(Q38647812)

5 September 2017

Hippo pathway and protection of genome stability in response to DNA damage (English)

1 reference

5 September 2017

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1 reference

Dafni E Pefani

1

1 reference

PubMed ID

26607675

5 September 2017

Eric O'Neill

series ordinal

2

1 reference

PubMed ID

26607675

5 September 2017

language of work or name

English

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publication date

25 November 2015

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5 September 2017

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5 September 2017

283

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5 September 2017

8

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5 September 2017

1392-1403

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

5 September 2017

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The Hippo pathway: regulators and regulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Epithelial cell polarity: what flies can teach us about cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Elucidation of a universal size-control mechanism in Drosophila and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The Drosophila RASSF homolog antagonizes the hippo pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Coordinating developmental signaling: novel roles for the Hippo pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

ATM regulates a RASSF1A-dependent DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Physical interaction with Yes-associated protein enhances p73 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Cell death: the significance of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

p73-induced apoptosis: a question of compartments and cooperation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Single nucleotide polymorphism at codon 133 of the RASSF1 gene is preferentially associated with human lung adenocarcinoma risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Interaction between ATM protein and c-Abl in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

ASPP: a new family of oncogenes and tumour suppressor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

MST1 promotes apoptosis through phosphorylation of histone H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Cracking the death code: apoptosis-related histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Phosphorylation of histone H2B at DNA double-strand breaks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Safeguarding genome stability: RASSF1A tumor suppressor regulates BRCA2 at stalled forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The RASSF1A tumor suppressor regulates XPA-mediated DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

SIRT1 regulates UV-induced DNA repair through deacetylating XPA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Mitotic arrest by tumor suppressor RASSF1A is regulated via CHK1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Clinical utility of RASSF1A methylation in human malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

RASSF1A polymorphism in familial breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

RASSF1A and the Taxol Response in Ovarian Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Control of cell proliferation and apoptosis by mob as tumor suppressor, mats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

Merlin neutralizes the inhibitory effect of Mdm2 on p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13604

21 January 2018

Identifiers

DOI

10.1111/FEBS.13604

1 reference

5 September 2017

1 reference

PubMed ID

26607675