(Q38365365)

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Scientific and Regulatory Policy Committee Points-to-consider Paper*: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part 2. Antisense Oligonucleotides

scientific article published on 24 February 2015

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Europe PubMed Central

PubMed publication ID

2 September 2017

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Europe PubMed Central

Scientific and Regulatory Policy Committee Points-to-consider Paper*: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part 2. Antisense Oligonucleotides (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

author name string

Jeffery A Engelhardt

1

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Europe PubMed Central

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2 September 2017

Pierluigi Fant

2

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Europe PubMed Central

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2 September 2017

Silvia Guionaud

3

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Europe PubMed Central

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2 September 2017

Scott P Henry

4

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Europe PubMed Central

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2 September 2017

Michael W Leach

5

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Europe PubMed Central

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2 September 2017

Calvert Louden

6

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Europe PubMed Central

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2 September 2017

Marshall S Scicchitano

7

1 reference

Europe PubMed Central

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2 September 2017

James L Weaver

8

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Europe PubMed Central

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2 September 2017

Tanja S Zabka

9

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Europe PubMed Central

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2 September 2017

Kendall S Frazier

10

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Europe PubMed Central

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2 September 2017

Society of Toxicologic Pathology Vascular Injury Working Group

11

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2 September 2017

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publication date

24 February 2015

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2 September 2017

Toxicologic Pathology

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Europe PubMed Central

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2 September 2017

43

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Europe PubMed Central

PubMed publication ID

2 September 2017

7

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Europe PubMed Central

PubMed publication ID

2 September 2017

935-944

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Europe PubMed Central

PubMed publication ID

2 September 2017

Recent insights into C3 glomerulopathy

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Translation strategy for the qualification of drug-induced vascular injury biomarkers.

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Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys

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Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response

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Spontaneous lesions of the cardiovascular system in purpose-bred laboratory nonhuman primates.

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Newly identified CpG ODNs, M5-30 and M6-395, stimulate mouse immune cells to secrete TNF-alpha and enhance Th1-mediated immunity

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Transcriptional profiling of laser capture microdissected rat arterial elements: fenoldopam-induced vascular toxicity as a model system

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Potential candidate genomic biomarkers of drug induced vascular injury in the rat.

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Where disease pathogenesis meets protein formulation: renal deposition of immunoglobulin aggregates.

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Spontaneous and drug-induced hepatic pathology of the laboratory beagle dog, the cynomolgus macaque and the marmoset

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21 January 2018

Scientific and Regulatory Policy Committee Points-to-consider Paper*: Drug-induced Vascular Injury Associated with Nonsmall Molecule Therapeutics in Preclinical Development: Part I. Biotherapeutics

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21 January 2018

Species-specific inflammatory responses as a primary component for the development of glomerular lesions in mice and monkeys following chronic administration of a second-generation antisense oligonucleotide.

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Crosstalk pathways between Toll-like receptors and the complement system

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21 January 2018

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

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21 January 2018

Inhibition of coagulation by a phosphorothioate oligonucleotide.

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21 January 2018

Correlation of toxicity and pharmacokinetic properties of a phosphorothioate oligonucleotide designed to inhibit ICAM-1.

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21 January 2018

Drug-induced vascular injury--a quest for biomarkers.

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21 January 2018

Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides

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21 January 2018

CpG motifs in bacterial DNA and their immune effects

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21 January 2018

Biomarkers and mechanisms of drug-induced vascular injury in non-rodents

1 reference

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21 January 2018

International harmonization of toxicologic pathology nomenclature: an overview and review of basic principles

1 reference

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21 January 2018

The origin of cynomolgus monkey affects the outcome of kidney allografts under Neoral immunosuppression

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21 January 2018

Plasmodium coatneyi: differential clinical and immune responses of two populations of Macaca fascicularis from different origins

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21 January 2018

Nonclinical safety biomarkers of drug-induced vascular injury: current status and blueprint for the future

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21 January 2018

Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis

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21 January 2018

Evaluation of the renal effects of an antisense phosphorothioate oligodeoxynucleotide in monkeys

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21 January 2018

Synthetic oligonucleotides: the development of antisense therapeutics

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21 January 2018

Immunogenicity of biologically-derived therapeutics: assessment and interpretation of nonclinical safety studies

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21 January 2018

CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia.

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21 January 2018

Stimulation of the immune system by therapeutic antisense oligodeoxynucleotides and small interfering RNAs via nucleic acid receptors

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21 January 2018

Formation, clearance, deposition, pathogenicity, and identification of biopharmaceutical-related immune complexes: review and case studies

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21 January 2018

Histopathology of incidental findings in cynomolgus monkeys ( macaca fascicularis ) used in toxicity studies

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21 January 2018

Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans

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21 January 2018

Non-CpG-containing antisense 2'-methoxyethyl oligonucleotides activate a proinflammatory response independent of Toll-like receptor 9 or myeloid differentiation factor 88.

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21 January 2018

Pathways for cytokine secretion.

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21 January 2018

Blood cytokines as biomarkers of in vivo toxicity in preclinical safety assessment: considerations for their use.

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Spontaneous findings in the heart of Mauritian-origin cynomolgus macaques (Macaca fascicularis).

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21 January 2018

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10.1177/0192623315570341

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

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