(Q38349096)

2 September 2017

Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression (English)

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2 September 2017

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Z L Wu

1

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2 September 2017

S S Zheng

2

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2 September 2017

Z M Li

3

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2 September 2017

Y Y Qiao

4

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2 September 2017

M Y Aau

5

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2 September 2017

Q Yu

6

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2 September 2017

6 November 2009

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Cell Death & Differentiation

2 September 2017

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2 September 2017

17

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2 September 2017

801-810

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2 September 2017

5

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https://scigraph.springernature.com/pub.10.1038/cdd.2009.162

2 September 2017

0 references

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E2F - at the crossroads of life and death

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p14ARF links the tumour suppressors RB and p53.

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Role for the p53 homologue p73 in E2F-1-induced apoptosis

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Role of the p53-homologue p73 in E2F1-induced apoptosis

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Apaf-1 is a transcriptional target for E2F and p53

21 January 2018

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Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

21 January 2018

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Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim.

21 January 2018

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An E2F1-dependent gene expression program that determines the balance between proliferation and cell death

21 January 2018

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Specificity in the activation and control of transcription factor E2F-dependent apoptosis

21 January 2018

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Apoptotic and growth-promoting activity of E2F modulated by MDM2

21 January 2018

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E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines

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Inactivation of the p53 pathway in retinoblastoma.

21 January 2018

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Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents

21 January 2018

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Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

21 January 2018

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Epigenetics provides a new generation of oncogenes and tumour-suppressor genes

21 January 2018

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An elaborate pathway required for Ras-mediated epigenetic silencing

21 January 2018

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c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1

21 January 2018

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The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2009.162

The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

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Repression of E-cadherin by the polycomb group protein EZH2 in cancer

21 January 2018

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Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation

21 January 2018

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CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells

21 January 2018

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DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications

21 January 2018

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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

21 January 2018

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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

21 January 2018

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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

21 January 2018

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Direct coupling of the cell cycle and cell death machinery by E2F.

21 January 2018

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E2F target genes: unraveling the biology

21 January 2018

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E2F1 death pathways as targets for cancer therapy

21 January 2018

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Cellular mechanisms of tumour suppression by the retinoblastoma gene.

21 January 2018

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Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells

21 January 2018

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Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells

21 January 2018

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CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

21 January 2018

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Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

21 January 2018

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

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MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2009.162

Bim is a suppressor of Myc-induced mouse B cell leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2009.162

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.162

siRNA-mediated gene silencing: a global genome view

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.162

Apoptosis signal-regulating kinase 1 is a direct target of E2F1 and contributes to histone deacetylase inhibitor-induced apoptosis through positive feedback regulation of E2F1 apoptotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.162

An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2009.162

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/CDD.2009.162

1 reference

2 September 2017

1 reference