(Q38364160)

2 September 2017

title

Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site (English)

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2 September 2017

7

Joann B Sweasy

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2 September 2017

5

Kristin A Eckert

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2 September 2017

Mausumi Maitra

1

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2 September 2017

Andrew Gudzelak

2

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2 September 2017

Shu-Xia Li

3

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2 September 2017

Yoshihiro Matsumoto

4

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2 September 2017

Joachim Jager

6

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2 September 2017

language of work or name

English

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publication date

16 July 2002

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

277

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2 September 2017

issue

38

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2 September 2017

page(s)

35550-35560

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Enzymic release of 5'-terminal deoxyribose phosphate residues from damaged DNA in human cells

2 September 2017

cites work

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Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

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Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis

21 January 2018

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Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity

21 January 2018

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A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase beta

21 January 2018

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Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism

21 January 2018

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Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism

21 January 2018

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Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

21 January 2018

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Requirement of mammalian DNA polymerase-beta in base-excision repair.

21 January 2018

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Evidence for a role for DNA polymerase beta in mammalian meiosis

21 January 2018

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The Tyr-265-to-Cys mutator mutant of DNA polymerase beta induces a mutator phenotype in mouse LN12 cells

21 January 2018

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Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

21 January 2018

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Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta

21 January 2018

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Increased activity and fidelity of DNA polymerase beta on single-nucleotide gapped DNA.

21 January 2018

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The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA.

21 January 2018

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DNA polymerase beta in abasic site repair: a structurally conserved helix-hairpin-helix motif in lesion detection by base excision repair enzymes

21 January 2018

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Structural design of a eukaryotic DNA repair polymerase: DNA polymerase beta.

21 January 2018

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Detection and characterization of mammalian DNA polymerase beta mutants by functional complementation in Escherichia coli

21 January 2018

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A genetic system to identify DNA polymerase beta mutator mutants

21 January 2018

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recA-dependent and recA-independent N-ethyl-N-nitrosourea mutagenesis at a plasmid-encoded herpes simplex virus thymidine kinase gene in Escherichia coli

21 January 2018

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Analyzing fidelity of DNA polymerases.

21 January 2018

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3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection

21 January 2018

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Rapid quench kinetic analysis of polymerases, adenosinetriphosphatases, and enzyme intermediates

21 January 2018

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Development and use of an in vitro HSV-tk forward mutation assay to study eukaryotic DNA polymerase processing of DNA alkyl lesions

21 January 2018

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The E249K mutator mutant of DNA polymerase beta extends mispaired termini

21 January 2018

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DNA polymerase beta: pre-steady-state kinetic analysis and roles of arginine-283 in catalysis and fidelity.

21 January 2018

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Characterization of DNA polymeraseβ mutants with amino acid substitutions located in the C-terminal portion of the enzyme

21 January 2018

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Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism

21 January 2018

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Involvement of phenylalanine 272 of DNA polymerase beta in discriminating between correct and incorrect deoxynucleoside triphosphates

21 January 2018

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Y265H mutator mutant of DNA polymerase beta. Proper teometric alignment is critical for fidelity

21 January 2018

1 reference

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The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors

21 January 2018

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Mammalian base excision repair and DNA polymerase beta

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M204953200

1 reference

2 September 2017

1 reference