(Q38653884)

5 September 2017

title

Challenges in oral peptide delivery: lessons learnt from the clinic and future prospects (English)

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5 September 2017

Joël Richard

1

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5 September 2017

publication date

1 July 2017

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5 September 2017

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5 September 2017

volume

8

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5 September 2017

issue

8

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5 September 2017

page(s)

663-684

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5 September 2017

cites work

Therapeutic peptides.

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https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Future directions for peptide therapeutics development

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Peptide therapeutics: current status and future directions

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Challenges in the delivery of peptide drugs: an industry perspective.

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Serve the people or close the sale? Profit-driven overuse of injections and infusions in China's market-based healthcare system

21 January 2018

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A survey of children's preferences for influenza vaccine attributes.

21 January 2018

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New horizons--alternative routes for insulin therapy

21 January 2018

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https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Introduction for the special issue on recent advances in drug delivery across tissue barriers

21 January 2018

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https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Lead discovery and optimization strategies for peptide macrocycles

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Formulation strategies to improve oral peptide delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Basics and recent advances in peptide and protein drug delivery

21 January 2018

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https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Lanreotide Depot: An Antineoplastic Treatment of Carcinoid or Neuroendocrine Tumors

21 January 2018

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Mucins in the mucosal barrier to infection.

21 January 2018

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Tight junction modulation and its relationship to drug delivery

21 January 2018

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Tight junctions, from tight intercellular seals to sophisticated protein complexes involved in drug delivery, pathogens interaction and cell proliferation

21 January 2018

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https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Targeted nanoparticles with novel non-peptidic ligands for oral delivery

21 January 2018

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https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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Lead- and drug-like compounds: the rule-of-five revolution

21 January 2018

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Converting peptides into drug leads by lipidation

21 January 2018

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Eudragit: a technology evaluation

21 January 2018

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Miropin, a novel bacterial serpin from the periodontopathogen Tannerella forsythia, inhibits a broad range of proteases by using different peptide bonds within the reactive center loop

21 January 2018

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Prohemostatic therapy: the rise and fall of aprotinin

21 January 2018

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https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Protein and Peptide drug delivery: oral approaches

21 January 2018

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https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan-EDTA conjugates

21 January 2018

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Oral insulin and buccal insulin: a critical reappraisal

21 January 2018

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Mechanistic understanding of oral drug absorption enhancement of cromolyn sodium by an amino acid derivative.

21 January 2018

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A new drug carrier, Nalpha-deoxycholyl-L: -lysyl-methylester, for enhancing insulin absorption in the intestine

21 January 2018

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Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier.

21 January 2018

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S-protected thiolated chitosan: synthesis and in vitro characterization.

21 January 2018

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Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Approaches for enhancing oral bioavailability of peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

A novel strategy for the enhancement of drug absorption using a claudin modulator

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

The effect of chitosan on transcellular and paracellular mechanisms in the intestinal epithelial barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Intestinal permeation enhancers for oral peptide delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Absorption-Enhancing Effects of Bile Salts

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

PCR-DGGE-based study of fecal microbial stability during the long-term chitosan supplementation of humans

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Effectiveness and toxicity screening of various absorption enhancers using Caco-2 cell monolayers.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Oral bioavailability and multiple dose tolerability of an antisense oligonucleotide tablet formulated with sodium caprate

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

In vitro and in vivo evaluation of effects of sodium caprate on enteral peptide absorption and on mucosal morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Investigation of the enhancing mechanism of sodium N-[8-(2-hydroxybenzoyl)amino]caprylate effect on the intestinal permeability of polar molecules utilizing a voltage clamp method

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Pharmacokinetics of oral cyanocobalamin formulated with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC): an open-label, randomized, single-dose, parallel-group study in healthy male subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

A novel suspension formulation enhances intestinal absorption of macromolecules via transient and reversible transport mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Safety and efficacy of oral octreotide in acromegaly: results of a multicenter phase III trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Salmon calcitonin: a review of current and future therapeutic indications

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Evaluation of the efficacy, safety and pharmacokinetic profile of oral recombinant human parathyroid hormone [rhPTH(1-31)NH(2)] in postmenopausal women with osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

The pharmacokinetics of escitalopram after oral and intravenous administration of single and multiple doses to healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Chemical modifications designed to improve peptide stability: incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

The future of peptide-based drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Cell-penetrating cis-gamma-amino-l-proline-derived peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Challenges for the oral delivery of macromolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Improving drug biological effects by encapsulation into polymeric nanocapsules

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Combination therapy via oral co-administration of insulin- and exendin-4-loaded nanoparticles to treat type 2 diabetic rats undergoing OGTT.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Polymeric nanoparticle technologies for oral drug delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Microneedles for drug delivery via the gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

New medical therapies on the horizon: oral octreotide

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Lessons learned from the clinical development of oral peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Oral delivery of macromolecular drugs: Where we are after almost 100years of attempts.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

Colonic absorption of salmon calcitonin using tetradecyl maltoside (TDM) as a permeation enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FTDE-2017-0024

21 January 2018

Identifiers

DOI

10.4155/TDE-2017-0024

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5 September 2017

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