(Q38412707)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27400857%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

Lithium suppression of tau induces brain iron accumulation and neurodegeneration (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27400857%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

1

1 reference

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18 March 2020

Scott Ayton

2

1 reference

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18 March 2020

James A. Duce

5

1 reference

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18 March 2020

Stephen J Wood

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27400857%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Christos Pantelis

11

1 reference

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18 March 2020

Alison R. Yung

13

1 reference

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18 March 2020

David I Finkelstein

14

1 reference

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18 March 2020

Ashley I. Bush

15

1 reference

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18 March 2020

author name string

A T Appukuttan

3

1 reference

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18 March 2020

S Moon

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27400857%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

I Volitakis

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27400857%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

R Cherny

7

1 reference

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18 March 2020

M Greenough

9

1 reference

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18 March 2020

G Berger

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27400857%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

P McGorry

12

1 reference

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18 March 2020

language of work or name

English

0 references

publication date

12 July 2016

1 reference

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full work available at URL

18 March 2020

http://eprints.whiterose.ac.uk/104131

content deliverer

White Rose Research Online

0 references

1 reference

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18 March 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27400857%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

issue

3

1 reference

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18 March 2020

page(s)

396-406

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https://scigraph.springernature.com/pub.10.1038/mp.2016.96

18 March 2020

exact match

0 references

cites work

Molecular targets of lithium action

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A critical appraisal of lithium's efficacy and effectiveness: the last 60 years

21 January 2018

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GSK-3 in Neurodegenerative Diseases.

21 January 2018

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A case of Parkinsonism due to lithium intoxication: treatment with Pramipexole.

21 January 2018

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Cogwheel rigidity related to lithium maintenance

21 January 2018

1 reference

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Parkinsonism due to lithium carbonate poisoning

21 January 2018

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Permanent neurological deficits due to lithium toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Tardive Parkinsonism, orofacial dyskinesia and akathisia following brief exposure to lithium carbonate

21 January 2018

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https://api.crossref.org/works/10.1038%2FMP.2016.96

Reversible neuropsychiatric side effects of lithium with normal serum levels. A case report

21 January 2018

1 reference

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Parkinsonian symptoms with lithium, lithium-neuroleptic, and lithium-antidepressant treatment

21 January 2018

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Lithium Use in Older Adults is Associated with Increased Prescribing of Parkinson Medications

21 January 2018

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https://api.crossref.org/works/10.1038%2FMP.2016.96

NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy

21 January 2018

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Neuroprotective effects of low-dose lithium in individuals at ultra-high risk for psychosis. A longitudinal MRI/MRS study.

21 January 2018

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https://api.crossref.org/works/10.1038%2FMP.2016.96

Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features

21 January 2018

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https://api.crossref.org/works/10.1038%2FMP.2016.96

Early interventions for youths at high risk for bipolar disorder: a developmental approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Cortical phase changes in Alzheimer's disease at 7T MRI: a novel imaging marker

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium improves hippocampal neurogenesis, neuropathology and cognitive functions in APP mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium down-regulates tau in cultured cortical neurons: a possible mechanism of neuroprotection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Inhibition of glycogen synthase kinase-3beta downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Motor and cognitive deficits in aged tau knockout mice in two background strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

β-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Nigral iron elevation is an invariable feature of Parkinson's disease and is a sufficient cause of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Iron pigment in the brain of a man with tardive dyskinesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

T2 values in the human brain: comparison with quantitative assays of iron and ferritin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

MRI in tardive dyskinesia: shortened left caudate T2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Cerebral T2-weighted signal decrease during aging in the mouse lemur primate reflects iron accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Improved T2* assessment in liver iron overload by magnetic resonance imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Validation of quantitative susceptibility mapping with Perls' iron staining for subcortical gray matter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Is lithium in a class of its own? A brief profile of its clinical use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Effects of drugs acting alone and in combination on the motor activity of intact mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Interdisciplinary study of diazepam sedation for outpatient dentistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

KCC2-deficient mice show reduced sensitivity to diazepam, but normal alcohol-induced motor impairment, gaboxadol-induced sedation, and neurosteroid-induced hypnosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Cortical glutamatergic neurons mediate the motor sedative action of diazepam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

The role of brain dopamine in behavioral regulation and the actions of psychotropic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium attenuates Drug-induced Hyperactivity in Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Effect of Lithium on Brain Dopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

GSK-3-selective inhibitors derived from Tyrian purple indirubins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Stable iron isotope tracing reveals significant brain iron uptake in adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium neurotoxicity at normal therapeutic levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Ageing as a risk factor for lithium neurotoxicity at therapeutic serum levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

A delicate balance: Iron metabolism and diseases of the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Prophylactic lithium treatment and cognitive performance in patients with a long history of bipolar illness: no simple answers in complex disease-treatment interplay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Effects of lithium on cognitive performance: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Superoxide dismutase protects calcineurin from inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Redox control of calcineurin by targeting the binuclear Fe(2+)-Zn(2+) center at the enzyme active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Role of bioavailable iron in coal dust-induced activation of activator protein-1 and nuclear factor of activated T cells: difference between Pennsylvania and Utah coal dusts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Deferoxamine synergistically enhances iron-mediated AP-1 activation: a showcase of the interplay between extracellular-signal-regulated kinase and tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

GSK3 and Alzheimer's Disease: Facts and Fiction….

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

The Aβ-induced NFAT apoptotic pathway is also activated by GSK-3 inhibition: implications for Alzheimer therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

A feasibility and tolerability study of lithium in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium time-to-event trial in amyotrophic lateral sclerosis stops early for futility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Lithium lacks effect on survival in amyotrophic lateral sclerosis: a phase IIb randomised sequential trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Biometals and their therapeutic implications in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Mapping of iron deposition in conjunction with assessment of nerve fiber tract integrity in amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2016.96

Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study.

21 January 2018

1 reference

12 December 2020

Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.

1 reference

12 December 2020

Delayed neuroprotection against cerebral ischemia reperfusion injury: putative role of BDNF and GSK-3β.

1 reference

12 December 2020

Lithium salts in the treatment of psychotic excitement

1 reference

12 December 2020

Brain iron in the rat: extremely slow turnover in normal rats may explain long-lasting effects of early iron deficiency

1 reference

12 December 2020

Lithium-induced cortical atrophy and cognitive dysfunction

1 reference

12 December 2020

Immunochemical and biochemical characterization of tau proteins in normal and Alzheimer's disease brains with Alz 50 and Tau-1.

1 reference

12 December 2020

Adaptive changes in the rat dopaminergic transmission following repeated lithium administration

1 reference

12 December 2020

The influence of age on lithium efficacy and side-effects in out-patients.

1 reference

12 December 2020

Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging

1 reference

12 December 2020

Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial

1 reference

12 December 2020

Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.

1 reference

12 December 2020

A cross-sectional study of parkinsonism and tardive dyskinesia in lithium-treated affective disordered patients.

1 reference

12 December 2020

Lithium inhibits neurite growth and tau protein kinase I/glycogen synthase kinase-3beta-dependent phosphorylation of juvenile tau in cultured hippocampal neurons.

1 reference

12 December 2020

Disabling Parkinsonism following brief exposure to lithium carbonate in amyotrophic lateral sclerosis

1 reference

12 December 2020

Massive accumulation of modified tau and severe depletion of normal tau characterize the cerebral cortex and white matter of Alzheimer's disease. Demonstration using the hydrated autoclaving method

1 reference

12 December 2020

Lithium and parkinsonism

1 reference

12 December 2020

Incipient neurovulnerability and neuroprotection in early psychosis

1 reference

12 December 2020

Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study.

1 reference

12 December 2020

Identifiers

DOI

10.1038/MP.2016.96

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27400857%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

0 references

0 references

Dimensions Publication ID

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27400857%20AND%20SRC:MED&resulttype=core&format=json