(Q38667977)

5 September 2017

title

STAT3-Interacting Proteins as Modulators of Transcription Factor Function: Implications to Targeted Cancer Therapy (English)

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5 September 2017

Jennifer E Yeh

1

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5 September 2017

David A Frank

series ordinal

2

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5 September 2017

publication date

10 December 2015

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5 September 2017

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5 September 2017

volume

11

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5 September 2017

issue

8

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5 September 2017

page(s)

795-801

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https://api.crossref.org/works/10.1002%2FCMDC.201500482

5 September 2017

1 reference

Targeting the interleukin-6/Jak/stat pathway in human malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Therapeutic modulators of STAT signalling for human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Jaks and STATs: biological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

GRIM-19-mediated translocation of STAT3 to mitochondria is necessary for TNF-induced necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Function of mitochondrial Stat3 in cellular respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Mechanisms of unphosphorylated STAT3 transcription factor binding to DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Mild oxidative stress induces S-glutathionylation of STAT3 and enhances chemosensitivity of tumoural cells to chemotherapeutic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

S-Glutathionylation at Cys328 and Cys542 impairs STAT3 phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

STAT3-stathmin interactions control microtubule dynamics in migrating T-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Microtubule-Targeted Chemotherapeutic Agents Inhibit Signal Transducer and Activator of Transcription 3 (STAT3) Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

STAT3 inhibitors for cancer therapy: Have all roads been explored?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

STAT inhibitors for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Oncogenic protein interfaces: small molecules, big challenges.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Targeting STAT5 in hematologic malignancies through inhibition of the bromodomain and extra-terminal (BET) bromodomain protein BRD2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

A Stat3-interacting protein (StIP1) regulates cytokine signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Crif1 is a novel transcriptional coactivator of STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

4-Phenylbutyrate stimulates Hsp70 expression through the Elp2 component of elongator and STAT-3 in cystic fibrosis epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Vulnerabilities of mutant SWI/SNF complexes in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Selective inhibition of BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-κB to IL-6 signaling axis and STAT3-driven cancer phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

21 January 2018

Inflammation and cancer

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Triple-Negative Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Progranulin (GP88) tumor tissue expression is associated with increased risk of recurrence in breast cancer patients diagnosed with estrogen receptor positive invasive ductal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Progress towards the development of SH2 domain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Functional importance of Stat3 tetramerization in activation of the alpha 2-macroglobulin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

A chemical biology approach to developing STAT inhibitors: molecular strategies for accelerating clinical translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

STAT3 inhibitor stattic enhances radiosensitivity in esophageal squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Computational study on mechanism of G-quartet oligonucleotide T40214 selectively targeting Stat3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Effective down-regulation of signal transducer and activator of transcription 3 (STAT3) by polyplexes of siRNA and lipid-substituted polyethyleneimine for sensitization of breast tumor cells to conventional chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

STAT3 suppresses transcription of proapoptotic genes in cancer cells with the involvement of its N-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

7 January 2021

Targeting STAT3 in cancer: how successful are we?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

7 January 2021

A STAT3 Gene Expression Signature in Gliomas is Associated with a Poor Prognosis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

7 January 2021

Plasma pyrimethamine concentrations during long-term treatment for cerebral toxoplasmosis in patients with AIDS

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500482

7 January 2021

Identifiers

DOI

10.1002/CMDC.201500482

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5 September 2017

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