(Q38530624)

3 September 2017

1 reference

title

Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity (English)

1 reference

3 September 2017

2

1 reference

3 September 2017

Fiachra Humphries

1

1 reference

3 September 2017

1 July 2015

1 reference

3 September 2017

Immunological Reviews

1 reference

3 September 2017

266

1 reference

3 September 2017

1

1 reference

3 September 2017

93-108

1 reference

The history of Toll-like receptors - redefining innate immunity.

3 September 2017

1 reference

NOD-like receptors: role in innate immunity and inflammatory disease

21 January 2018

1 reference

TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway

21 January 2018

1 reference

A cell biological view of Toll-like receptor function: regulation through compartmentalization.

21 January 2018

1 reference

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

21 January 2018

1 reference

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

21 January 2018

1 reference

TRAF6 is a signal transducer for interleukin-1

21 January 2018

1 reference

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

21 January 2018

1 reference

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

21 January 2018

1 reference

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 January 2018

1 reference

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

1 reference

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

1 reference

21 January 2018

The NF-kappaB pathway

1 reference

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

21 January 2018

1 reference

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation

21 January 2018

1 reference

RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation

21 January 2018

1 reference

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

21 January 2018

1 reference

Drosophila innate immunity: an evolutionary perspective

21 January 2018

1 reference

A heterotrimeric death domain complex in Toll signaling

21 January 2018

1 reference

Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning

21 January 2018

1 reference

Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor

21 January 2018

1 reference

Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections

21 January 2018

1 reference

The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila

21 January 2018

1 reference

Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal

21 January 2018

1 reference

Pellino enhances innate immunity in Drosophila.

21 January 2018

1 reference

Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signalling by controlling MyD88 turnover in Drosophila.

21 January 2018

1 reference

Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling

21 January 2018

1 reference

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex

21 January 2018

1 reference

Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein

21 January 2018

1 reference

21 January 2018

1 reference

Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping

21 January 2018

1 reference

Characterization of Pellino2, a substrate of IRAK1 and IRAK4

21 January 2018

1 reference

Pellino2 activates the mitogen activated protein kinase pathway

21 January 2018

1 reference

Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases

21 January 2018

1 reference

Pellino Proteins Contain a Cryptic FHA Domain that Mediates Interaction with Phosphorylated IRAK1

21 January 2018

1 reference

Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases

21 January 2018

1 reference

The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

21 January 2018

1 reference

Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner

21 January 2018

1 reference

RING finger proteins: mediators of ubiquitin ligase activity

21 January 2018

1 reference

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint

21 January 2018

1 reference

The FHA domain is a modular phosphopeptide recognition motif.

21 January 2018

1 reference

The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities

21 January 2018

1 reference

Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.

21 January 2018

1 reference

Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression

21 January 2018

1 reference

Pellino-1, an adaptor protein of interleukin-1 receptor/toll-like receptor signaling, is sumoylated by Ubc9.

21 January 2018

1 reference

The role of TBK1 and IKKε in the expression and activation of Pellino 1.

21 January 2018

1 reference

Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD.

21 January 2018

1 reference

Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production

21 January 2018

1 reference

Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination.

21 January 2018

1 reference

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

21 January 2018

1 reference

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

21 January 2018

1 reference

Triggering the interferon antiviral response through an IKK-related pathway

21 January 2018

1 reference

Pellino-1 selectively regulates epithelial cell responses to rhinovirus.

21 January 2018

1 reference

Pellino1 is required for interferon production by viral double-stranded RNA.

21 January 2018

1 reference

DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA.

21 January 2018

1 reference

Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons

21 January 2018

1 reference

TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1

21 January 2018

1 reference

Proteomic and transcriptomic analyses of macrophages with an increased resistance to oxidized low density lipoprotein (oxLDL)-induced cytotoxicity generated by chronic exposure to oxLDL.

21 January 2018

1 reference

OxLDL inhibits LPS-induced IFNβ expression by Pellino3- and IRAK1/4-dependent modification of TANK.

21 January 2018

1 reference

A poxviral homolog of the Pellino protein inhibits Toll and Toll-like receptor signalling.

21 January 2018

1 reference

Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control

21 January 2018

1 reference

BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2

21 January 2018

1 reference

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis

21 January 2018

1 reference

Nod-like receptors in the control of intestinal inflammation.

21 January 2018

1 reference

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

1 reference

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

1 reference

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

21 January 2018

1 reference

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 January 2018

1 reference

Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide

21 January 2018

1 reference

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains

21 January 2018

1 reference

NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.

21 January 2018

1 reference

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

21 January 2018

1 reference

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

21 January 2018

1 reference

XIAP mediates NOD signaling via interaction with RIP2

21 January 2018

1 reference

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways

21 January 2018

1 reference

RIP kinases: key decision makers in cell death and innate immunity

21 January 2018

1 reference

The roles of Pellino E3 ubiquitin ligases in immunity

21 January 2018

1 reference

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

21 January 2018

1 reference

Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.

21 January 2018

1 reference

Smad7 and Smad6 bind to discrete regions of Pellino-1 via their MH2 domains to mediate TGF-beta1-induced negative regulation of IL-1R/TLR signaling

21 January 2018

1 reference

Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation

21 January 2018

1 reference

Mal mediates TLR-induced activation of CREB and expression of IL-10.

21 January 2018

1 reference

Signalling pathways of the TNF superfamily: a double-edged sword

21 January 2018

1 reference

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

21 January 2018

1 reference

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

21 January 2018

1 reference

TNF-R1 signaling: a beautiful pathway

21 January 2018

1 reference

Nuclear factor-kappaB in cancer development and progression

21 January 2018

1 reference

Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction

21 January 2018

1 reference

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

21 January 2018

1 reference

NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

21 January 2018

1 reference

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

1 reference

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

1 reference

RIP kinases at the crossroads of cell death and survival

21 January 2018

1 reference

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

21 January 2018

1 reference

Death receptor signal transducers: nodes of coordination in immune signaling networks

21 January 2018

1 reference

Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α

21 January 2018

1 reference

Mediators of neutrophil function in children with protracted bacterial bronchitis.

21 January 2018

1 reference

Toll-like receptors-related genes in kidney transplant patients with chronic allograft nephropathy and acute rejection.

21 January 2018

1 reference

Assessment of risk factors for Korean children with Kawasaki disease

21 January 2018

1 reference

A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease

21 January 2018

1 reference

The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity

21 January 2018

1 reference

Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

21 January 2018

1 reference

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

21 January 2018

1 reference

Silencing of Pellino1 improves post-infarct cardiac dysfunction and attenuates left ventricular remodelling in mice

21 January 2018

1 reference

Pellino1-mediated TGF-β1 synthesis contributes to mechanical stress induced cardiac fibroblast activation

21 January 2018

1 reference

BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis

21 January 2018

1 reference

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas

21 January 2018

1 reference

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

21 January 2018

1 reference

The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance.

21 January 2018

1 reference

Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family

21 January 2018

1 reference

How biologics targeting the IL-1 system are being considered for the treatment of type 2 diabetes

21 January 2018

1 reference

NF-κB, inflammation, and metabolic disease.

21 January 2018

1 reference

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

21 January 2018

1 reference

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

1 reference

Adipose tissue oxygenation: Effects on metabolic function

21 January 2018

1 reference

Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity

21 January 2018

1 reference

Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide.

21 January 2018

1 reference

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

21 January 2018

1 reference

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

21 January 2018

1 reference

Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/IMR.12306

1 reference

3 September 2017

1 reference

PubMed ID

26085209