(Q38413376)

2 September 2017

1 reference

title

Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications (English)

1 reference

2 September 2017

2

Shinya Yamanaka

1 reference

2 September 2017

Taketaro Sadahiro

1

1 reference

2 September 2017

Masaki Ieda

series ordinal

3

1 reference

2 September 2017

publication date

1 April 2015

1 reference

2 September 2017

1 reference

2 September 2017

volume

116

1 reference

2 September 2017

issue

8

1 reference

2 September 2017

page(s)

1378-1391

1 reference

Induction of human neuronal cells by defined transcription factors

2 September 2017

cites work

1 reference

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE10202

COCI

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Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

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Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution

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Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase

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Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming.

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11 October 2022

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Reprogramming of human fibroblasts toward a cardiac fate

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct reprogramming of human fibroblasts to functional and expandable hepatocytes.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family.

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11 October 2022

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Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

The tumorigenicity of human embryonic stem cells

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Steps toward safe cell therapy using induced pluripotent stem cells

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct conversion of adult skin fibroblasts to endothelial cells by defined factors.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Cardiogenesis and the complex biology of regenerative cardiovascular medicine

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Maturation, not initiation, is the major roadblock during reprogramming toward pluripotency from human fibroblasts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

NANOG-dependent function of TET1 and TET2 in establishment of pluripotency

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Reprogramming the injured heart

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct reprogramming of mouse fibroblasts into cardiac myocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct reprogramming of mouse fibroblasts to neural progenitors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

From nuclear transfer to nuclear reprogramming: the reversal of cell differentiation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Guidelines and techniques for the generation of induced pluripotent stem cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Small molecules enable highly efficient neuronal conversion of human fibroblasts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

The epithelial-mesenchymal transition factor SNAIL paradoxically enhances reprogramming

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Conversion of mouse and human fibroblasts into functional spinal motor neurons

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Heart repair by cardiac reprogramming

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Cardiac stem cell therapy and the promise of heart regeneration

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Reprogramming paces the heart

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Adult cardiac stem cells are multipotent and support myocardial regeneration

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct conversion of human fibroblasts to dopaminergic neurons

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

CellNet: network biology applied to stem cell engineering

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Induced pluripotent stem cells for post-myocardial infarction repair: remarkable opportunities and challenges.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Dissecting engineered cell types and enhancing cell fate conversion via CellNet

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Engineering adolescence: maturation of human pluripotent stem cell-derived cardiomyocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Functional integration of dopaminergic neurons directly converted from mouse fibroblasts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Generation of human-induced pluripotent stem cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

iPS cells produce viable mice through tetraploid complementation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Sema3a maintains normal heart rhythm through sympathetic innervation patterning

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct conversion of human fibroblasts to multilineage blood progenitors.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Inhibition of TGFβ signaling increases direct conversion of fibroblasts to induced cardiomyocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct conversion of fibroblasts to functional neurons by defined factors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Intracellular Ca2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Hippo pathway effector Yap promotes cardiac regeneration

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Adult mice generated from induced pluripotent stem cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Generation of induced neuronal cells by the single reprogramming factor ASCL1

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

The Registry of the International Society for Heart and Lung Transplantation: Twenty-eighth Adult Heart Transplant Report--2011.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Mammalian heart renewal by pre-existing cardiomyocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Critical factors for cardiac reprogramming

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Generation of mouse induced pluripotent stem cells without viral vectors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Heart repair by reprogramming non-myocytes with cardiac transcription factors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Cardiac gene activation analysis in mammalian non-myoblasic cells by Nkx2-5, Tbx5, Gata4 and Myocd

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Deterministic direct reprogramming of somatic cells to pluripotency

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

MicroRNA-mediated conversion of human fibroblasts to neurons.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Reprogramming of murine and human somatic cells using a single polycistronic vector

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Induced regeneration--the progress and promise of direct reprogramming for heart repair

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Induction of pluripotent stem cells from fibroblast cultures.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

A molecular roadmap of reprogramming somatic cells into iPS cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Accelerated direct reprogramming of fibroblasts into cardiomyocyte-like cells with the MyoD transactivation domain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Induction of human cardiomyocyte-like cells from fibroblasts by defined factors

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

MicroRNA induced cardiac reprogramming in vivo: evidence for mature cardiac myocytes and improved cardiac function.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

iPS cells can support full-term development of tetraploid blastocyst-complemented embryos

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

An early developmental transcription factor complex that is more stable on nucleosome core particles than on free DNA.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1161/CIRCRESAHA.116.305374

Identifiers

DOI

10.1161/CIRCRESAHA.116.305374

1 reference

2 September 2017

1 reference