(Q38522584)

3 September 2017

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title

The use of 'Omics technology to rationally improve industrial mammalian cell line performance (English)

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3 September 2017

Amanda M Lewis

1

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3 September 2017

Nicholas R Abu-Absi

series ordinal

2

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3 September 2017

Michael C Borys

series ordinal

3

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3 September 2017

Zheng Jian Li

series ordinal

4

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3 September 2017

publication date

9 June 2015

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Biotechnology and Bioengineering

3 September 2017

published in

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3 September 2017

volume

113

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3 September 2017

issue

1

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3 September 2017

page(s)

26-38

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Parallel labeling experiments with [1,2-(13)C]glucose and [U-(13)C]glutamine provide new insights into CHO cell metabolism

3 September 2017

cites work

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Merging multiple omics datasets in silico: statistical analyses and data interpretation

21 January 2018

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21 January 2018

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Proteomic analysis of Chinese hamster ovary cells

21 January 2018

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Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing

21 January 2018

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Dynamic mRNA and miRNA profiling of CHO-K1 suspension cell cultures.

21 January 2018

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Fermentanomics: monitoring mammalian cell cultures with NMR spectroscopy

21 January 2018

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Proteomic profiling of a high-producing Chinese hamster ovary cell culture

21 January 2018

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LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells.

21 January 2018

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Metabolomics for high-resolution monitoring of the cellular physiological state in cell culture engineering.

21 January 2018

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Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity

21 January 2018

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Predicting cell-specific productivity from CHO gene expression.

21 January 2018

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CGCDB: a web-based resource for the investigation of gene coexpression in CHO cell culture

21 January 2018

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Translatome analysis of CHO cells to identify key growth genes

21 January 2018

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An 'omics approach towards CHO cell engineering.

21 January 2018

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Systems biology of yeast: enabling technology for development of cell factories for production of advanced biofuels

21 January 2018

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Metabolite profiling of CHO cells with different growth characteristics.

21 January 2018

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Mammalian cells as biopharmaceutical production hosts in the age of omics

21 January 2018

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Transcriptomic analysis of clonal growth rate variation during CHO cell line development

21 January 2018

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A novel microRNA mmu-miR-466h affects apoptosis regulation in mammalian cells

21 January 2018

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Paintomics: a web based tool for the joint visualization of transcriptomics and metabolomics data

21 January 2018

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Genomic sequencing and analysis of a Chinese hamster ovary cell line using Illumina sequencing technology

21 January 2018

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21 January 2018

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Cell line profiling to improve monoclonal antibody production.

21 January 2018

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Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment

21 January 2018

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Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells

21 January 2018

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The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology

21 January 2018

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CHO cells in biotechnology for production of recombinant proteins: current state and further potential

21 January 2018

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21 January 2018

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Identification and characterization of host cell protein product-associated impurities in monoclonal antibody bioprocessing

21 January 2018

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Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome

21 January 2018

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Identification of autocrine growth factors secreted by CHO cells for applications in single-cell cloning media

21 January 2018

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21 January 2018

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Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

21 January 2018

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A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism

21 January 2018

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Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics.

21 January 2018

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Metabolomics profiling of extracellular metabolites in CHO-K1 cells cultured in different types of growth media

21 January 2018

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Stable isotope-assisted metabolomics to detect metabolic flux changes in mammalian cell cultures

21 January 2018

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Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation

21 January 2018

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Glycomics profiling of Chinese hamster ovary cell glycosylation mutants reveals N-glycans of a novel size and complexity

21 January 2018

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Proteome analysis of antibody-producing CHO cell lines with different metabolic profiles

21 January 2018

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Innovation: Metabolomics: the apogee of the omics trilogy

21 January 2018

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A ratiometric lectin microarray approach to analysis of the dynamic mammalian glycome

21 January 2018

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Construction of a public CHO cell line transcript database using versatile bioinformatics analysis pipelines

21 January 2018

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Systems biology and "omics" tools: a cooperation for next-generation mycorrhizal studies

21 January 2018

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CHO gene expression profiling in biopharmaceutical process analysis and design

21 January 2018

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Metabolite profiling of recombinant CHO cells: designing tailored feeding regimes that enhance recombinant antibody production.

21 January 2018

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Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture.

21 January 2018

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Stable microRNA expression enhances therapeutic antibody productivity of Chinese hamster ovary cells

21 January 2018

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DanteR: an extensible R-based tool for quantitative analysis of -omics data

21 January 2018

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Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture.

21 January 2018

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The characterization and quantitation of glycomic changes in CHO cells during a bioreactor campaign

21 January 2018

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Expression of difficult-to-remove host cell protein impurities during extended Chinese hamster ovary cell culture and their impact on continuous bioprocessing.

21 January 2018

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Recovery of Chinese hamster ovary host cell proteins for proteomic analysis.

21 January 2018

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Translating cancer 'omics' to improved outcomes

21 January 2018

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Genomics in mammalian cell culture bioprocessing

21 January 2018

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INMEX--a web-based tool for integrative meta-analysis of expression data

21 January 2018

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The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

21 January 2018

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Metabolic flux rewiring in mammalian cell cultures

21 January 2018

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Effects of copper on CHO cells: insights from gene expression analyses

21 January 2018

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anNET: a tool for network-embedded thermodynamic analysis of quantitative metabolome data

21 January 2018

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Metabolomics profiling of cell culture media leading to the identification of riboflavin photosensitized degradation of tryptophan causing slow growth in cell culture.

21 January 2018

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Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIT.25673

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3 September 2017

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