(Q38590007)

4 September 2017

title

Immune defence against Candida fungal infections (English)

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4 September 2017

1

Mihai G Netea

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4 September 2017

2

Leo A B Joosten

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4 September 2017

Jos W. M. van der Meer,

series ordinal

3

object named as

Jos W M van der Meer

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4 September 2017

Bart-Jan Kullberg

4

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4 September 2017

Frank L van de Veerdonk

series ordinal

5

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4 September 2017

publication date

21 September 2015

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4 September 2017

number of pages

13

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Nature Reviews Immunology

inferred from page(s)

published in

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4 September 2017

volume

15

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4 September 2017

issue

10

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4 September 2017

page(s)

630-642

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Tackling Human Fungal Infections

4 September 2017

cites work

1 reference

Attributable mortality of nosocomial candidemia, revisited

21 January 2018

1 reference

Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study

21 January 2018

1 reference

Chemical structure of the cell-wall mannan of Candida albicans serotype A and its difference in yeast and hyphal forms

21 January 2018

1 reference

Novel structural features in Candida albicans hyphal glucan provide a basis for differential innate immune recognition of hyphae versus yeast.

21 January 2018

1 reference

Masking of β(1-3)-glucan in the cell wall of Candida albicans from detection by innate immune cells depends on phosphatidylserine.

21 January 2018

1 reference

Immune recognition. A new receptor for beta-glucans

21 January 2018

1 reference

Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'.

21 January 2018

1 reference

Dectin-1 is a major beta-glucan receptor on macrophages

21 January 2018

1 reference

Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.

21 January 2018

1 reference

The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infections

21 January 2018

1 reference

Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity

21 January 2018

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A homozygous CARD9 mutation in a family with susceptibility to fungal infections

21 January 2018

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Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity

21 January 2018

1 reference

Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.

21 January 2018

1 reference

Dectin-1 mediates the biological effects of beta-glucans

21 January 2018

1 reference

Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages

21 January 2018

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Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2.

21 January 2018

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Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

21 January 2018

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Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1

21 January 2018

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Human genetic susceptibility to invasive aspergillosis

21 January 2018

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Genetic susceptibility to Candida infections

21 January 2018

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Human dectin-1 deficiency and mucocutaneous fungal infections

21 January 2018

1 reference

IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis

21 January 2018

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Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency.

21 January 2018

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The role of Syk/CARD9 coupled C-type lectins in antifungal immunity

21 January 2018

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Complement receptor 3, not Dectin-1, is the major receptor on human neutrophils for beta-glucan-bearing particles

21 January 2018

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Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects.

21 January 2018

1 reference

An anti-inflammatory property of Candida albicans β-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism

21 January 2018

1 reference

The Mnn2 mannosyltransferase family modulates mannoprotein fibril length, immune recognition and virulence of Candida albicans

21 January 2018

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Dendritic cell interaction with Candida albicans critically depends on N-linked mannan.

21 January 2018

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Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans

21 January 2018

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The macrophage mannose receptor induces IL-17 in response to Candida albicans.

21 January 2018

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C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia

21 January 2018

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An integrated model of the recognition of Candida albicans by the innate immune system.

21 January 2018

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Role of Dectin-2 for host defense against systemic infection with Candida glabrata.

21 January 2018

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C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection

21 January 2018

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Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling.

21 January 2018

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Galectin-3 plays an important role in protection against disseminated candidiasis

21 January 2018

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The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans

21 January 2018

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The potential role of mannan-binding lectin in the clearance of self-components including immune complexes

21 January 2018

1 reference

Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36

21 January 2018

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Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation.

21 January 2018

1 reference

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

21 January 2018

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The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections

21 January 2018

1 reference

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

21 January 2018

1 reference

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

21 January 2018

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An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans

21 January 2018

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Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome

21 January 2018

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The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

21 January 2018

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Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

21 January 2018

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Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

21 January 2018

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Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans

21 January 2018

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Candida albicans triggers NLRP3-mediated pyroptosis in macrophages.

21 January 2018

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The pathogen Candida albicans hijacks pyroptosis for escape from macrophages

21 January 2018

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A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans

21 January 2018

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Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages

21 January 2018

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Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans

21 January 2018

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Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

21 January 2018

1 reference

Inflammasome-independent regulation of IL-1-family cytokines

21 January 2018

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Host defence against disseminated Candida albicans infection and implications for antifungal immunotherapy

21 January 2018

1 reference

Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice

21 January 2018

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Fungal morphogenesis and host invasion

21 January 2018

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Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo

21 January 2018

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Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae

21 January 2018

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Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments.

21 January 2018

1 reference

Two unlike cousins: Candida albicans and C. glabrata infection strategies

21 January 2018

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A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells.

21 January 2018

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Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells.

21 January 2018

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IL-22 and TNF-α represent a key cytokine combination for epidermal integrity during infection with Candida albicans.

21 January 2018

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β-Defensin 1 plays a role in acute mucosal defense against Candida albicans

21 January 2018

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Inflammatory monocytes mediate early and organ-specific innate defense during systemic candidiasis.

21 January 2018

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CX3CR1-dependent renal macrophage survival promotes Candida control and host survival

21 January 2018

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CX3CR1 is dispensable for control of mucosal Candida albicans infections in mice and humans

21 January 2018

1 reference

Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry

21 January 2018

1 reference

Innate antifungal immunity: the key role of phagocytes

21 January 2018

1 reference

Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans

21 January 2018

1 reference

Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection

21 January 2018

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Clinical manifestation of myeloperoxidase deficiency

21 January 2018

1 reference

Neutrophil function: from mechanisms to disease

21 January 2018

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NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus

21 January 2018

1 reference

Killing by neutrophil extracellular traps: fact or folklore?

21 January 2018

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Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans

21 January 2018

1 reference

Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3

21 January 2018

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Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease

21 January 2018

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Dual functions of the human antimicrobial peptide LL-37-target membrane perturbation and host cell cargo delivery

21 January 2018

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Human antimicrobial peptide LL-37 inhibits adhesion of Candida albicans by interacting with yeast cell-wall carbohydrates

21 January 2018

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The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils

21 January 2018

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An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7.

21 January 2018

1 reference

Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes.

21 January 2018

1 reference

Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans

21 January 2018

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Role of autophagy genetic variants for the risk of Candida infections.

21 January 2018

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Autophagy is redundant for the host defense against systemic Candida albicans infections.

21 January 2018

1 reference

Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense

21 January 2018

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Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice

21 January 2018

1 reference

Human natural killer cells acting as phagocytes against Candida albicans and mounting an inflammatory response that modulates neutrophil antifungal activity

21 January 2018

1 reference

Interferon-β production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans.

21 January 2018

1 reference

Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling

21 January 2018

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Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.

21 January 2018

1 reference

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity

21 January 2018

1 reference

Recombinant interleukin-18 protects against disseminated Candida albicans infection in mice

21 January 2018

1 reference

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

21 January 2018

1 reference

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

21 January 2018

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Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice

21 January 2018

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Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

21 January 2018

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Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

21 January 2018

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STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis

21 January 2018

1 reference

Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

21 January 2018

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Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity

21 January 2018

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The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway.

21 January 2018

1 reference

STAT3 mutations in the hyper-IgE syndrome

21 January 2018

1 reference

Secukinumab in plaque psoriasis--results of two phase 3 trials.

21 January 2018

1 reference

Defective antifungal T-helper 1 (TH1) immunity in a murine model of allogeneic T-cell-depleted bone marrow transplantation and its restoration by treatment with TH2 cytokine antagonists.

21 January 2018

1 reference

Endogenous interleukin 4 is required for development of protective CD4+ T helper type 1 cell responses to Candida albicans

21 January 2018

1 reference

Innate lymphoid cells--a proposal for uniform nomenclature

21 January 2018

1 reference

Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection

21 January 2018

1 reference

Oral-resident natural Th17 cells and γδ T cells control opportunistic Candida albicans infections

21 January 2018

1 reference

Complement C3 plays an essential role in the control of opportunistic fungal infections

21 January 2018

1 reference

Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain

21 January 2018

1 reference

Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence

21 January 2018

1 reference

Adherence of platelets to Candida species in vivo

21 January 2018

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Antimicrobial activity of pure platelet-rich plasma against microorganisms isolated from oral cavity

21 January 2018

1 reference

Candida vaginitis: when opportunism knocks, the host responds

21 January 2018

1 reference

Thriving within the host: Candida spp. interactions with phagocytic cells

21 January 2018

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Persistence versus escape: Aspergillus terreus and Aspergillus fumigatus employ different strategies during interactions with macrophages

21 January 2018

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Proteomic characterization of human proinflammatory M1 and anti-inflammatory M2 macrophages and their response to Candida albicans.

21 January 2018

1 reference

Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.

21 January 2018

1 reference

Toll-like receptor 2 controls expansion and function of regulatory T cells

21 January 2018

1 reference

Systems biology of host-fungus interactions: turning complexity into simplicity

21 January 2018

1 reference

An Interspecies Regulatory Network Inferred from Simultaneous RNA-seq of Candida albicans Invading Innate Immune Cells

21 January 2018

1 reference

Transcriptome profile of the vascular endothelial cell response to Candida albicans

21 January 2018

1 reference

The early transcriptional response of human granulocytes to infection with Candida albicans is not essential for killing but reflects cellular communications

21 January 2018

1 reference

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

21 January 2018

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Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections

21 January 2018

1 reference

Protection against epithelial damage during Candida albicans infection is mediated by PI3K/Akt and mammalian target of rapamycin signaling

21 January 2018

1 reference

Identification by DNA microarray of genes involved in Candida albicans-treated gingival epithelial cells

21 January 2018

1 reference

Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.

21 January 2018

1 reference

Biogeography and individuality shape function in the human skin metagenome

21 January 2018

1 reference

A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology

21 January 2018

1 reference

Topographic diversity of fungal and bacterial communities in human skin

21 January 2018

1 reference

The emerging world of the fungal microbiome

21 January 2018

1 reference

Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis

21 January 2018

1 reference

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22.

21 January 2018

1 reference

Regulation of Candida albicans morphogenesis by fatty acid metabolites

21 January 2018

1 reference

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

21 January 2018

1 reference

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

21 January 2018

1 reference

The cross-talk between opportunistic fungi and the mammalian host via microbiota's metabolism

21 January 2018

1 reference

The bacteriome-mycobiome interaction and antifungal host defense

21 January 2018

1 reference

The potential impact of the pulmonary microbiome on immunopathogenesis of Aspergillus-related lung disease

21 January 2018

1 reference

Trained immunity: a memory for innate host defense

21 January 2018

1 reference

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.

21 January 2018

1 reference

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

21 January 2018

1 reference

Defective trained immunity in patients with STAT-1-dependent chronic mucocutaneaous candidiasis.

21 January 2018

1 reference

Trained innate immunity as a mechanistic link between sepsis and atherosclerosis

21 January 2018

1 reference

A small jab - a big effect: nonspecific immunomodulation by vaccines

21 January 2018

1 reference

β-Glucans and their applications in cancer therapy: focus on human studies.

21 January 2018

1 reference

Human dendritic cells are less potent at killing Candida albicans than both monocytes and macrophages

21 January 2018

1 reference

21 January 2018

1 reference

Regulation of chitin synthesis during dimorphic growth of Candida albicans

21 January 2018

1 reference

The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity

31 March 2020

1 reference

Candida albicans morphogenesis and host defence: discriminating invasion from colonization.

31 March 2020

1 reference

Secreted aspartic proteases of Candida albicansactivate the NLRP3 inflammasome

31 March 2020

1 reference

The classical CD14⁺⁺ CD16⁻ monocytes, but not the patrolling CD14⁺ CD16⁺ monocytes, promote Th17 responses to Candida albicans

31 March 2020

1 reference

Risk factors and predictors of outcome in patients with cancer and breakthrough candidemia

31 March 2020

1 reference

Recognition of yeast nucleic acids triggers a host-protective type I interferon response

31 March 2020

1 reference

Differential role of IL-18 and IL-12 in the host defense against disseminated Candida albicans infection

31 March 2020

1 reference

Recombinant interferon-gamma enhances resistance to acute disseminated Candida albicans infection in mice

31 March 2020

1 reference

Differential effects of IL-17 pathway in disseminated candidiasis and zymosan-induced multiple organ failure

31 March 2020

1 reference

Increased resistance to systemic candidiasis in athymic or interleukin-10-depleted mice

31 March 2020

1 reference

Complement plays a central role in Candida albicans-induced cytokine production by human PBMCs

31 March 2020

1 reference

Therapeutic potential of antiidiotypic single chain antibodies with yeast killer toxin activity

31 March 2020

1 reference

A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine

31 March 2020

1 reference

Skin microbiome imbalance in patients with STAT1/STAT3 defects impairs innate host defense responses

31 March 2020

1 reference

Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes

31 March 2020

1 reference

Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis.

31 March 2020

1 reference

12 December 2020

Evidence for macrophage-mediated protection against lethal Candida albicans infection.

1 reference

12 December 2020

Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling

1 reference

12 December 2020

Kinetic studies of Candida parapsilosis phagocytosis by macrophages and detection of intracellular survival mechanisms

1 reference

12 December 2020

Natural killer cells do not play a dominant role in CD4+ subset differentiation in Candida albicans-infected mice

1 reference

12 December 2020

Coaggregation of Streptococcus sanguis and other streptococci with Candida albicans.

1 reference

12 December 2020

Idiotypic intravaginal vaccination to protect against candidal vaginitis by secretory, yeast killer toxin-like anti-idiotypic antibodies

1 reference

12 December 2020

Blood gene expression signatures predict invasive candidiasis.

1 reference

12 December 2020

Ecology of Candida albicans gut colonization: inhibition of Candida adhesion, colonization, and dissemination from the gastrointestinal tract by bacterial antagonism

1 reference

12 December 2020

Early resistance of interleukin-10 knockout mice to acute systemic candidiasis

1 reference

12 December 2020

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors

1 reference

12 December 2020

Measurement of candidacidal activity of specific leukocyte types in mixed cell populations I. Normal, myeloperoxidase-deficient, and chronic granulomatous disease neutrophils

1 reference

12 December 2020

Proteolytic activation of the interleukin-1beta precursor by Candida albicans.

1 reference

12 December 2020

Role of granulocytes in increased host resistance to Candida albicans induced by recombinant interleukin-1

1 reference

12 December 2020

Immunomodulation by a low-virulence, agerminative variant of Candida albicans. Further evidence for macrophage activation as one of the effector mechanisms of nonspecific anti-infectious protection.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI3897

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4 September 2017

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