(Q38037329)

27 August 2017

title

The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance (English)

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27 August 2017

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Peter Bouwman

1

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27 August 2017

Jos Jonkers

series ordinal

2

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27 August 2017

language of work or name

English

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publication date

1 September 2012

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27 August 2017

published in

Nature Reviews Cancer

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27 August 2017

volume

12

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27 August 2017

issue

9

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27 August 2017

page(s)

587-598

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https://scigraph.springernature.com/pub.10.1038/nrc3342

27 August 2017

exact match

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cites work

The DNA Damage Response: Making It Safe to Play with Knives

1 reference

Principles of ubiquitin and SUMO modifications in DNA repair.

31 March 2020

1 reference

Brca1 controls homology-directed DNA repair

31 March 2020

1 reference

BRCA2 is required for homology-directed repair of chromosomal breaks

31 March 2020

1 reference

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

31 March 2020

1 reference

Identification of the breast cancer susceptibility gene BRCA2

31 March 2020

1 reference

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

31 March 2020

1 reference

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

31 March 2020

1 reference

Mutation of a mutL homolog in hereditary colon cancer

31 March 2020

1 reference

Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications

31 March 2020

1 reference

Platinum resistance: the role of DNA repair pathways

31 March 2020

1 reference

Targeted radiosensitization of cells expressing truncated DNA polymerase {beta}.

31 March 2020

1 reference

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

31 March 2020

1 reference

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

31 March 2020

1 reference

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

31 March 2020

1 reference

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

31 March 2020

1 reference

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

31 March 2020

1 reference

Genetic Interactions in Cancer Progression and Treatment

31 March 2020

1 reference

A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling

31 March 2020

1 reference

A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance

31 March 2020

1 reference

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

31 March 2020

1 reference

Modeling the therapeutic efficacy of p53 restoration in tumors

31 March 2020

1 reference

Restoration of p53 function leads to tumour regression in vivo

31 March 2020

1 reference

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

1 reference

Stage-specific sensitivity to p53 restoration during lung cancer progression.

31 March 2020

1 reference

Selective activation of p53-mediated tumour suppression in high-grade tumours

31 March 2020

1 reference

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

31 March 2020

1 reference

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

31 March 2020

1 reference

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

31 March 2020

1 reference

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

31 March 2020

1 reference

A decade of exploring the cancer epigenome - biological and translational implications

31 March 2020

1 reference

Translating p53 into the clinic.

31 March 2020

1 reference

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

31 March 2020

1 reference

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

31 March 2020

1 reference

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

31 March 2020

1 reference

Chk1 and Chk2 kinases in checkpoint control and cancer

31 March 2020

1 reference

New insights into checkpoint kinase 1 in the DNA damage response signaling network

31 March 2020

1 reference

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

31 March 2020

1 reference

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

31 March 2020

1 reference

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

31 March 2020

1 reference

Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas

31 March 2020

1 reference

Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo

31 March 2020

1 reference

The combined status of ATM and p53 link tumor development with therapeutic response

31 March 2020

1 reference

In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma

31 March 2020

1 reference

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

31 March 2020

1 reference

ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models

31 March 2020

1 reference

Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

31 March 2020

1 reference

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

31 March 2020

1 reference

Targeting base excision repair for chemosensitization

31 March 2020

1 reference

Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy

31 March 2020

1 reference

Error-prone translesion synthesis mediates acquired chemoresistance

31 March 2020

1 reference

Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control

31 March 2020

1 reference

Hdac3 is essential for the maintenance of chromatin structure and genome stability

31 March 2020

1 reference

Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response

31 March 2020

1 reference

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

31 March 2020

1 reference

SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

31 March 2020

1 reference

Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C

31 March 2020

1 reference

Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

31 March 2020

1 reference

SIRT1 deacetylates APE1 and regulates cellular base excision repair

31 March 2020

1 reference

SIRT1 regulates the function of the Nijmegen breakage syndrome protein

31 March 2020

1 reference

Human SIRT6 promotes DNA end resection through CtIP deacetylation

31 March 2020

1 reference

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

31 March 2020

1 reference

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis

31 March 2020

1 reference

Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.

31 March 2020

1 reference

Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage

31 March 2020

1 reference

Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.

31 March 2020

1 reference

Multidrug resistance in cancer: role of ATP-dependent transporters

31 March 2020

1 reference

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

31 March 2020

1 reference

Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator

31 March 2020

1 reference

Resistance to therapy caused by intragenic deletion in BRCA2

31 March 2020

1 reference

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

31 March 2020

1 reference

Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.

31 March 2020

1 reference

Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance

31 March 2020

1 reference

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

31 March 2020

1 reference

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

31 March 2020

1 reference

BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.

31 March 2020

1 reference

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

31 March 2020

1 reference

PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.

31 March 2020

1 reference

PALB2 links BRCA1 and BRCA2 in the DNA-damage response

31 March 2020

1 reference

Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

31 March 2020

1 reference

Spontaneous functional correction of homozygous Fanconi anaemia alleles reveals novel mechanistic basis for reverse mosaicism

31 March 2020

1 reference

The first 30 years of p53: growing ever more complex

31 March 2020

1 reference

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

31 March 2020

1 reference

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

31 March 2020

1 reference

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

31 March 2020

1 reference

Chemosensitivity linked to p73 function

31 March 2020

1 reference

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

31 March 2020

1 reference

Allele-specific tumor spectrum in pten knockin mice

31 March 2020

1 reference

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

31 March 2020

1 reference

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

31 March 2020

1 reference

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

31 March 2020

1 reference

BRCA1 RING function is essential for tumor suppression but dispensable for therapy resistance.

31 March 2020

1 reference

Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.

31 March 2020

1 reference

Identification of BRCA1-IRIS, a BRCA1 locus product

31 March 2020

1 reference

Identification and functional analysis of novel BRCA1 transcripts, including mouse Brca1-Iris and human pseudo-BRCA1

31 March 2020

1 reference

BRCA1-IRIS overexpression promotes cisplatin resistance in ovarian cancer cells

31 March 2020

1 reference

ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer.

31 March 2020

1 reference

Excision repair cross-complementation group 1 polymorphism predicts overall survival in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy.

31 March 2020

1 reference

Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-links

31 March 2020

1 reference

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links

31 March 2020

1 reference

DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy

31 March 2020

1 reference

The potential of exploiting DNA-repair defects for optimizing lung cancer treatment

31 March 2020

1 reference

Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.

31 March 2020

1 reference

Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway

31 March 2020

1 reference

Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells

31 March 2020

1 reference

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

31 March 2020

1 reference

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

31 March 2020

1 reference

A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

31 March 2020

1 reference

Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair

31 March 2020

1 reference

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

31 March 2020

1 reference

Limiting the persistence of a chromosome break diminishes its mutagenic potential

31 March 2020

1 reference

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

31 March 2020

1 reference

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

31 March 2020

1 reference

53BP1, a mediator of the DNA damage checkpoint

31 March 2020

1 reference

Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

31 March 2020

1 reference

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

31 March 2020

1 reference

Hallmarks of 'BRCAness' in sporadic cancers

31 March 2020

1 reference

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

31 March 2020

1 reference

Gene expression profiling predicts clinical outcome of breast cancer

31 March 2020

1 reference

31 March 2020

1 reference

Do predictive signatures really predict response to cancer chemotherapy?

31 March 2020

1 reference

An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients

31 March 2020

1 reference

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

31 March 2020

1 reference

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

31 March 2020

1 reference

Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide

31 March 2020

1 reference

A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer

31 March 2020

1 reference

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model

31 March 2020

1 reference

In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression

31 March 2020

1 reference

Topoisomerase levels determine chemotherapy responsein vitroandin vivo

31 March 2020

1 reference

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair

31 March 2020

1 reference

6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance

31 March 2020

1 reference

A high-throughput pharmaceutical screen identifies compounds with specific toxicity against BRCA2-deficient tumors

31 March 2020

1 reference

Melphalan as a treatment for BRCA-related ovarian carcinoma: can you teach an old drug new tricks?

31 March 2020

1 reference

High-dose chemotherapy for high-risk primary and metastatic breast cancer: is another look warranted?

31 March 2020

1 reference

The resurgence of platinum-based cancer chemotherapy

31 March 2020

1 reference

Drug candidates derailed in case of mistaken identity

31 March 2020

1 reference

Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

31 March 2020

1 reference

Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma

31 March 2020

1 reference

Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations

31 March 2020

1 reference

Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2

31 March 2020

1 reference

Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.

31 March 2020

1 reference

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

31 March 2020

1 reference

A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants.

31 March 2020

1 reference

A cell-free assay for the functional analysis of variants of the mismatch repair protein MLH1.

31 March 2020

1 reference

Molecular classification of breast carcinomas by comparative genomic hybridization: a specific somatic genetic profile for BRCA1 tumors

31 March 2020

1 reference

12 December 2020

Effect of BRCA Mutations on the Length of Survival in Epithelial Ovarian Tumors

1 reference

12 December 2020

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

1 reference

12 December 2020

Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2

1 reference

12 December 2020

Somatic mosaicism in Fanconi anemia: molecular basis and clinical significance

1 reference

12 December 2020

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3342

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Dimensions Publication ID

27 August 2017

1003979939

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