(Q38424758)

3 September 2017

1 reference

title

The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases (English)

1 reference

3 September 2017

0 references

2

Abul K Abbas

1 reference

3 September 2017

David Klatzmann

1

1 reference

3 September 2017

language of work or name

1 reference

17 April 2015

1 reference

Nature Reviews Immunology

3 September 2017

published in

1 reference

3 September 2017

volume

15

1 reference

3 September 2017

issue

5

1 reference

3 September 2017

page(s)

283-294

1 reference

tTregs, pTregs, and iTregs: similarities and differences

3 September 2017

cites work

1 reference

Primary immune deficiency disorders presenting as autoimmune diseases: IPEX and APECED.

21 January 2018

1 reference

Th17 and regulatory T cell balance in autoimmune and inflammatory diseases

21 January 2018

1 reference

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

21 January 2018

1 reference

Administration of CD4+CD25highCD127- regulatory T cells preserves β-cell function in type 1 diabetes in children

21 January 2018

1 reference

The biology of interleukin-2.

21 January 2018

1 reference

Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy

21 January 2018

1 reference

Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis

21 January 2018

1 reference

Interleukin-2 and regulatory T cells in graft-versus-host disease

21 January 2018

1 reference

Interleukin 2: the molecule and its function

21 January 2018

1 reference

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

21 January 2018

1 reference

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

21 January 2018

1 reference

IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development

21 January 2018

1 reference

A function for interleukin 2 in Foxp3-expressing regulatory T cells

21 January 2018

1 reference

Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells

21 January 2018

1 reference

Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus

21 January 2018

1 reference

Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.

21 January 2018

1 reference

Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells

21 January 2018

1 reference

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

21 January 2018

1 reference

Induced CD4+Foxp3+ regulatory T cells in immune tolerance

21 January 2018

1 reference

Interleukin 2 plays a central role in Th2 differentiation.

21 January 2018

1 reference

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression

21 January 2018

1 reference

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

21 January 2018

1 reference

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

21 January 2018

1 reference

Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation

21 January 2018

1 reference

Foxp3+ follicular regulatory T cells control the germinal center response.

21 January 2018

1 reference

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

21 January 2018

1 reference

Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells

21 January 2018

1 reference

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

21 January 2018

1 reference

Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells

21 January 2018

1 reference

Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.

21 January 2018

1 reference

Human γδ thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling.

21 January 2018

1 reference

A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells

21 January 2018

1 reference

Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells

21 January 2018

1 reference

Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor

21 January 2018

1 reference

CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets

21 January 2018

1 reference

Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues

21 January 2018

1 reference

The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity

21 January 2018

1 reference

Selective stimulation of T cell subsets with antibody-cytokine immune complexes.

21 January 2018

1 reference

The role of IL-2 in the activation and expansion of regulatory T-cells and the development of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation

21 January 2018

1 reference

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

21 January 2018

1 reference

IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells

21 January 2018

1 reference

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

21 January 2018

1 reference

Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia

21 January 2018

1 reference

Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease

21 January 2018

1 reference

Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

21 January 2018

1 reference

Structure and expression of a cloned cDNA for human interleukin-2.

21 January 2018

1 reference

Clearance rates and systemic effects of intravenously administered interleukin 2 (IL-2) containing preparations in human subjects

21 January 2018

1 reference

Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer

21 January 2018

1 reference

Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer

21 January 2018

1 reference

IL-2: the first effective immunotherapy for human cancer.

21 January 2018

1 reference

IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients

21 January 2018

1 reference

In vivo expansion of naive and activated CD4+CD25+FOXP3+ regulatory T cell populations in interleukin-2-treated HIV patients

21 January 2018

1 reference

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells

21 January 2018

1 reference

Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza

21 January 2018

1 reference

Cytokine dysregulation as a mechanism of graft versus host disease

21 January 2018

1 reference

CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis.

21 January 2018

1 reference

Restoration of peripheral immune homeostasis after rituximab in mixed cryoglobulinemia vasculitis.

21 January 2018

1 reference

Correlation of clinical and virologic responses to antiviral treatment and regulatory T cell evolution in patients with hepatitis C virus-induced mixed cryoglobulinemia vasculitis

21 January 2018

1 reference

Pilot study of interferon-alpha-ribavirin-interleukin-2 for treatment of nonresponder patients with severe liver disease infected by hepatitis C virus genotype 1.

21 January 2018

1 reference

Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial

21 January 2018

1 reference

Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata

21 January 2018

1 reference

Ultra low-dose IL-2 for GVHD prophylaxis after allogeneic hematopoietic stem cell transplantation mediates expansion of regulatory T cells without diminishing antiviral and antileukemic activity.

21 January 2018

1 reference

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients

21 January 2018

1 reference

Ultra-low dose interleukin-2 promotes immune-modulating function of regulatory T cells and natural killer cells in healthy volunteers.

21 January 2018

1 reference

Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease

21 January 2018

1 reference

Low-dose IL-2 for In vivo expansion of CD4+ and CD8+ regulatory T cells in nonhuman primates

21 January 2018

1 reference

Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE.

21 January 2018

1 reference

Recovery from autoimmunity of MRL/lpr mice after infection with an interleukin-2/vaccinia recombinant virus

21 January 2018

1 reference

Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes

21 January 2018

1 reference

Sustained stimulation and expansion of Tregs by IL2 control autoimmunity without impairing immune responses to infection, vaccination and cancer

21 January 2018

1 reference

Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions

21 January 2018

1 reference

Regulatory and effector T cell activation levels are prime determinants of in vivo immune regulation

21 January 2018

1 reference

The plasticity and stability of regulatory T cells.

21 January 2018

1 reference

Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.

21 January 2018

1 reference

The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3

21 January 2018

1 reference

PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation

21 January 2018

1 reference

MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation

21 January 2018

1 reference

Local delivery of IL-2 reduces atherosclerosis via expansion of regulatory T cells.

21 January 2018

1 reference

Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis.

21 January 2018

1 reference

CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury

21 January 2018

1 reference

Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells

21 January 2018

1 reference

Eosinophils: changing perspectives in health and disease

21 January 2018

1 reference

MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion

21 January 2018

1 reference

Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance

21 January 2018

1 reference

The narrowing of the CD8 T cell repertoire in old age

21 January 2018

1 reference

An IgG3-IL2 fusion protein activates complement, binds Fc gamma RI, generates LAK activity and shows enhanced binding to the high affinity IL-2R.

21 January 2018

1 reference

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

21 January 2018

1 reference

Use of enhanced interleukin-2 formulations for improved immunotherapy against cancer.

21 January 2018

1 reference

The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma

21 January 2018

1 reference

A Lymphocyte-stimulating Factor produced in vitro

21 January 2018

1 reference

Selective in Vitro Growth of T Lymphocytes from Normal Human Bone Marrows

21 January 2018

1 reference

Long-term culture of human antigen-specific cytotoxic T-cell lines

21 January 2018

1 reference

Interleukin-2: inception, impact, and implications

21 January 2018

1 reference

Adverse drug reactions: definitions, diagnosis, and management

21 January 2018

1 reference

Natural regulatory T cells control the development of atherosclerosis in mice

21 January 2018

1 reference

A Factor stimulating DNA Synthesis derived from the Medium of Leucocyte Cultures

21 January 2018

1 reference

Re-establishing immunological self-tolerance in autoimmune disease

21 January 2018

1 reference

The role of interleukin-2 during homeostasis and activation of the immune system

31 March 2020

1 reference

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

31 March 2020

1 reference

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

31 March 2020

1 reference

T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development

31 March 2020

1 reference

Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.

31 March 2020

1 reference

Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes.

31 March 2020

1 reference

Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus

31 March 2020

1 reference

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells

31 March 2020

1 reference

Massive expansion of regulatory T-cells following interleukin 2 treatment during a phase I-II dendritic cell-based immunotherapy of metastatic renal cancer.

31 March 2020

1 reference

Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue

31 March 2020

1 reference

A T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo

31 March 2020

1 reference

Human and Mouse CD8(+)CD25(+)FOXP3(+) Regulatory T Cells at Steady State and during Interleukin-2 Therapy

31 March 2020

1 reference

In vivo administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2.

31 March 2020

1 reference

12 December 2020

Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2

1 reference

12 December 2020

IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels

1 reference

12 December 2020

X-linked lymphoreticular disease in the scurfy (sf) mutant mouse

1 reference

12 December 2020

PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs

1 reference

12 December 2020

IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation

1 reference

12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

1 reference

12 December 2020

Deficient interleukin 2 production in rheumatoid arthritis: association with active disease and systemic complications

1 reference

12 December 2020

Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI3823

1 reference

3 September 2017

1 reference