(Q38615376)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26497522%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Structural analysis of Fc/FcγR complexes: a blueprint for antibody design (English)

1 reference

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28 February 2020

1

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28 February 2020

Masato Kiyoshi

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26497522%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

author name string

Kouhei Tsumoto

series ordinal

3

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28 February 2020

publication date

1 November 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26497522%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

published in

Immunological Reviews

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26497522%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

volume

268

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26497522%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

issue

1

1 reference

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28 February 2020

page(s)

201-221

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Properties of antibodies cytophilic for macrophages

28 February 2020

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Immune complexes regulate bone metabolism through FcRγ signalling

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CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation

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IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB.

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The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy

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Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV.

21 January 2018

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Experimental Antibody Therapy of Liver Metastases Reveals Functional Redundancy between Fc RI and Fc RIV

21 January 2018

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The importance of human FcgammaRI in mediating protection to malaria

21 January 2018

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FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

21 January 2018

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Interaction sites on human IgG-Fc for FcgammaR: current models

21 January 2018

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Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa

21 January 2018

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Structural Basis for Fc RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes

21 January 2018

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Alteration of the Fc gamma RIIa dimer interface affects receptor signaling but not ligand binding.

21 January 2018

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Inhibition of destructive autoimmune arthritis in FcgammaRIIa transgenic mice by small chemical entities

21 January 2018

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The glycosyl phosphatidylinositol-linked Fc gamma RIIIPMN mediates transmembrane signaling events distinct from Fc gamma RII.

21 January 2018

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Function of human Fc gamma RIIA and Fc gamma RIIIB.

21 January 2018

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Structural basis of the interaction between IgG and fcγ receptors

21 January 2018

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Mapping and comparison of the interaction sites on the Fc region of IgG responsible for triggering antibody dependent cellular cytotoxicity (ADCC) through different types of human Fc gamma receptor

21 January 2018

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The structural requirements for complement activation by IgG: does it hinge on the hinge?

21 January 2018

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Structural recognition and functional activation of FcγR by innate pentraxins

21 January 2018

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Pentraxins and Fc receptors

21 January 2018

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Effective expression of soluble aglycosylated recombinant human Fcγ receptor I by low translational efficiency in Escherichia coli.

21 January 2018

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Localization of the binding site for the human high-affinity Fc receptor on IgG.

21 January 2018

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Crystal Structure of Fc Receptor I and Its Implication in High Affinity -Immunoglobulin Binding

21 January 2018

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Molecular basis for immune complex recognition: a comparison of Fc-receptor structures

21 January 2018

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The binding of soluble recombinant human Fcγ receptor I for human immunoglobulin G is conferred by its first and second extracellular domains

21 January 2018

1 reference

Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI.

21 January 2018

1 reference

Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding.

21 January 2018

1 reference

Structural mechanism of high affinity FcγRI recognition of immunoglobulin G.

21 January 2018

1 reference

Engineering of recombinant human Fcγ receptor I by directed evolution.

21 January 2018

1 reference

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

21 January 2018

1 reference

Shape complementarity at protein/protein interfaces

21 January 2018

1 reference

Characterization of an FcgammaRI-binding peptide selected by phage display

21 January 2018

1 reference

Identification of cyclic peptides able to mimic the functional epitope of IgG1-Fc for human Fc gammaRI.

21 January 2018

1 reference

Fucose depletion from human IgG1 oligosaccharide enhances binding enthalpy and association rate between IgG1 and FcgammaRIIIa

21 January 2018

1 reference

Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

21 January 2018

1 reference

The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity

21 January 2018

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Fucose removal from complex-type oligosaccharide enhances the antibody-dependent cellular cytotoxicity of single-gene-encoded antibody comprising a single-chain antibody linked the antibody constant region

21 January 2018

1 reference

The carbohydrate at FcgammaRIIIa Asn-162. An element required for high affinity binding to non-fucosylated IgG glycoforms

21 January 2018

1 reference

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

21 January 2018

1 reference

Structural comparison of fucosylated and nonfucosylated Fc fragments of human immunoglobulin G1

21 January 2018

1 reference

Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans

21 January 2018

1 reference

Stoichiometry and thermodynamics of the interaction between the Fc fragment of human IgG1 and its low-affinity receptor Fc gamma RIII.

21 January 2018

1 reference

The Human Low Affinity Fcγ Receptors IIa, IIb, and III Bind IgG with Fast Kinetics and Distinct Thermodynamic Properties

21 January 2018

1 reference

Generation of a high-affinity Fcgamma receptor by Ig-domain swapping between human CD64A and CD16A.

21 January 2018

1 reference

Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc

21 January 2018

1 reference

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

21 January 2018

1 reference

Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)

21 January 2018

1 reference

Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity

21 January 2018

1 reference

Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function

21 January 2018

1 reference

TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved

21 January 2018

1 reference

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

21 January 2018

1 reference

3D Structural Fluctuation of IgG1 Antibody Revealed by Individual Particle Electron Tomography.

21 January 2018

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The solution structures of two human IgG1 antibodies show conformational stability and accommodate their C1q and FcγR ligands.

21 January 2018

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Cleavage of the interchain disulfide bonds in rituximab increases its affinity for FcγRIIIA.

21 January 2018

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Immunoglobulin G1 Fc Domain Motions: Implications for Fc Engineering

21 January 2018

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A perspective on the structure and receptor binding properties of immunoglobulin G Fc

21 January 2018

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Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

21 January 2018

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The impact of glycosylation on the biological function and structure of human immunoglobulins.

21 January 2018

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Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis

21 January 2018

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A protein structural change in aglycosylated IgG3 correlates with loss of huFc gamma R1 and huFc gamma R111 binding and/or activation

21 January 2018

1 reference

Recognition of immunoglobulins by Fcgamma receptors

21 January 2018

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Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors

21 January 2018

1 reference

Role of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb binding

21 January 2018

1 reference

Glycoform-dependent conformational alteration of the Fc region of human immunoglobulin G1 as revealed by NMR spectroscopy.

21 January 2018

1 reference

Revisiting the role of glycosylation in the structure of human IgG Fc.

21 January 2018

1 reference

Selective Deactivation of Serum IgG: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions

21 January 2018

1 reference

Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity

21 January 2018

1 reference

Structural Determinants of Unique Properties of Human IgG4-Fc

21 January 2018

1 reference

Crystal structure of deglycosylated human IgG4-Fc

21 January 2018

1 reference

NMR analysis demonstrates immunoglobulin G N-glycans are accessible and dynamic

21 January 2018

1 reference

Intramolecular N-glycan/polypeptide interactions observed at multiple N-glycan remodeling steps through [(13)C,(15)N]-N-acetylglucosamine labeling of immunoglobulin G1.

21 January 2018

1 reference

Variations in oligosaccharide-protein interactions in immunoglobulin G determine the site-specific glycosylation profiles and modulate the dynamic motion of the Fc oligosaccharides

21 January 2018

1 reference

Restricted motion of the conserved immunoglobulin G1 N-glycan is essential for efficient FcγRIIIa binding

21 January 2018

1 reference

Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

21 January 2018

1 reference

Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs

21 January 2018

1 reference

Intravenous immunoglobulin therapy: how does IgG modulate the immune system?

21 January 2018

1 reference

Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc.

21 January 2018

1 reference

General mechanism for modulating immunoglobulin effector function

21 January 2018

1 reference

Crystal structure of sialylated IgG Fc: Implications for the mechanism of intravenous immunoglobulin therapy

21 January 2018

1 reference

Structural Characterization of Anti-Inflammatory Immunoglobulin G Fc Proteins

21 January 2018

1 reference

Engineering Hydrophobic Protein–Carbohydrate Interactions to Fine-Tune Monoclonal Antibodies

21 January 2018

1 reference

Molecular engineering and design of therapeutic antibodies

21 January 2018

1 reference

Engineered therapeutic antibodies with improved effector functions

21 January 2018

1 reference

Engineered antibody Fc variants with enhanced effector function

21 January 2018

1 reference

Structural characterization of a mutated, ADCC-enhanced human Fc fragment

21 January 2018

1 reference

Enhancing the potency of therapeutic monoclonal antibodies via Fc optimization

21 January 2018

1 reference

Asymmetrical Fc engineering greatly enhances antibody-dependent cellular cytotoxicity (ADCC) effector function and stability of the modified antibodies

21 January 2018

1 reference

Novel asymmetrically engineered antibody Fc variant with superior FcγR binding affinity and specificity compared with afucosylated Fc variant

21 January 2018

1 reference

Structural characterization of a human Fc fragment engineered for lack of effector functions

21 January 2018

1 reference

IgG2 Fc structure and the dynamic features of the IgG CH2-CH3 interface

21 January 2018

1 reference

An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations

21 January 2018

1 reference

Emerging principles for the therapeutic exploitation of glycosylation.

21 January 2018

1 reference

Glycosylation as a strategy to improve antibody-based therapeutics

21 January 2018

1 reference

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

21 January 2018

1 reference

Evolution of anti-CD20 monoclonal antibody therapeutics in oncology

21 January 2018

1 reference

Anti-CD20 monoclonal antibodies: historical and future perspectives

21 January 2018

1 reference

Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

21 January 2018

1 reference

Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

21 January 2018

1 reference

Obinutuzumab plus Chlorambucil in Patients with CLL and Coexisting Conditions

21 January 2018

1 reference

Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies

21 January 2018

1 reference

Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution

21 January 2018

1 reference

Engineered antibody Fc variant with selectively enhanced Fc RIIb binding over both Fc RIIaR131 and Fc RIIaH131

21 January 2018

1 reference

Crystal structure of a novel asymmetrically engineered Fc variant with improved affinity for FcγRs

21 January 2018

1 reference

The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex

21 January 2018

1 reference

Crystal structure of the extracellular domain of a human Fc gamma RIII

21 January 2018

1 reference

The structure of a human type III Fcgamma receptor in complex with Fc

21 January 2018

1 reference

Crystal structure of the human high-affinity IgE receptor

21 January 2018

1 reference

Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha

21 January 2018

1 reference

The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms

21 January 2018

1 reference

Convergent recognition of the IgE binding site on the high-affinity IgE receptor

21 January 2018

1 reference

Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.

21 January 2018

1 reference

Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc

21 January 2018

1 reference

Crystal structure of the ectodomain of human FcalphaRI

21 January 2018

1 reference

UniProt: a hub for protein information

21 January 2018

1 reference

Inference of macromolecular assemblies from crystalline state

21 January 2018

1 reference

Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/IMR.12365

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26497522%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference