(Q38320607)

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Histone deacetylase inhibitor FK228 suppresses the Ras-MAP kinase signaling pathway by upregulating Rap1 and induces apoptosis in malignant melanoma

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scholarly article

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Europe PubMed Central

2 September 2017

Histone deacetylase inhibitor FK228 suppresses the Ras-MAP kinase signaling pathway by upregulating Rap1 and induces apoptosis in malignant melanoma (English)

1 reference

Europe PubMed Central

2 September 2017

apoptotic process

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author name string

Kobayashi Y

1

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Europe PubMed Central

2 September 2017

Ohtsuki M

2

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Europe PubMed Central

2 September 2017

Murakami T

3

1 reference

Europe PubMed Central

2 September 2017

Kobayashi T

4

1 reference

Europe PubMed Central

2 September 2017

Sutheesophon K

5

1 reference

Europe PubMed Central

2 September 2017

Kitayama H

6

1 reference

Europe PubMed Central

2 September 2017

Kano Y

7

1 reference

Europe PubMed Central

2 September 2017

Kusano E

8

1 reference

Europe PubMed Central

2 September 2017

Nakagawa H

9

1 reference

Europe PubMed Central

2 September 2017

Furukawa Y

10

1 reference

Europe PubMed Central

2 September 2017

language of work or name

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publication date

1 January 2006

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Europe PubMed Central

2 September 2017

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Europe PubMed Central

2 September 2017

25

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Europe PubMed Central

2 September 2017

4

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Europe PubMed Central

2 September 2017

512-524

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Europe PubMed Central

2 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209072

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Mitogenic and oncogenic properties of the small G protein Rap1b

1 reference

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Biology of the Rap proteins, members of the ras superfamily of GTP-binding proteins

1 reference

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Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

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Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

1 reference

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RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts

1 reference

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BRAF alterations are associated with complex mutational profiles in malignant melanoma

1 reference

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Mutations of the BRAF gene in human cancer

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Rap1, a small GTP-binding protein is upregulated during arrest of proliferation in human keratinocytes

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Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

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The prognostic importance of tumor mitotic rate confirmed in 1317 patients with primary cutaneous melanoma and long follow-up

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Apaf-1 is a mediator of E2F-1-induced apoptosis

1 reference

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Drug-resistance in human melanoma

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Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA).

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Gene silencing in cancer in association with promoter hypermethylation

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SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia

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Trichostatin A Induces Morphological Changes and Gelsolin Expression by Inhibiting Histone Deacetylase in Human Carcinoma Cell Lines

1 reference

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Coassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1

1 reference

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Oncogenic mutations in B-Raf: some losses yield gains.

1 reference

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Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice

1 reference

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Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

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B-RAF is a therapeutic target in melanoma

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Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses

1 reference

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7 January 2021

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Histone deacetylase in carcinogenesis and its inhibitors as anti-cancer agents

1 reference

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Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

1 reference

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Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations

1 reference

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7 January 2021

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A ras-related gene with transformation suppressor activity

1 reference

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Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209072

7 January 2021

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BRAF mutations are common somatic events in melanocytic nevi

1 reference

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Role of the histone deacetylase complex in acute promyelocytic leukaemia

1 reference

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Histone deacetylases and cancer: causes and therapies

1 reference

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Histone deacetylases as therapeutic targets in hematologic malignancies

1 reference

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FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

1 reference

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Structures and functions of the K rev-1 transformation suppressor gene and its relatives

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The small GTPase, Rap1, mediates CD31-induced integrin adhesion

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On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b

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P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228

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Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPase

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Histone deacetylase inhibitors: a new class of immunosuppressors targeting a novel signal pathway essential for CD154 expression

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Apoptosis and melanoma chemoresistance

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Histone deacetylase inhibitors--a new tool to treat cancer

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Involvement of the tumor necrosis factor (TNF)/TNF receptor system in leukemic cell apoptosis induced by histone deacetylase inhibitor depsipeptide (FK228).

1 reference

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Long-term proliferation of human melanocytes is supported by the physiologic mitogens alpha-melanotropin, endothelin-1, and basic fibroblast growth factor

1 reference

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Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion

1 reference

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FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity

1 reference

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cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

1 reference

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 reference

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DOCK4, a GTPase activator, is disrupted during tumorigenesis

1 reference

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Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1 reference

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Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis

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10.1038/SJ.ONC.1209072

1 reference

Europe PubMed Central

2 September 2017

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1 reference

Europe PubMed Central

2 September 2017

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