(Q38337743)

2 September 2017

title

The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity (English)

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2 September 2017

Alexey Dementiev

1

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2 September 2017

Maurice Petitou

series ordinal

2

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2 September 2017

Jean-Marc Herbert

series ordinal

3

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2 September 2017

Peter G W Gettins

series ordinal

4

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2 September 2017

publication date

15 August 2004

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Nature Structural & Molecular Biology

2 September 2017

published in

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2 September 2017

volume

11

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2 September 2017

issue

9

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2 September 2017

page(s)

863-867

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https://scigraph.springernature.com/pub.10.1038/nsmb810

2 September 2017

exact match

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cites work

Clinical use of low molecular weight heparins and heparinoids

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Serpin structure, mechanism, and function

21 January 2018

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Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.

21 January 2018

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Mechanism of heparin activation of antithrombin: evidence for an induced-fit model of allosteric activation involving two interaction subsites

21 January 2018

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Mechanism of heparin activation of antithrombin. Evidence for reactive center loop preinsertion with expulsion upon heparin binding

21 January 2018

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Synthesis of thrombin-inhibiting heparin mimetics without side effects

21 January 2018

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The anticoagulant activation of antithrombin by heparin

21 January 2018

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Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

21 January 2018

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The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site

21 January 2018

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The structure of a Michaelis serpin-protease complex

21 January 2018

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Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases

21 January 2018

1 reference

Role of Leu99 of thrombin in determining the P2 specificity of serpins

21 January 2018

1 reference

Importance of the P2 glycine of antithrombin in target proteinase specificity, heparin activation, and the efficiency of proteinase trapping as revealed by a P2 Gly --> Pro mutation.

21 January 2018

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Biological implications of a 3 A structure of dimeric antithrombin

21 January 2018

1 reference

Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin

21 January 2018

1 reference

The conformational activation of antithrombin. A 2.85-A structure of a fluorescein derivative reveals an electrostatic link between the hinge and heparin binding regions

21 January 2018

1 reference

The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions

21 January 2018

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The structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence Chemical and13C nuclear-magnetic-resonance studies

21 January 2018

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The molecular-weight-dependence of the anti-coagulant activity of heparin

21 January 2018

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Molecular mapping of the heparin-binding exosite of thrombin

21 January 2018

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Reactivities of the S2 and S3 subsite residues of thrombin with the native and heparin-induced conformers of antithrombin

21 January 2018

1 reference

Tryptophan 60-D in the B-insertion loop of thrombin modulates the thrombin-antithrombin reaction

21 January 2018

1 reference

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

21 January 2018

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Role of arginine 132 and lysine 133 in heparin binding to and activation of antithrombin

21 January 2018

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A novel one-step purification of human α-thrombin after direct activation of crude prothrombin enriched from plasma

21 January 2018

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[26] Screening for heavy-atom derivatives and obtaining accurate isomorphous differences.

21 January 2018

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

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Rational design of synthetic heparin analogues with tailor-made coagulation factor inhibitory activity

21 January 2018

1 reference

Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity

31 March 2020

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Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.

31 March 2020

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Contribution of lysine 60f to S1' specificity of thrombin

31 March 2020

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The role of Glu(192) in the allosteric control of the S(2)' and S(3)' subsites of thrombin

31 March 2020

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Influence of Arginines 93, 97, and 101 of thrombin to its functional specificity

31 March 2020

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Preparation and characterization of anhydrothrombin

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB810

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2 September 2017

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