(Q38675000)

English

Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate

scientific article published on 03 August 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate (English)

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

cholestanol 7alpha,8alpha-epoxide

1 reference

ChEBI release 2020-05-28

7-oxo-5alpha-cholestan-3beta-ol

1 reference

ChEBI release 2020-05-28

F. Peter Guengerich

6

object named as

F Peter Guengerich

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

author name string

Raku Shinkyo

1

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

Libin Xu

2

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

Keri A Tallman

3

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

Qian Cheng

4

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

Ned A Porter

5

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

language of work or name

0 references

publication date

3 August 2011

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

286

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

38

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

33021-33028

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

Inhibition of human cytochrome P450 3A4 by cholesterol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Malformation syndromes caused by disorders of cholesterol synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Oxysterols from free radical chain oxidation of 7-dehydrocholesterol: product and mechanistic studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Rate constants for peroxidation of polyunsaturated fatty acids and sterols in solution and in liposomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Photodamage generates 7-keto- and 7-hydroxycholesterol in the rat retina via a free radical-mediated mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Oxysterols and neurodegenerative diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Cholesterol, reactive oxygen species, and the formation of biologically active mediators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Oxysterols: novel biologic roles for the 21st century

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Reduction of cytochrome b5 by NADPH-cytochrome P450 reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

The Smith-Lemli-Opitz syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Oxysterols: modulators of cholesterol metabolism and other processes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Diagnosis of Smith-Lemli-Opitz syndrome by gas chromatography/mass spectrometry of 7-dehydrocholesterol in plasma, amniotic fluid and cultured skin fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Hydroxylation-induced migration: the NIH shift. Recent experiments reveal an unexpected and general result of enzymatic hydroxylation of aromatic compounds

1 reference

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6 September 2017

Aging decreases the capacity of human skin to produce vitamin D3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Biological activities of oxysterols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Photometabolism of 7-dehydrocholesterol to previtamin D3 in skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

6 September 2017

Cholesterol autoxidation 1981-1986.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

14 September 2017

Steroid metabolism in primates. XVI. Secretion of corticosteroids in the baboon Papio hamadryas during chronic administration of sodium chloride

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

14 September 2017

Metabolism of 4 beta -hydroxycholesterol in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

25 September 2017

Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

25 September 2017

Regulation of steroid hydroxylase gene expression: importance to physiology and disease

1 reference

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25 September 2017

Reconstitution premixes for assays using purified recombinant human cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

23 June 2018

Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

23 June 2018

Oxidation of trichloroethylene by liver microsomal cytochrome P-450: evidence for chlorine migration in a transition state not involving trichloroethylene oxide

1 reference

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23 June 2018

Oxidation of monosubstituted olefins by cytochromes P-450 and heme models: evidence for the formation of aldehydes in addition to epoxides and allylic alcohols

1 reference

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23 June 2018

Olefin oxidation by cytochrome P-450: evidence for group migration in catalytic intermediates formed with vinylidene chloride and trans-1-phenyl-1-butene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

23 June 2018

Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

31 August 2018

A simple and rapid method to measure cholesterol binding to P450s and other proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

31 August 2018

Purification and characterization of hamster liver microsomal 7alpha-hydroxycholesterol dehydrogenase. Similarity to type I 11beta-hydroxysteroid dehydrogenase

1 reference

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31 August 2018

Drug metabolism by Escherichia coli expressing human cytochromes P450.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

31 August 2018

Cholesterol 7 alpha-hydroxylase is up-regulated by the competitive inhibitor 7-oxocholesterol in rat liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

31 August 2018

Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

31 August 2018

Markedly increased tissue concentrations of 7-dehydrocholesterol combined with low levels of cholesterol are characteristic of the Smith-Lemli-Opitz syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3190903

31 August 2018

Elucidation of distinct ligand binding sites for cytochrome P450 3A4

1 reference

https://pubmed.ncbi.nlm.nih.gov/21813643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and inhibition of growth of human fibroblasts by 7-ketocholesterol

1 reference

https://pubmed.ncbi.nlm.nih.gov/21813643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay of unesterified 7-oxocholesterol in human serum by isotope dilution-mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/21813643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous quantification of several cholesterol autoxidation and monohydroxylation products by isotope-dilution mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/21813643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The urinary bile acid excretion in healthy premature and full-term infants during the neonatal period

1 reference

https://pubmed.ncbi.nlm.nih.gov/21813643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol

1 reference

https://pubmed.ncbi.nlm.nih.gov/21813643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/21813643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of cholesterol oxidation products formed by oxidative modification of low density lipoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/21813643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

7-Hydroperoxycholesterol and its products in oxidized low density lipoprotein and human atherosclerotic plaque

1 reference

https://pubmed.ncbi.nlm.nih.gov/21813643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the alanine at position 363 of cytochrome P450 2B2 in influencing the NADPH- and hydroperoxide-supported activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/21813643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxysterols and atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21813643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of cholesterol and simvastatin treatment in patients with Smith-Lemli-Opitz syndrome (SLOS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21813643

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.282434

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

5 September 2017

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