(Q38354327)

2 September 2017

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title

Monoamine oxidase: radiotracer chemistry and human studies (English)

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2 September 2017

2

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2 September 2017

1

Joanna S Fowler

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2 September 2017

6

Nora D Volkow

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2 September 2017

5

Gene-Jack Wang

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2 September 2017

4

Nelly Alia-Klein

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2 September 2017

3

Elena Shumay

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2 September 2017

publication date

10 February 2015

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Journal of Labelled Compounds and Radiopharmaceuticals

2 September 2017

published in

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2 September 2017

volume

58

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2 September 2017

issue

3

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2 September 2017

page(s)

51-64

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Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: Focus on modulation of CNS monoamine neurotransmitter release

2 September 2017

cites work

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Hydrogen peroxide produced by mitochondrial monoamine oxidase catalysis: biological implications

21 January 2018

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Monoamine oxidase in neuropsychiatry and behavior

21 January 2018

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Current place of monoamine oxidase inhibitors in the treatment of depression

21 January 2018

1 reference

Selective inhibitors of monoamine oxidase type B and the "cheese effect".

21 January 2018

1 reference

Monoamine oxidase: radiotracer development and human studies

21 January 2018

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Translational neuroimaging: positron emission tomography studies of monoamine oxidase.

21 January 2018

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Radiochemistry devoted to the production of monoamine oxidase (MAO-A and MAO-B) ligands for brain imaging with positron emission tomography

21 January 2018

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Species differences in [11C]clorgyline binding in brain

21 January 2018

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Selective, irreversible in vivo binding of [11C]clorgyline and [11C]-L-deprenyl in mice: potential for measurement of functional monoamine oxidase activity in brain using positron emission tomography

21 January 2018

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Synthesis of some 11C-labelled MAO-A inhibitors and their in vivo uptake kinetics in rhesus monkey brain

21 January 2018

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Non-MAO A binding of clorgyline in white matter in human brain

21 January 2018

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Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgyline

21 January 2018

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Monoamine oxidase A imaging in peripheral organs in healthy human subjects

21 January 2018

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Evidence that L-deprenyl treatment for one week does not inhibit MAO A or the dopamine transporter in the human brain

21 January 2018

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Graphical analysis of PET data applied to reversible and irreversible tracers

21 January 2018

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Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studies

21 January 2018

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Radioactive N,N-dimethylphenylethylamine: a selective radiotracer for in vivo measurement of monoamine oxidase-B activity in the brain

21 January 2018

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11C-labelling of dimethylphenethylamine in two different positions and biodistribution studies

21 January 2018

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11C-harmine as a tracer for monoamine oxidase A (MAO-A): in vitro and in vivo studies

21 January 2018

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MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography

21 January 2018

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Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain

21 January 2018

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Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [(11)C]-harmine positron emission tomography study

21 January 2018

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Mapping the cerebral monoamine oxidase type A: positron emission tomography characterization of the reversible selective inhibitor [11C]befloxatone

21 January 2018

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Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors

21 January 2018

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Synthesis and cerebral uptake of 1-(1-[(11)C]methyl-1H-pyrrol-2-yl)-2-phenyl-2-(1-pyrrolidinyl)ethanone, a novel tracer for positron emission tomography studies of monoamine oxidase type A.

21 January 2018

1 reference

[(11)C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: preclinical characterisation in nonhuman primate

21 January 2018

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Kinetic modeling of the monoamine oxidase B radioligand [¹¹C]SL25.1188 in human brain with high-resolution positron emission tomography

21 January 2018

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[11C]befloxatone distribution is well correlated to monoamine oxidase A protein levels in the human brain

21 January 2018

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Synthesis of (R)-(-)- and (S)-(+)-4-fluorodeprenyl and (R)-(-)- and (S)-(+)-[N-11C-methyl]-4-fluorodeprenyl and positron emission tomography studies in baboon brain

21 January 2018

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The synthesis of no-carrier-added DL-4-[18F]fluorodeprenyl via the nucleophilic aromatic substitution reaction

21 January 2018

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N-(6-18F-fluorohexyl)-N-methylpropargylamine: a fluorine-18-labeled monoamine oxidase B inhibitor for potential use in PET studies

21 January 2018

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Development of new radiopharmaceuticals for imaging monoamine oxidase B.

21 January 2018

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Synthesis of three novel fluorine-18 labeled analogues of L-deprenyl for positron emission tomography (PET) studies of monoamine oxidase B (MAO-B).

21 January 2018

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Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B).

21 January 2018

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Development of a novel fluorine-18 labeled deuterated fluororasagiline ([(18)F]fluororasagiline-D2) radioligand for PET studies of monoamino oxidase B (MAO-B).

21 January 2018

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Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity

21 January 2018

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Synthesis of fluorine and iodine analogues of clorgyline and selective inhibition of monoamine oxidase A.

21 January 2018

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Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A

21 January 2018

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Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinical phenotypes

21 January 2018

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A functional polymorphism in the monoamine oxidase A gene promoter

21 January 2018

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Role of genotype in the cycle of violence in maltreated children

21 January 2018

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Neurobiological mechanisms for impulsive-aggression: the role of MAOA.

21 January 2018

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Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects

21 January 2018

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Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men.

21 January 2018

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GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease

21 January 2018

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Brain monoamine oxidase A activity predicts trait aggression

21 January 2018

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Relationship of monoamine oxidase A binding to adaptive and maladaptive personality traits

21 January 2018

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Monoamine oxidase and cigarette smoking.

21 January 2018

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Brain monoamine oxidase A inhibition in cigarette smokers

21 January 2018

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Inhibition of monoamine oxidase B in the brains of smokers

21 January 2018

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An acute dose of nicotine does not inhibit MAO B in baboon brain in vivo

21 January 2018

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Cerebral monoamine oxidase A inhibition in tobacco smokers confirmed with PET and [11C]befloxatone

21 January 2018

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Low monoamine oxidase B in peripheral organs in smokers

21 January 2018

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Monoamine oxidase A binding in the prefrontal and anterior cingulate cortices during acute withdrawal from heavy cigarette smoking

21 January 2018

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Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression

21 January 2018

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Greater monoamine oxidase a binding in alcohol dependence

21 January 2018

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21 January 2018

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PET with 11C-deuterium-deprenyl and 18F-FDG in focal epilepsy.

21 January 2018

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Comparison of Brain Glucose Metabolism and Monoamine Oxidase B (MAO B) in Traumatic Brain Injury

21 January 2018

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Evidence for astrocytosis in ALS demonstrated by [11C](L)-deprenyl-D2 PET.

21 January 2018

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Multitracer study with positron emission tomography in Creutzfeldt-Jakob disease

21 January 2018

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Activated MAO-B in the brain of Alzheimer patients, demonstrated by [11C]-L-deprenyl using whole hemisphere autoradiography.

21 January 2018

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Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG.

21 January 2018

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In vivo molecular imaging biomarkers: clinical pharmacology's new "PET"?

21 January 2018

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Monoamine oxidase A and B substrates: probing the pathway for drug development

21 January 2018

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Monoamine oxidase B (MAO B) inhibitor therapy in Parkinson's disease: the degree and reversibility of human brain MAO B inhibition by Ro 19 6327.

21 January 2018

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Turnover of brain monoamine oxidase measured in vivo by positron emission tomography using L-[11C]deprenyl

21 January 2018

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Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography

21 January 2018

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Assessment of MAO-B occupancy in the brain with PET and [11C]-L-deprenyl-D2: a dose-finding study with a novel MAO-B inhibitor, EVT 301.

21 January 2018

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Monoamine oxidase A inhibitor occupancy during treatment of major depressive episodes with moclobemide or St. John's wort: an [11C]-harmine PET study

21 January 2018

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Reversible inhibitors of monoamine oxidase-A (RIMAs): robust, reversible inhibition of human brain MAO-A by CX157.

21 January 2018

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Drug delivery in the twenty-first century: a new paradigm

21 January 2018

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Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis

21 January 2018

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Monoamine oxidase B activity is increased in human gliomas.

21 January 2018

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Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans

21 January 2018

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New insights into the structures and functions of human monoamine oxidases A and B

21 January 2018

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Measurement of human cerebral monoamine oxidase type B (MAO-B) activity with positron emission tomography (PET): a dose ranging study with the reversible inhibitor Ro 19-6327

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JLCR.3247

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2 September 2017

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