(Q38321332)

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SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.

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6 January 2020

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice (English)

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6 January 2020

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6 January 2020

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Haruhisa Iguchi

1

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6 January 2020

Yukio Ikeda

2

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6 January 2020

Masashi Okamura

3

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6 January 2020

Toshiya Tanaka

4

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6 January 2020

Yasuyo Urashima

5

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6 January 2020

Hiroto Ohguchi

6

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6 January 2020

Shinobu Takayasu

7

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6 January 2020

Noriaki Kojima

8

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6 January 2020

Satoshi Iwasaki

9

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6 January 2020

Riuko Ohashi

10

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6 January 2020

Shuying Jiang

11

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6 January 2020

Go Hasegawa

12

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6 January 2020

Ryoichi X Ioka

13

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6 January 2020

Kenta Magoori

14

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6 January 2020

Koichi Sumi

15

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6 January 2020

Takashi Maejima

16

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6 January 2020

Aoi Uchida

17

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6 January 2020

Makoto Naito

18

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Timothy F Osborne

19

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6 January 2020

Masashi Yanagisawa

20

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6 January 2020

Tokuo T Yamamoto

21

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6 January 2020

Tatsuhiko Kodama

22

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7 September 2005

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6 January 2020

Journal of Biological Chemistry

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6 January 2020

280

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37669-37680

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6 January 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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Type 2 diabetes-a matter of beta-cell life and death?

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beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats

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Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes

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Glucose regulation of gene transcription

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21 January 2018

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

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Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood

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21 January 2018

Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

1 reference

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21 January 2018

PDX:PBX complexes are required for normal proliferation of pancreatic cells during development

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Glucose stimulates the activation domain potential of the PDX-1 homeodomain transcription factor

1 reference

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21 January 2018

Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.

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The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic beta-cells

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21 January 2018

Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1.

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A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

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21 January 2018

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21 January 2018

Plat-E: an efficient and stable system for transient packaging of retroviruses

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21 January 2018

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

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21 January 2018

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10.1074/JBC.M505392200

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6 January 2020

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6 January 2020

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