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Role of Gag in HIV Resistance to Protease Inhibitors
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Europe PubMed Central
PMC publication ID
3185719
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21994687%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
title
Role of Gag in HIV Resistance to Protease Inhibitors
(English)
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Europe PubMed Central
PMC publication ID
3185719
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21994687%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
main subject
HIV resistance to protease inhibitors
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author
Fabrizio Mammano
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2
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Europe PubMed Central
PMC publication ID
3185719
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21994687%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
François Clavel
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François Clavel
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Europe PubMed Central
PMC publication ID
3185719
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21994687%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
publication date
5 July 2010
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Europe PubMed Central
PMC publication ID
3185719
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21994687%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
published in
Viruses
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PMC publication ID
3185719
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21994687%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
volume
2
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Europe PubMed Central
PMC publication ID
3185719
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21994687%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
issue
7
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Europe PubMed Central
PMC publication ID
3185719
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21994687%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
page(s)
1411-1426
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Europe PubMed Central
PMC publication ID
3185719
reference URL
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14 February 2020
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Creative Commons Attribution 4.0 International
start time
5 July 2010
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0 references
cites work
Positive selection pressure introduces secondary mutations at Gag cleavage sites in human immunodeficiency virus type 1 harboring major protease resistance mutations
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Gag mutations strongly contribute to HIV-1 resistance to protease inhibitors in highly drug-experienced patients besides compensating for fitness loss
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6 September 2017
Structural Analysis of Human Immunodeficiency Virus Type 1 CRF01_AE Protease in Complex with the Substrate p1-p6
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6 September 2017
Mutational analysis of the C-terminal gag cleavage sites in human immunodeficiency virus type 1
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PubMed Central
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6 September 2017
A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism
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PubMed Central
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Functional correlation between a novel amino acid insertion at codon 19 in the protease of human immunodeficiency virus type 1 and polymorphism in the p1/p6 Gag cleavage site in drug resistance and replication fitness
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6 September 2017
Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease
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Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate
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Processing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different rates
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PubMed Central
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6 September 2017
Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease
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6 September 2017
Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity
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Gag non-cleavage site mutations contribute to full recovery of viral fitness in protease inhibitor-resistant human immunodeficiency virus type 1.
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6 September 2017
Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease
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6 September 2017
Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes
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PubMed Central
reference URL
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6 September 2017
Proteolytic processing of the p2/nucleocapsid cleavage site is critical for human immunodeficiency virus type 1 RNA dimer maturation.
1 reference
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PubMed Central
reference URL
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Individual contributions of mutant protease and reverse transcriptase to viral infectivity, replication, and protein maturation of antiretroviral drug-resistant human immunodeficiency virus type 1.
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Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites
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PubMed Central
reference URL
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Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor
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Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors
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PubMed Central
reference URL
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6 September 2017
Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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6 September 2017
Effects of human immunodeficiency virus type 1 resistance to protease inhibitors on reverse transcriptase processing, activity, and drug sensitivity.
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PubMed Central
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6 September 2017
Changes in the human immunodeficiency virus p7-p1-p6 gag gene in drug-naive and pretreated patients
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Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults
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PubMed Central
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14 September 2017
Changes in human immunodeficiency virus type 1 Gag at positions L449 and P453 are linked to I50V protease mutants in vivo and cause reduction of sensitivity to amprenavir and improved viral fitness in vitro
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PubMed Central
reference URL
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14 September 2017
Human immunodeficiency virus type 1 protease cleavage site mutations associated with protease inhibitor cross-resistance selected by indinavir, ritonavir, and/or saquinavir
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PubMed Central
reference URL
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14 September 2017
Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug
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14 September 2017
Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients
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14 September 2017
Novel Gag-Pol frameshift site in human immunodeficiency virus type 1 variants resistant to protease inhibitors
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14 September 2017
Loss of viral fitness associated with multiple Gag and Gag-Pol processing defects in human immunodeficiency virus type 1 variants selected for resistance to protease inhibitors in vivo.
1 reference
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PubMed Central
reference URL
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14 September 2017
Variability at human immunodeficiency virus type 1 subtype C protease cleavage sites: an indication of viral fitness?
1 reference
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PubMed Central
reference URL
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14 September 2017
The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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14 September 2017
The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and viral infectivity
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PubMed Central
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14 September 2017
Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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25 September 2017
Association of Gag cleavage sites to protease mutations and to virological response in HIV-1 treated patients.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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23 June 2018
Ordered processing of the human immunodeficiency virus type 1 GagPol precursor is influenced by the context of the embedded viral protease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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23 June 2018
A conformational switch controlling HIV-1 morphogenesis
1 reference
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PubMed Central
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23 June 2018
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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23 June 2018
Peptide substrates and inhibitors of the HIV-1 protease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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23 June 2018
Evolution of protease inhibitor resistance in the gag and pol genes of HIV subtype G isolates
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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31 August 2018
Gag determinants of fitness and drug susceptibility in protease inhibitor-resistant human immunodeficiency virus type 1.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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31 August 2018
Prevalence of C-terminal gag cleavage site mutations in HIV from therapy-naïve patients.
1 reference
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PubMed Central
reference URL
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31 August 2018
Impact of gag mutations on selection of darunavir resistance mutations in HIV-1 protease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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31 August 2018
Compensatory mutations at the HIV cleavage sites p7/p1 and p1/p6-gag in therapy-naive and therapy-experienced patients.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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31 August 2018
Structure-function analysis of the ribosomal frameshifting signal of two human immunodeficiency virus type 1 isolates with increased resistance to viral protease inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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31 August 2018
Prevalence and clinical implications of insertions in the HIV-1 p6Gag N-terminal region in drug-naive individuals initiating antiretroviral therapy.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
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31 August 2018
Amprenavir-resistant HIV-1 exhibits lopinavir cross-resistance and reduced replication capacity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185719
retrieved
31 August 2018
Polymorphism of HIV type 1 gag p7/p1 and p1/p6 cleavage sites: clinical significance and implications for resistance to protease inhibitors
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21994687
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Lamivudine and indinavir/ritonavir maintenance therapy in highly pretreated HIV-infected patients (Vista ANRS 109)
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21994687
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21994687
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
HIV type 1 protease cleavage site mutations and viral fitness: implications for drug susceptibility phenotyping assays
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21994687
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3390/V2071411
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185719
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21994687%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
PMC publication ID
3185719
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185719
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21994687%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
PubMed publication ID
21994687
1 reference
stated in
Europe PubMed Central
PMC publication ID
3185719
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21994687%20AND%20SRC:MED&resulttype=core&format=json
retrieved
14 February 2020
ResearchGate publication ID
51712018
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