaposi sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Phase I and pharmacokinetic study of halofuginone, an oral quinazolinone derivative in patients with advanced solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone inhibits NF-kappaB and p38 MAPK in activated T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES20010573

Halofuginone, an inhibitor of collagen type I synthesis, prevents postoperative adhesion formation in the rat uterine horn model

21 January 2018

1 reference

12 December 2020

Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone

1 reference

12 December 2020

Topical treatment of cutaneous chronic graft versus host disease with halofuginone: a novel inhibitor of collagen type I synthesis

1 reference

12 December 2020

A diastereocontrolled synthesis of (+)-febrifugine: a potent antimalarial piperidine alkaloid

1 reference

12 December 2020

The effect of halofuginone, an inhibitor of collagen type i synthesis, on urethral stricture formation: in vivo and in vitro study in a rat model

1 reference

12 December 2020

Studies in human malaria. XXV. Trial of febrifugine, an alkaloid obtained from Dichroa febrifuga lour., against the Chesson strain of Plasmodium vivax

1 reference

12 December 2020

Pathogenicity and control of Eimeria mitis infections in broiler chickens

1 reference

12 December 2020

Inhibition of fibroblast to myofibroblast transition by halofuginone contributes to the chemotherapy-mediated antitumoral effect

1 reference

12 December 2020

Transforming growth factor-beta and fibrosis

1 reference

12 December 2020

Preventive and therapeutic efficacy of halofuginone-lactate against Cryptosporidium parvum in spontaneously infected calves: a centralised, randomised, double-blind, placebo-controlled study

1 reference

12 December 2020

Ch'ang Shan, a Chinese Antimalarial Herb

1 reference

12 December 2020

Alkaloids of Dichroa febrifuga; isolation and degradative studies

1 reference

12 December 2020

Alkaloids of Dichroa febrifuga Lour

1 reference

12 December 2020

An alkaloid with high antimalarial activity from Dichroa febrifuga

1 reference

12 December 2020

[Helper (TH1, TH2, TH17) and regulatory cells (Treg, TH3, NKT) in rheumatoid arthritis]

1 reference

12 December 2020

Halofuginone down-regulates Smad3 expression and inhibits the TGFbeta-induced expression of fibrotic markers in human corneal fibroblasts

1 reference

12 December 2020

Anticoccidial effect of halofuginone hydrobromide against Eimeria tenella with associated histology

1 reference

12 December 2020

Halofugine prevents cutaneous graft versus host disease by suppression of Th17 differentiation

1 reference

12 December 2020

Inhibition of muscle fibrosis and improvement of muscle histopathology in dysferlin knock-out mice treated with halofuginone

1 reference

12 December 2020

Targeting TGFβ signaling to inhibit fibroblast activation as a therapy for fibrosis and cancer: effect of halofuginone

1 reference

12 December 2020

Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase-9.

1 reference

12 December 2020

Synthesis of febrifugine derivatives and development of an effective and safe tetrahydroquinazoline-type antimalarial

1 reference

12 December 2020

Halofuginone ameliorates autoimmune arthritis in mice by regulating the balance between Th17 and Treg cells and inhibiting osteoclastogenesis

1 reference

12 December 2020

Stage specific actions of antimalarial drugs on Plasmodium falciparum in culture

1 reference

12 December 2020

Anticoccidial evaluation of halofuginone, lasalocid, maduramicin, monensin and salinomycin

1 reference

12 December 2020

Febrifugine antimalarial agents. I. Pyridine analogs of febrifugine

1 reference

12 December 2020

Structural modification of febrifugine. Some methylenedioxy analogs

1 reference

12 December 2020

The effects of halofuginone and salinomycin, alone and in combination, on live performance and skin characteristics of broilers

1 reference

12 December 2020

Specific serum and local antibody responses against Cryptosporidium parvum during medication of calves with halofuginone lactate.

1 reference

12 December 2020

Induction of hepatic inflammatory response by Plasmodium berghei sporozoites protects BALB/c mice against challenge with Plasmodium yoelii sporozoites.

1 reference

12 December 2020

Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: effect of halofuginone

1 reference

12 December 2020

Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: effect of halofuginone

1 reference

12 December 2020

Reduction in pulmonary fibrosis in vivo by halofuginone

1 reference

12 December 2020

Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis

1 reference

12 December 2020

Halofuginone--an inhibitor of collagen type I synthesis--prevents postoperative formation of abdominal adhesions

1 reference

12 December 2020

10.3390/MOLECULES20010573

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272571&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272571&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6272571&resulttype=core&format=json