(Q38418048)

2 September 2017

Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells (English)

1 reference

2 September 2017

9

1 reference

2 September 2017

Pedro M Quirós

3

0 references

Angel G. Martin

object named as

Angel G Martin

7

0 references

Javier A Menendez

object named as

Javier A Menendez

10

0 references

Begoña Martin-Castillo

8

object named as

Begoña Martin-Castillo

1 reference

2 September 2017

Alejandro Vazquez-Martin

1

1 reference

2 September 2017

Luciano Vellon

2

1 reference

2 September 2017

Sílvia Cufí

4

1 reference

2 September 2017

Eunate Ruiz de Galarreta

5

1 reference

2 September 2017

Cristina Oliveras-Ferraros

6

1 reference

2 September 2017

1 March 2012

1 reference

2 September 2017

16

1 reference

based on heuristic

inferred from page(s)

published in

Cell Cycle

1 reference

2 September 2017

11

1 reference

2 September 2017

5

1 reference

2 September 2017

974-989

1 reference

Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine

2 September 2017

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Induced pluripotent stem cells and senescence: learning the biology to improve the technology

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

p53: guardian of reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Strategies and new developments in the generation of patient-specific pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Why myc? An unexpected ingredient in the stem cell cocktail

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Emerging role of KLF4 in human gastrointestinal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Direct cell reprogramming is a stochastic process amenable to acceleration

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

The role of p53 in limiting somatic cell reprogramming.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

The Ink4/Arf locus is a barrier for iPS cell reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Senescence impairs successful reprogramming to pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Cellular senescence in cancer and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Senescence in tumours: evidence from mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Oncogene-induced senescence and its role in tumor suppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Guidelines and techniques for the generation of induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Induced pluripotency: history, mechanisms, and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Small RNA-mediated regulation of iPS cell generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Inducing iPSCs to escape the dish.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Tumor suppressors and cell metabolism: a recipe for cancer growth

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Energy metabolism in nuclear reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Energy metabolism in human pluripotent stem cells and their differentiated counterparts

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Sensing of energy and nutrients by AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

AMPK as a metabolic tumor suppressor: control of metabolism and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Adenosine monophosphate-activated protein kinase: a central regulator of metabolism with roles in diabetes, cancer, and viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin and energy metabolism in breast cancer: from insulin physiology to tumour-initiating stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin: taking away the candy for cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin and other biguanides in oncology: advancing the research agenda

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Repositioning chloroquine and metformin to eliminate cancer stem cell traits in pre-malignant lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Role of AMP-activated protein kinase in mechanism of metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

An energetic tale of AMPK-independent effects of metformin.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Stem cells in mammary development and carcinogenesis: implications for prevention and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Suppression of induced pluripotent stem cell generation by the p53-p21 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

p53 connects tumorigenesis and reprogramming to pluripotency

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Module map of stem cell genes guides creation of epithelial cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

AMPK: Evidence for an energy-sensing cytokinetic tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

p53 regulates mitochondrial respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

p53 and metabolism: Inside the TIGAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator)

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Cellular life span and the Warburg effect

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

MYC-induced cancer cell energy metabolism and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Rethinking the Warburg effect with Myc micromanaging glutamine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Integrated analysis of ATM mediated gene and protein expression impacting cellular metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Vitamin C enhances the generation of mouse and human induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin: multi-faceted protection against cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Stem cell pluripotency and transcription factor Oct4.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

OCT4 Expression Enhances Features of Cancer Stem Cells in a Mouse Model of Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Generation of tumor-initiating cells by exogenous delivery of OCT4 transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Lin28 promotes transformation and is associated with advanced human malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

The role of let-7 in cell differentiation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Opposing microRNA families regulate self-renewal in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin may antagonize Lin28 and/or Lin28B activity, thereby boosting let-7 levels and antagonizing cancer progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Embryonic stem cell microRNAs: defining factors in induced pluripotent (iPS) and cancer (CSC) stem cells?

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

The Lin28/let-7 axis regulates glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Stem cells: The promises and perils of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Generation of mouse induced pluripotent stem cells without viral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Generation of induced pluripotent stem cells using recombinant proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Generation of induced pluripotent stem cells in the absence of drug selection

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

Targeting breast cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.11.5.19450

21 January 2018

Identifiers

DOI

10.4161/CC.11.5.19450

1 reference

2 September 2017

1 reference