(Q38560646)

4 September 2017

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title

Drug chirality and its clinical significance (English)

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4 September 2017

Hutt AJ

1

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4 September 2017

Tan SC

series ordinal

2

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4 September 2017

publication date

1 January 1996

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4 September 2017

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4 September 2017

volume

52 Suppl 5

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4 September 2017

page(s)

1-12

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The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences

4 September 2017

cites work

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The activity of verapamil as a resistance modifier in vitro in drug resistant human tumour cell lines is not stereospecific.

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Stereoselective delivery and actions of beta receptor antagonists

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Importance of drug enantiomers in clinical pharmacology

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Penicillamine, a new oral therapy for Wilson's disease

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Stereochemistry: a source of problems in medicinal chemistry

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Interindividual variability in the enantiomeric disposition of ibuprofen following the oral administration of the racemic drug to healthy volunteers

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12 December 2020

On the other hand: the stereoselectivity of drug action at ion channels

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Pharmacology of enantiomers and (–) p-OH metabolite of indacrinone

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Enantiomers in arthritic disorders

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Non-confirmation of thalidomide induced teratogenesis in rats and mice

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Enhancement of uricosuric properties of indacrinone by manipulation of the enantiomer ratio

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Mutagenicity of cysteine and penicillamine and its enantiomeric selectivity.

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Effects of dilevalol, an R, R-isomer of labetalol, on blood pressure and renal function in patients with mild-to-moderate essential hypertension

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Stereoselectivity of bioactive xenobiotics. A pre-Pasteur attitude in medicinal chemistry, pharmacokinetics and clinical pharmacology

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Lack of effect of ageing on the stereochemical disposition of propranolol

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Toxicity and Teratogenicity of Optical Isomers of Thalidomide

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Current regulatory (draft) guidance on chiral medicinal products: Canada, EEC, Japan, United States

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Chirality of penicillamine

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DL-penicillamine as a cause of optic axial neuritis

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Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology

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Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs

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Stereoselectivity in pharmacokinetics: a general theory

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Stereoselective disposition of flecainide in relation to the sparteine/debrisoquine metaboliser phenotype

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Resistance to multiple chemotherapeutic agents in human cancer cells

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Disposition of ibuprofen in patients with liver cirrhosis. Stereochemical considerations

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Pharmacodynamic, Pharmacokinetic and Antiarrhythmic Properties of d-Sotalol, the Dextro-Isomer of Sotalol

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Effects of D-timolol and L-timolol on ocular blood flow and intraocular pressure.

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Respiratory effects of timolol

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Bronchial beta-adrenoceptor blockade following eyedrops of timolol and its isomer L-714,465 in normal subjects

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Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers

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The FDA perspective on the development of stereoisomers

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The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequences

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Chromatographic separation of racemic thalidomide and teratogenic activity of its enantiomers (author's transl)

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Stereoselectivity and Affinity in Molecular Pharmacology

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Pharmacokinetic and pharmacodynamic consequences of stereoselective drug metabolism in man.

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Enantiomer specific pharmacokinetics

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The so-called "interconversion" of stereoisomeric drugs: an attempt at clarification

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12 December 2020

Variations of optical rotation of naproxen: polarimetric determination in the presence of nonchiral basic compounds

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12 December 2020

The influence of age and gender on the stereoselective metabolism and pharmacokinetics of mephobarbital in humans

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12 December 2020

Plasma propranolol levels in the quaniitative assessment of beta-adrenergic blockade in man

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12 December 2020

The alpha- and beta-adrenoceptor blocking potencies of labetalol and its individual stereoisomers in anaesthetized dogs and in isolated tissues

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12 December 2020

Identifiers

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