(Q38559613)

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Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

scientific article published on 19 February 2016

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Europe PubMed Central

PMC publication ID

4 September 2017

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site (English)

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Europe PubMed Central

PMC publication ID

4 September 2017

Christoph Becker-Pauly

12

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Christoph Becker-Pauly

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3

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Simone Isbert

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Stefan F Lichtenthaler

9

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Stefan F Lichtenthaler

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Europe PubMed Central

PMC publication ID

4 September 2017

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Sathish Kumar

7

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Markus Glatzel

11

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Caroline Schönherr

1

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Jessica Bien

2

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Europe PubMed Central

PMC publication ID

4 September 2017

Simone Isbert

3

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Rielana Wichert

4

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Johannes Prox

5

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Hermann Altmeppen

6

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Jochen Walter

8

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Sascha Weggen

10

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Christoph Becker-Pauly

12

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

Claus U Pietrzik

13

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Europe PubMed Central

PMC publication ID

4 September 2017

publication date

19 February 2016

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Europe PubMed Central

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4 September 2017

Molecular Neurodegeneration

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Europe PubMed Central

PMC publication ID

4 September 2017

11

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Europe PubMed Central

PMC publication ID

4 September 2017

19

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Europe PubMed Central

PMC publication ID

4 September 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4759862/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Calcium negatively regulates meprin β activity and attenuates substrate cleavage

1 reference

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The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation

1 reference

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Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

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1 reference

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Metalloproteases meprin α and meprin β are C- and N-procollagen proteinases important for collagen assembly and tensile strength

1 reference

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N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits

1 reference

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The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

1 reference

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

1 reference

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Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

1 reference

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Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease

1 reference

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Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates

1 reference

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Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo

1 reference

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Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

1 reference

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Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry.

1 reference

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Pyroglutamate-Aβ: Role in the natural history of Alzheimer's disease

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1 reference

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Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge.

1 reference

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain

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6 September 2017

Signals for sorting of transmembrane proteins to endosomes and lysosomes

1 reference

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6 September 2017

Probing the active sites and mechanisms of rat metalloproteases meprin A and B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

6 September 2017

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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6 September 2017

Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

6 September 2017

Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.

1 reference

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

6 September 2017

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

6 September 2017

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

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6 September 2017

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

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6 September 2017

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

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Cellular mechanisms of beta-amyloid production and secretion

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

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Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

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On the size of the active site in proteases. I. Papain

1 reference

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

6 September 2017

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

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Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

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Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

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1 reference

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Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein

1 reference

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23 June 2018

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

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The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

23 June 2018

Structural design, solid-phase synthesis and activity of membrane-anchored β-secretase inhibitors on Aβ generation from wild-type and Swedish-mutant APP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

23 June 2018

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

23 June 2018

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

23 June 2018

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

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Stx5 is a novel interactor of VLDL-R to affect its intracellular trafficking and processing

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

31 August 2018

Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

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gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

31 August 2018

alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

31 August 2018

Urea-based two-dimensional electrophoresis of beta-amyloid peptides in human plasma: evidence for novel Abeta species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

31 August 2018

A novel monoclonal antibody specific for the amino-truncated beta-amyloid Abeta5-40/42 produced from caspase-cleaved amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

31 August 2018

BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

31 August 2018

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

31 August 2018

Electrophoretic separation of amyloid beta peptides in plasma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

31 August 2018

Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

31 August 2018

Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

31 August 2018

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

1 reference

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1 reference

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Differences in the activation mechanism between the alpha and beta subunits of human meprin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759862

31 August 2018

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1 reference

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31 August 2018

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease

1 reference

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31 August 2018

Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/26895626

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/26895626

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrophoretic Separation of βA4 Peptides (1–40) and (1–42)

1 reference

https://pubmed.ncbi.nlm.nih.gov/26895626

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

https://pubmed.ncbi.nlm.nih.gov/26895626

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S13024-016-0084-5

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

4 September 2017

ResearchGate publication ID

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