(Q27642879)

English

GSK-3-selective inhibitors derived from Tyrian purple indirubins

scientific article

In more languages

edit

Statements

instance of

scholarly article

0 references

title

GSK-3-selective inhibitors derived from Tyrian purple indirubins (English)

0 references

author

Paul Greengard

series ordinal

16

0 references

Andrea Musacchio

series ordinal

13

0 references

Prokopios Magiatis

object named as

Prokopios Magiatis

series ordinal

3

0 references

Alexios-Leandros Skaltsounis

series ordinal

2

object named as

Alexios-Leandros Skaltsounis

0 references

Ali Hemmati-Brivanlou

series ordinal

9

object named as

Ali Brivanlou

0 references

Laurent Meijer

series ordinal

1

object named as

Laurent Meijer

0 references

author name string

Panagiotis Polychronopoulos

series ordinal

4

0 references

Marie Knockaert

series ordinal

5

0 references

Maryse Leost

series ordinal

6

0 references

Xiaozhou P Ryan

series ordinal

7

0 references

Claudia Alin Vonica

series ordinal

8

0 references

Rana Dajani

series ordinal

10

0 references

Claudia Crovace

series ordinal

11

0 references

Cataldo Tarricone

series ordinal

12

0 references

S Mark Roe

series ordinal

14

0 references

Laurence Pearl

series ordinal

15

0 references

publication date

December 2003

0 references

published in

Chemistry and Biology

0 references

volume

10

0 references

page(s)

1255-66

0 references

issue

12

0 references

cites work

Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Structure of GSK3beta reveals a primed phosphorylation mechanism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

GSK3beta signalling: casting a wide net in Alzheimer's disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

The GSK3 beta signaling cascade and neurodegenerative disease.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Identification of an indigo precursor from leaves of Isatis tinctoria (Woad).

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Recruitment of dioxin receptor to active transcription sites

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

GSK-3: tricks of the trade for a multi-tasking kinase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Glycogen synthase kinase 3: an emerging therapeutic target

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Structure and regulation of the CDK5-p25(nck5a) complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Siamois is required for formation of Spemann's organizer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Indirubin and meisoindigo in the treatment of chronic myelogenous leukemia in China

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Tau as a drug target in Alzheimer's disease.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Alzheimer's disease: targets for drug development

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Wnt signal transduction: kinase cogs in a nano-machine?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

The specificities of protein kinase inhibitors: an update

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Tyrian Purple: 6,6’-Dibromoindigo and Related Compounds

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

New aspects of Wnt signaling pathways in higher vertebrates

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Inhibitors of glycogen synthase kinase-3: future therapy for unmet medical needs?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Wnt signaling involvement in beta-amyloid-dependent neurodegeneration.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

The renaissance of GSK3

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Wnt signaling controls the phosphorylation status of beta-catenin.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

Oxidation of indole by cytochrome P450 enzymes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CHEMBIOL.2003.11.010

(Q27642879)

GSK-3-selective inhibitors derived from Tyrian purple indirubins

Statements

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)