(Q38313725)

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siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts.

scientific article published on May 2006

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20 January 2020

siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts (English)

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20 January 2020

Olaf Heidenreich

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20 January 2020

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J Dunne

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20 January 2020

C Cullmann

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20 January 2020

M Ritter

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20 January 2020

N Martinez Soria

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20 January 2020

B Drescher

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20 January 2020

S Debernardi

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20 January 2020

S Skoulakis

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20 January 2020

O Hartmann

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20 January 2020

M Krause

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20 January 2020

J Krauter

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20 January 2020

A Neubauer

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20 January 2020

B D Young

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20 January 2020

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1 May 2006

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20 January 2020

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20 January 2020

25

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20 January 2020

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20 January 2020

6067-6078

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20 January 2020

Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

1 reference

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21 January 2018

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain

1 reference

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21 January 2018

AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiation

1 reference

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21 January 2018

BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B Study

1 reference

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21 January 2018

NCBI GEO: mining millions of expression profiles--database and tools

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21 January 2018

Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

1 reference

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21 January 2018

Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation

1 reference

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21 January 2018

Genome‐wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation‐mediated fusion events

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21 January 2018

Human HTm4 is a hematopoietic cell cycle regulator

1 reference

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21 January 2018

Williams-Beuren syndrome critical region-5/non-T-cell activation linker: a novel target gene of AML1/ETO.

1 reference

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21 January 2018

Epigenetic consequences of AML1-ETO action at the human c-FMS locus

1 reference

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21 January 2018

Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

1 reference

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21 January 2018

Bioconductor: open software development for computational biology and bioinformatics

1 reference

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21 January 2018

Global and Hox-specific roles for the MLL1 methyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

21 January 2018

AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

21 January 2018

Multiple regions of ETO cooperate in transcriptional repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

21 January 2018

Inhibition of the transforming growth factor beta 1 signaling pathway by the AML1/ETO leukemia-associated fusion protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

21 January 2018

Downregulation of the potential suppressor gene IGFBP-rP1 in human breast cancer is associated with inactivation of the retinoblastoma protein, cyclin E overexpression and increased proliferation in estrogen receptor negative tumors

1 reference

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21 January 2018

ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO

1 reference

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21 January 2018

Up-regulation of SLAP in FLI-1-transformed erythroblasts interferes with EpoR signaling

1 reference

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21 January 2018

AML-1, PU.1, and Sp3 regulate expression of human bactericidal/permeability-increasing protein

1 reference

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21 January 2018

The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

21 January 2018

Characterization of insulin-like growth factor-binding protein-related proteins (IGFBP-rPs) 1, 2, and 3 in human prostate epithelial cells: potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epithelium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

21 January 2018

ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

21 January 2018

The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

21 January 2018

The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein

1 reference

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21 January 2018

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

1 reference

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21 January 2018

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

1 reference

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21 January 2018

Chromosome translocations and covert leukemic clones are generated during normal fetal development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

21 January 2018

Structure and expression pattern of a human MTG8/ETO family gene, MTGR1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

21 January 2018

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

21 January 2018

AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

21 January 2018

Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells

1 reference

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21 January 2018

Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II

1 reference

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21 January 2018

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

1 reference

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21 January 2018

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

1 reference

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21 January 2018

The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF

1 reference

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21 January 2018

Src-like adaptor protein (Slap) is a negative regulator of mitogenesis

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21 January 2018

Gene expression profiling of pediatric acute myelogenous leukemia

1 reference

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21 January 2018

Establishment and characterization of a human histiocytic lymphoma cell line (U-937)

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Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid

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21 January 2018

The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells

1 reference

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21 January 2018

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

1 reference

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

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The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

1 reference

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Inhibition of insulin receptor activation by insulin-like growth factor binding proteins

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Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

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E protein silencing by the leukemogenic AML1-ETO fusion protein

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Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter

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The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

1 reference

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BAALC, a novel marker of human hematopoietic progenitor cells*1

1 reference

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7 January 2021

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Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma

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7 January 2021

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Transcriptional regulation by the t(8;21) fusion protein, AML-1/ETO.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209638

7 January 2021

based on heuristic

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Prognostically useful gene-expression profiles in acute myeloid leukemia.

1 reference

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7 January 2021

based on heuristic

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Bayesian forecasting improves the prediction of intraoperative plasma concentrations of alfentanil.

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Identification of a gene expression signature associated with pediatric AML prognosis

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10.1038/SJ.ONC.1209638

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20 January 2020

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Europe PubMed Central

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20 January 2020

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