(Q38435784)

English

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

scientific article published on 21 August 2016

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scholarly article

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Europe PubMed Central

PMC publication ID

3 September 2017

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway (English)

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Europe PubMed Central

PMC publication ID

3 September 2017

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insulin resistance

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based on heuristic

inferred from title

4

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1 June 2020

author name string

Sarbani Ghoshal

1

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1 June 2020

Qingzhang Zhu

2

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1 June 2020

Alice Asteian

3

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1 June 2020

Haifei Xu

5

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1 June 2020

Glen Ernst

6

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James C Barrow

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Baoji Xu

8

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1 June 2020

Michael D Cameron

9

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1 June 2020

Theodore M Kamenecka

10

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Anutosh Chakraborty

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1 June 2020

publication date

21 August 2016

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Molecular Metabolism

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1 June 2020

5

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1 June 2020

10

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1 June 2020

903-917

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1 June 2020

describes a project that uses

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11 June 2022

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Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport

1 reference

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Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis

1 reference

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1 reference

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Brown adipose tissue as an anti-obesity tissue in humans

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Antiobesity pharmacotherapy: new drugs and emerging targets

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Brown and beige fat: development, function and therapeutic potential

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Inositol pyrophosphates: between signalling and metabolism

1 reference

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Pharmacological strategies for targeting BAT thermogenesis.

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Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate

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Pharmacotherapy of obesity: clinical treatments and considerations.

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Adaptive thermogenesis with weight loss in humans

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Do we need anti-obesity drugs?

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Kinase drug discovery--what's next in the field?

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Anti-obesity drugs: past, present and future

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IP3 3-kinase opposes NGF driven neurite outgrowth

1 reference

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Laboratory animals as surrogate models of human obesity

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A guide to analysis of mouse energy metabolism

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Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding

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Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway

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Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

1 reference

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Zinc release from thapsigargin/IP3-sensitive stores in cultured cortical neurons

1 reference

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Brown fat as a therapy for obesity and diabetes

1 reference

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betaAR signaling required for diet-induced thermogenesis and obesity resistance

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Obesity and insulin resistance

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6 September 2017

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1 reference

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14 September 2017

Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells

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23 June 2018

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23 June 2018

Recruited brown adipose tissue as an antiobesity agent in humans

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23 June 2018

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23 June 2018

Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain

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23 June 2018

Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects

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23 June 2018

A role for brown adipose tissue in diet-induced thermogenesis

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23 June 2018

A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034689

23 June 2018

Optimizing sampling designs for volume measurements of components of human brain using a stereological method.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034689

23 June 2018

Inositol Hexakisphosphate Kinase-3 Regulates the Morphology and Synapse Formation of Cerebellar Purkinje Cells via Spectrin/Adducin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034689

31 August 2018

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034689

31 August 2018

Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034689

31 August 2018

Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034689

31 August 2018

Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034689

31 August 2018

Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034689

31 August 2018

Influence of inositol pyrophosphates on cellular energy dynamics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034689

31 August 2018

Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5034689

31 August 2018

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689003

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689003

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Do we need new drugs for the treatment of type 2 diabetes mellitus?

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689003

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low-density lipoprotein receptor knockout mice exhibit exaggerated microvascular responses to inflammatory stimuli

1 reference

https://pubmed.ncbi.nlm.nih.gov/27689003

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MOLMET.2016.08.008

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27689003%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

release_vzfmb3dp6zb4xnvw5p545b7jke

1 reference

https://api.fatcat.wiki/v0/release/vzfmb3dp6zb4xnvw5p545b7jke

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27689003%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27689003%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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