(Q40763877)

23 September 2017

title

Apical sorting of beta-secretase limits amyloid beta-peptide production (English)

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23 September 2017

6

Christian Haass

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Anja Capell

series ordinal

1

object named as

Anja Capell

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23 September 2017

3

Regina Fluhrer

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23 September 2017

Liane Meyn

2

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23 September 2017

David B Teplow

series ordinal

4

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23 September 2017

Jochen Walter

series ordinal

5

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23 September 2017

language of work or name

English

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publication date

6 December 2001

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Journal of Biological Chemistry

23 September 2017

number of pages

7

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based on heuristic

inferred from page(s)

published in

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23 September 2017

volume

277

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23 September 2017

issue

7

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23 September 2017

page(s)

5637-5643

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Intramembrane proteolysis by presenilins

23 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109119200

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1 reference

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

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Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

21 January 2018

1 reference

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Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

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Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease

21 January 2018

1 reference

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

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Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

21 January 2018

1 reference

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

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Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture

21 January 2018

1 reference

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Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease

21 January 2018

1 reference

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Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells

21 January 2018

1 reference

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Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals

21 January 2018

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Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons

21 January 2018

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

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Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

21 January 2018

1 reference

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Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

1 reference

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Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

21 January 2018

1 reference

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

1 reference

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Generation of amyloid beta protein from its precursor is sequence specific

21 January 2018

1 reference

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Processing of beta-secretase by furin and other members of the proprotein convertase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109119200

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

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Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

1 reference

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A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109119200

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109119200

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109119200

Mechanisms of cell polarity: sorting and transport in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109119200

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109119200

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109119200

21 January 2018

Identifiers

DOI

10.1074/JBC.M109119200

1 reference

23 September 2017

1 reference