(Q38673432)

English

Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

scientific article published on 22 June 2011

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5 February 2020

Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) (English)

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5 February 2020

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based on heuristic

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based on heuristic

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5 February 2020

Costas Koumenis

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5 February 2020

Stephen M. Hahn

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Stephen M Hahn

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5 February 2020

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Xiaobing Tian

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5 February 2020

Michelle Alonso-Basanta

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5 February 2020

Jay F Dorsey

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5 February 2020

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22 June 2011

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5 February 2020

Journal of Biological Chemistry

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5 February 2020

286

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5 February 2020

33

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5 February 2020

29408-29416

1 reference

Europe PubMed Central

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5 February 2020

Regulation of autophagy by ATF4 in response to severe hypoxia.

1 reference

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The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

1 reference

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6 September 2017

ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis.

1 reference

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1 reference

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6 September 2017

The TRAIL apoptotic pathway in cancer onset, progression and therapy

1 reference

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6 September 2017

Malignant gliomas in adults

1 reference

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6 September 2017

Modulation of death receptors by cancer therapeutic agents

1 reference

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6 September 2017

HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress.

1 reference

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6 September 2017

Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo

1 reference

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6 September 2017

Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190746

6 September 2017

The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response

1 reference

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6 September 2017

Apoptosis in gliomas: molecular mechanisms and therapeutic implications

1 reference

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6 September 2017

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190746

6 September 2017

Development of novel targeted therapies in the treatment of malignant glioma

1 reference

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6 September 2017

Death receptor-induced cell killing

1 reference

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6 September 2017

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

1 reference

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Safety and antitumor activity of recombinant soluble Apo2 ligand

1 reference

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Death receptors: signaling and modulation

1 reference

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6 September 2017

APO2 ligand: a novel lethal weapon against malignant glioma?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190746

6 September 2017

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190746

6 September 2017

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190746

6 September 2017

Inhibitors of the biosynthesis and processing of N-linked oligosaccharide chains

1 reference

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14 September 2017

Nelfinavir induces the unfolded protein response in ovarian cancer cells, resulting in ER vacuolization, cell cycle retardation and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190746

14 September 2017

Nelfinavir induces TRAIL receptor upregulation in ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190746

14 September 2017

Upregulation of DR5 by proteasome inhibitors potently sensitizes glioma cells to TRAIL-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190746

14 September 2017

Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190746

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HIV protease inhibitor nelfinavir inhibits growth of human melanoma cells by induction of cell cycle arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190746

14 September 2017

Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy

1 reference

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14 September 2017

Genomic alterations in human malignant glioma cells associate with the cell resistance to the combination treatment with tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy

1 reference

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Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells

1 reference

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14 September 2017

Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein

1 reference

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c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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31 August 2018

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21697087

12 December 2020

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10.1074/JBC.M110.197665

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5 February 2020

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Europe PubMed Central

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5 February 2020

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5 February 2020

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