(Q38315883)

2 September 2017

1 reference

title

Multifaceted role of the ubiquitin ligase Itch in immune regulation (English)

1 reference

2 September 2017

K Venuprasad

1

1 reference

2 September 2017

Minghui Zeng

series ordinal

2

1 reference

2 September 2017

Scott L Baughan

series ordinal

3

1 reference

2 September 2017

Ramin Massoumi

series ordinal

4

1 reference

2 September 2017

publication date

13 January 2015

1 reference

Immunology & Cell Biology

2 September 2017

published in

1 reference

2 September 2017

volume

93

1 reference

2 September 2017

issue

5

1 reference

2 September 2017

page(s)

452-460

1 reference

https://scigraph.springernature.com/pub.10.1038/icb.2014.118

2 September 2017

exact match

0 references

cites work

Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Ubiquitin ligases and the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Mechanisms underlying ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Physiological functions of the HECT family of ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Cbl and Itch binding sites in ERBB4 CYT-1 and CYT-2 mediate K48- and K63-polyubiquitination, respectively

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Human ITCH is a coregulator of the hematopoietic transcription factor NF-E2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The age of crosstalk: phosphorylation, ubiquitination, and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Plasticity of CD4+ T cell lineage differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Control of Th2-mediated inflammation by regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Clonal selection and learning in the antibody system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Structure and function of the B cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Itchy, a Nedd4 Ubiquitin Ligase, Downregulates Latent Membrane Protein 2A Activity in B-Cell Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Regulation of Epstein-Barr virus latency by latent membrane protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Epstein-Barr virus LMP2A-induced B-cell survival in two unique classes of EmuLMP2A transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: importance depends on the nature of the antigen-antibody interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Distinct intracellular compartments involved in invariant chain degradation and antigenic peptide loading of major histocompatibility complex (MHC) class II molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Seven-transmembrane receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

A novel CXC chemokine PBSF/SDF-1 and its receptor CXCR4: their functions in development, hematopoiesis and HIV infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Myocardial expression of CC- and CXC-chemokines and their receptors in human end-stage heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Involvement of chemokine receptors in breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Cancer and the chemokine network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Regulation of Smad activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

AIP4 restricts transforming growth factor-beta signaling through a ubiquitination-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

TGF-β induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

T cell anergy and costimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Transcriptional mechanisms underlying lymphocyte tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Behind the scenes of anergy: a tale of three E3s.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Shared principles in NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Ubiquitin chain cleavage: CYLD at work

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

Functional proteomics mapping of a human signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2014.118

CREB-2, a cellular CRE-dependent transcription repressor, functions in association with Tax as an activator of the human T-cell leukemia virus type 1 promoter

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25582340

12 December 2020

inferred from PubMed ID database lookup

Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25582340

12 December 2020

inferred from PubMed ID database lookup

Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein-Barr virus latency

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25582340

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/ICB.2014.118

1 reference

Dimensions Publication ID

2 September 2017

1030010940

0 references

Fatcat ID

release_lf3nfdzhnje7laoq36a3y3xti4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lf3nfdzhnje7laoq36a3y3xti4

24 November 2022

mapped directly with Wikidata item

1 reference