(Q38383263)

2 September 2017

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title

A Review: Phytochemicals Targeting JAK/STAT Signaling and IDO Expression in Cancer (English)

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2 September 2017

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Niroshaathevi Arumuggam

series ordinal

1

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2 September 2017

Neil A Bhowmick

series ordinal

2

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2 September 2017

H P Vasantha Rupasinghe

series ordinal

3

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2 September 2017

publication date

18 March 2015

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2 September 2017

published in

Phytotherapy Research

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2 September 2017

volume

29

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2 September 2017

issue

6

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2 September 2017

page(s)

805-817

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Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells

2 September 2017

cites work

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Candidate mechanisms for chemotherapy-induced cognitive changes

21 January 2018

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Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.

21 January 2018

1 reference

A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase

21 January 2018

1 reference

Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells.

21 January 2018

1 reference

Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

21 January 2018

1 reference

Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation

21 January 2018

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Involvement of a JAK/STAT pathway inhibitor: cytokine inducible SH2 containing protein in breast cancer

21 January 2018

1 reference

21 January 2018

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Stat proteins and oncogenesis

21 January 2018

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21 January 2018

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Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.

21 January 2018

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Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562.

21 January 2018

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Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.

21 January 2018

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Cucurbitacins and cucurbitane glycosides: structures and biological activities

21 January 2018

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Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells

21 January 2018

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Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases.

21 January 2018

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Indoleamine 2,3-dioxygenase, an immunomodulatory protein, is suppressed by (-)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cells

21 January 2018

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Plasmacytoid dendritic cells in immunity

21 January 2018

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STATs and gene regulation

21 January 2018

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

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Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase.

21 January 2018

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Lipopolysaccharide induction of indoleamine 2,3-dioxygenase is mediated dominantly by an IFN-gamma-independent mechanism

21 January 2018

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Critical role of indoleamine 2,3-dioxygenase in tumor resistance to repeated treatments with targeted IFNgamma

21 January 2018

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Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer

21 January 2018

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Inhibition of STAT3 signaling targets both tumor-initiating and differentiated cell populations in prostate cancer

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Hallmarks of Cancer: The Next Generation

21 January 2018

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Overview of genotoxic carcinogens and non-genotoxic carcinogens

21 January 2018

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Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling

21 January 2018

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Tumor heterogeneity: biological implications and therapeutic consequences

21 January 2018

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Methylome analysis reveals Jak-STAT pathway deregulation in putative breast cancer stem cells.

21 January 2018

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STAT proteins and transcriptional responses to extracellular signals

21 January 2018

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An interleukin-4-induced transcription factor: IL-4 Stat

21 January 2018

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Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo.

21 January 2018

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Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

21 January 2018

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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

21 January 2018

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(-)-Epigallocatechin gallate suppresses indoleamine 2,3-dioxygenase expression in murine dendritic cells: evidences for the COX-2 and STAT1 as potential targets.

21 January 2018

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Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase Cdelta-STAT1 signaling pathway in interferon-gamma-stimulated murine dendritic cells

21 January 2018

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Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells

21 January 2018

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Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.

21 January 2018

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Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue

21 January 2018

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Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia

21 January 2018

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Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein

21 January 2018

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JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells

21 January 2018

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Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases

21 January 2018

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Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy

21 January 2018

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Rosmarinic acid inhibits indoleamine 2,3-dioxygenase expression in murine dendritic cells

21 January 2018

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Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

21 January 2018

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Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis

21 January 2018

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Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells.

21 January 2018

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Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway

21 January 2018

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The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling.

21 January 2018

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Nature and nurture - lessons from chemical carcinogenesis

21 January 2018

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Resveratrol analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) mediates anti-tumor effects via mechanism different from that of resveratrol

21 January 2018

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Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice

21 January 2018

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Regulation of apoptosis by resveratrol through JAK/STAT and mitochondria mediated pathway in human epidermoid carcinoma A431 cells

21 January 2018

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Diet, nutrients, phytochemicals, and cancer metastasis suppressor genes

21 January 2018

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Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.

21 January 2018

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Prevention of allogeneic fetal rejection by tryptophan catabolism

21 January 2018

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IDO and tolerance to tumors

21 January 2018

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Indoleamine 2,3-dioxygenase and tumor-induced tolerance

21 January 2018

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Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

21 January 2018

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STAT3 inhibition of gluconeogenesis is downregulated by SirT1

21 January 2018

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Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase

21 January 2018

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Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

21 January 2018

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The role of indoleamine 2,3 dioxygenase in the induction of immune tolerance in organ transplantation

21 January 2018

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The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells.

21 January 2018

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The natural history of carcinogenesis: implications of experimental carcinogenesis in the genesis of human cancer

21 January 2018

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Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite

21 January 2018

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Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine

21 January 2018

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Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia

21 January 2018

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Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells

21 January 2018

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γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent

21 January 2018

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The JAK/STAT signaling pathway

21 January 2018

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Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells

21 January 2018

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Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.

21 January 2018

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Ins and outs of dietary phytochemicals in cancer chemoprevention.

21 January 2018

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Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

21 January 2018

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Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials

21 January 2018

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Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice

21 January 2018

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Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes.

21 January 2018

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JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells.

21 January 2018

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EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells

21 January 2018

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Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells

21 January 2018

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Cancer treatment and survivorship statistics, 2012

21 January 2018

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JAK/STAT/SOCS-signaling pathway and colon and rectal cancer

21 January 2018

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JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment

21 January 2018

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Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

21 January 2018

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Cancer chemoprevention with dietary phytochemicals

21 January 2018

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Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer.

21 January 2018

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Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells.

21 January 2018

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EGCG enhances the therapeutic potential of gemcitabine and CP690550 by inhibiting STAT3 signaling pathway in human pancreatic cancer

21 January 2018

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Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells

21 January 2018

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Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.

21 January 2018

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Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

21 January 2018

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Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design

21 January 2018

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Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells

21 January 2018

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Epigenetic impact of dietary polyphenols in cancer chemoprevention: lifelong remodeling of our epigenomes.

21 January 2018

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Effects of various phytochemicals on indoleamine 2,3-dioxygenase 1 activity: galanal is a novel, competitive inhibitor of the enzyme

21 January 2018

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Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway

21 January 2018

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STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes

21 January 2018

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The myeloproliferative disorder associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PTR.5327

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2 September 2017

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