(Q38430202)

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Hedgehog inhibitor sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice

scientific article published on 08 August 2017

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scholarly article

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Europe PubMed Central

3 September 2017

Hedgehog inhibitor sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice (English)

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Europe PubMed Central

3 September 2017

1

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8 June 2020

Eva Forssell-Aronsson

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8 June 2020

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Nils Rudqvist

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8 June 2020

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Britta Langen

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8 June 2020

Toshima Z Parris

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8 June 2020

Khalil Helou

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8 June 2020

Ola Nilsson

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8 June 2020

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8 August 2017

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3 September 2017

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8 June 2020

17

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8 June 2020

528

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8 June 2020

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8 June 2020

https://scigraph.springernature.com/pub.10.1186/s12885-017-3524-x

0 references

Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5549301

6 September 2017

Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors.

1 reference

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6 September 2017

Targeting Notch to overcome radiation resistance

1 reference

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6 September 2017

PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

1 reference

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6 September 2017

GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells

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6 September 2017

Wnt/β-catenin pathway involvement in ionizing radiation-induced invasion of U87 glioblastoma cells

1 reference

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6 September 2017

Hedgehog pathway blockade with the cancer drug LDE225 disrupts taste organs and taste sensation

1 reference

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6 September 2017

The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma

1 reference

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6 September 2017

Peptide receptor radionuclide therapy for advanced neuroendocrine tumors

1 reference

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6 September 2017

Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist

1 reference

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6 September 2017

Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development

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6 September 2017

Novel insights into G protein and G protein-coupled receptor signaling in cancer

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6 September 2017

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

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6 September 2017

Radiation-induced Notch signaling in breast cancer stem cells

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6 September 2017

Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis

1 reference

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6 September 2017

Hedgehog signaling in human medullary thyroid carcinoma: a novel signaling pathway

1 reference

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6 September 2017

Bcl11a is essential for lymphoid development and negatively regulates p53.

1 reference

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6 September 2017

mTOR inhibitor RAD001 promotes metastasis in a rat model of pancreatic neuroendocrine cancer

1 reference

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6 September 2017

Phase I-II study of radiopeptide 177Lu-octreotate in combination with capecitabine and temozolomide in advanced low-grade neuroendocrine tumors

1 reference

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6 September 2017

Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2.

1 reference

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6 September 2017

Radionuclide therapy via SSTR: future aspects from experimental animal studies

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6 September 2017

The crosstalk of mTOR/S6K1 and Hedgehog pathways

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6 September 2017

Hedgehog inhibition with the orally bioavailable Smo antagonist LDE225 represses tumor growth and prolongs survival in a transgenic mouse model of islet cell neoplasms

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6 September 2017

Cdk2 is required for p53-independent G2/M checkpoint control

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6 September 2017

ICRP Publication 107. Nuclear decay data for dosimetric calculations

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6 September 2017

Hedgehog signaling in development and cancer.

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6 September 2017

One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States

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6 September 2017

Transcriptional control of human p53-regulated genes

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6 September 2017

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6 September 2017

The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1

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6 September 2017

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

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Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway

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Overexpression of p27(KIP1) induced cell cycle arrest in G(1) phase and subsequent apoptosis in HCC-9204 cell line

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6 September 2017

The physiology of p16(INK4A)-mediated G1 proliferative arrest

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6 September 2017

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6 September 2017

The sonic hedgehog-patched-gli pathway in human development and disease

1 reference

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Gene ontology: tool for the unification of biology

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Sonic hedgehog signaling protects human hepatocellular carcinoma cells against ionizing radiation in an autocrine manner

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14 September 2017

A phase I trial of the Hedgehog inhibitor, sonidegib (LDE225), in combination with etoposide and cisplatin for the initial treatment of extensive stage small cell lung cancer

1 reference

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14 September 2017

Snail and Sonic Hedgehog activation in neuroendocrine tumors of the ileum

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14 September 2017

Sonic Hedgehog-Gli1 signaling pathway might become an effective therapeutic target in gastrointestinal neuroendocrine carcinomas

1 reference

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1 reference

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23 June 2018

Peptide receptor radionuclide therapy with 177Lu-DOTATATE for patients with somatostatin receptor-expressing neuroendocrine tumors: the first US phase 2 experience.

1 reference

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31 August 2018

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1 reference

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31 August 2018

[177Lu-DOTA 0-Tyr 3]-octreotate treatment in patients with disseminated gastroenteropancreatic neuroendocrine tumors: the value of measuring absorbed dose to the kidney

1 reference

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1 reference

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31 August 2018

Comparison of [177Lu-DOTA0,Tyr3]-octreotate and [177Lu-DOTA0,Tyr3]-octreotide for receptor-mediated radiation therapy of the xenografted human midgut carcinoid tumor GOT1.

1 reference

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31 August 2018

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1 reference

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31 August 2018

Successful receptor-mediated radiation therapy of xenografted human midgut carcinoid tumour

1 reference

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31 August 2018

GOT1 xenografted to nude mice: a unique model for in vivo studies on SSTR-mediated radiation therapy of carcinoid tumors

1 reference

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31 August 2018

Biodistribution of 111in-DTPA-D-Phe1-octreotide in tumor-bearing nude mice: influence of amount injected and route of administration

1 reference

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31 August 2018

[177Lu-DOTA(0),Tyr3] octreotate for somatostatin receptor-targeted radionuclide therapy

1 reference

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31 August 2018

In the book of life, the answers aren't in the back--Charlie Brown, fictional character of the Peanuts comic strip created by Charles Schulz.

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21 January 2018

Identifiers

10.1186/S12885-017-3524-X

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8 June 2020

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8 June 2020

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8 June 2020

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