(Q38327185)

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Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

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Europe PubMed Central

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2 September 2017

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

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Piotr J Balwierz

10

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Europe PubMed Central

PubMed publication ID

2 September 2017

Erik van Nimwegen

13

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Europe PubMed Central

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2 September 2017

object named as

Nicola Aceto

1

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Stefano Confalonieri

object named as

Stefano Confalonieri

7

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object named as

Guang Hu

9

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Mohamed Bentires-Alj

15

object named as

Mohamed Bentires-Alj

1 reference

Europe PubMed Central

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2 September 2017

author name string

Nina Sausgruber

2

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Europe PubMed Central

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2 September 2017

Heike Brinkhaus

3

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Europe PubMed Central

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2 September 2017

Dimos Gaidatzis

4

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Europe PubMed Central

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2 September 2017

Georg Martiny-Baron

5

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Europe PubMed Central

PubMed publication ID

2 September 2017

Giovanni Mazzarol

6

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Europe PubMed Central

PubMed publication ID

2 September 2017

Micaela Quarto

8

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Europe PubMed Central

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2 September 2017

Mikhail Pachkov

11

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Europe PubMed Central

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2 September 2017

Stephen J Elledge

12

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2 September 2017

Michael B Stadler

14

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2 September 2017

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publication date

4 March 2012

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2 September 2017

Nature Medicine

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2 September 2017

18

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2 September 2017

4

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2 September 2017

529-537

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Europe PubMed Central

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2 September 2017

https://scigraph.springernature.com/pub.10.1038/nm.2645

0 references

Metastasis: from dissemination to organ-specific colonization

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Stem cells in normal breast development and breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Prospective identification of tumorigenic breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Kinome signaling through regulated protein-protein interactions in normal and cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Cancer genes and the pathways they control

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Tyrosine phosphorylation: thirty years and counting

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

The tyrosine phosphatase Shp2 (PTPN11) in cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Protein-tyrosine phosphatases and cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

The tyrosine phosphatase Shp2 in development and cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

A role for the scaffolding adapter GAB2 in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Focal amplification and oncogene dependency of GAB2 in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Selective blockade of microRNA processing by Lin28

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

The let-7 family of microRNAs

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

The organizing principle: microenvironmental influences in the normal and malignant breast

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

The increasing complexity of the cancer stem cell paradigm

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Gene expression abnormalities in histologically normal breast epithelium of breast cancer patients.

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Transcriptome analysis of the normal human mammary cell commitment and differentiation process

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Genes that mediate breast cancer metastasis to the brain

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Progression-specific genes identified by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysis

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Generation of a functional mammary gland from a single stem cell

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

The Tyrosine Phosphatase Shp2 Interacts with NPM-ALK and Regulates Anaplastic Lymphoma Cell Growth and Migration

1 reference

https://api.crossref.org/works/10.1038%2FNM.2645

21 January 2018

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22388088

12 December 2020

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10.1038/NM.2645

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

ResearchGate publication ID

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