(Q38359673)

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Identification of lysine-411 in the human reduced folate carrier as an important determinant of substrate selectivity and carrier function by systematic site-directed mutagenesis

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Europe PubMed Central

2 September 2017

Identification of lysine-411 in the human reduced folate carrier as an important determinant of substrate selectivity and carrier function by systematic site-directed mutagenesis (English)

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Europe PubMed Central

2 September 2017

1 reference

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author name string

Teah L Witt

1

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Europe PubMed Central

2 September 2017

Larry H Matherly

2

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Europe PubMed Central

2 September 2017

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publication date

1 December 2002

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Europe PubMed Central

2 September 2017

Biochimica et Biophysica Acta

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Europe PubMed Central

2 September 2017

1567

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Europe PubMed Central

2 September 2017

1-2

1 reference

Europe PubMed Central

2 September 2017

56-62

1 reference

Europe PubMed Central

2 September 2017

The cellular pharmacology of methotrexate

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2802%2900583-7

7 January 2021

based on heuristic

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Molecular and cellular biology of the human reduced folate carrier

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2802%2900583-7

7 January 2021

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A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2802%2900583-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A single amino acid difference within the folate transporter encoded by the murine RFC-1 gene selectively alters its interaction with folate analogues. Implications for intrinsic antifolate resistance and directional orientation of the transporter w

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2802%2900583-7

7 January 2021

based on heuristic

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Human K562 transfectants expressing high levels of reduced folate carrier but exhibiting low transport activity

1 reference

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7 January 2021

based on heuristic

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Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2802%2900583-7

7 January 2021

based on heuristic

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A reduced folate carrier mutation produces substrate-dependent alterations in carrier mobility in murine leukemia cells and methotrexate resistance with conservation of growth in 5-formyltetrahydrofolate

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2802%2900583-7

7 January 2021

based on heuristic

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A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2802%2900583-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate

1 reference

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7 January 2021

based on heuristic

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Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2802%2900583-7

7 January 2021

based on heuristic

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Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2802%2900583-7

7 January 2021

based on heuristic

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

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based on heuristic

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Topological and functional analysis of the human reduced folate carrier by hemagglutinin epitope insertion

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2802%2900583-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of membrane topology of the human reduced folate carrier protein by hemagglutinin epitope insertion and scanning glycosylation insertion mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2802%2900583-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The characteristics of the membrane transport of amethopterin and the naturally occurring folates

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction between anions and the reduced folate/methotrexate transport system in L1210 cell plasma membrane vesicles: directional symmetry and anion specificity for differential mobility of loaded and unloaded carrier

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2736%2802%2900583-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0005-2736(02)00583-7

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1 reference

Europe PubMed Central

2 September 2017

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