(Q42785839)

English

Structural design, solid-phase synthesis and activity of membrane-anchored β-secretase inhibitors on Aβ generation from wild-type and Swedish-mutant APP.

scientific article published on December 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Structural design, solid-phase synthesis and activity of membrane-anchored β-secretase inhibitors on Aβ generation from wild-type and Swedish-mutant APP. (English)

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Hans-Joachim Knölker

9

object named as

Hans-Joachim Knölker

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

author name string

Heinke Schieb

1

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Sebastian Weidlich

2

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Georg Schlechtingen

3

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Philipp Linning

4

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Gary Jennings

5

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Margit Gruner

6

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Hans-Wolfgang Klafki

8

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

language of work or name

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publication date

1 December 2010

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

Chemistry—A European Journal

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Europe PubMed Central

PubMed publication ID

7 November 2017

16

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

48

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

14412-14423

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Europe PubMed Central

PubMed publication ID

7 November 2017

Intramembrane proteolysis by presenilins

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Human β-Secretase (BACE) and BACE Inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Maturation and pro-peptide cleavage of beta-secretase

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Phosphorylation regulates intracellular trafficking of beta-secretase

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Functional rafts in cell membranes

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Structure and origin of ordered lipid domains in biological membranes.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Structure and function of sphingolipid- and cholesterol-rich membrane rafts

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Lipid rafts and signal transduction

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Domains and rafts in lipid membranes

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Model systems, lipid rafts, and cell membranes

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Lipid rafts as a membrane-organizing principle

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Efficient inhibition of the Alzheimer's disease beta-secretase by membrane targeting

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Subcellular targeting strategies for drug design and delivery

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Design of substrate-based inhibitors of human beta-secretase

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Apical sorting of beta-secretase limits amyloid beta-peptide production

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

The uronium/guanidinium Peptide coupling reagents: finally the true uronium salts

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Generation of amyloid β protein from its precursor is sequence specific

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

beta-Secretase inhibitor potency is decreased by aberrant beta-cleavage location of the "Swedish mutant" amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Amino-truncated beta-amyloid42 peptides in cerebrospinal fluid and prediction of progression of mild cognitive impairment

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Urea-based two-dimensional electrophoresis of beta-amyloid peptides in human plasma: evidence for novel Abeta species

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Increased generation of alternatively cleaved beta-amyloid peptides in cells expressing mutants of the amyloid precursor protein defective in endocytosis

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Morphological and biochemical maturation of neurones cultured in the absence of glial cells

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

The Effect of Sterol Structure on Membrane Lipid Domains Reveals How Cholesterol Can Induce Lipid Domain Formation†

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Electrophoretic Separation of βA4 Peptides (1–40) and (1–42)

1 reference

https://api.crossref.org/works/10.1002%2FCHEM.201002878

21 January 2018

Identifiers

10.1002/CHEM.201002878

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

ResearchGate publication ID

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