(Q38675004)

5 September 2017

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title

Covalent and noncovalent protein binding of drugs: implications for hepatic clearance, storage, and cell-specific drug delivery (English)

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5 September 2017

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D K Meijer

1

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5 September 2017

P van der Sluijs

series ordinal

2

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5 September 2017

publication date

1 February 1989

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5 September 2017

published in

Pharmaceutical Research

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5 September 2017

volume

6

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5 September 2017

issue

2

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5 September 2017

page(s)

105-118

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Biliary excretion of FITC metabolites after administration of FITC labeled asialo orosomucoid as a measure of lysosomal proteolysis

5 September 2017

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12 December 2020

Rapid release of galactose-terminated ligands after endocytosis by hepatic parenchymal cells: evidence for a role of carbohydrate structure in the release of internalized ligand from receptor

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12 December 2020

The Glycosylation of Hemoglobin: Relevance to Diabetes Mellitus

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12 December 2020

Acetaminophen hepatotoxicity and targeted rescue: a model for specific chemotherapy of hepatocellular carcinoma

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12 December 2020

Uptake and distribution of placental glucocerebrosidase in rat hepatic cells and effects of sequential deglycosylation

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12 December 2020

Glycation of skin collagen in type I diabetes mellitus. Correlation with long-term complications

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12 December 2020

Subdivision of hexagonal liver lobules into a structural and functional unit; role in hepatic physiology and pathology

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12 December 2020

Reaction of acetaldehyde with hemoglobin.

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12 December 2020

Receptor for Albumin on the Liver Cell Surface May Mediate Uptake of Fatty Acids and Other Albumin-Bound Substances

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12 December 2020

Regulation of transepithelial H+ transport by exocytosis and endocytosis

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12 December 2020

Functional hepatocellular heterogeneity.

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12 December 2020

Modeling of substrate elimination by the liver: has the albumin receptor model superseded the well-stirred model?

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12 December 2020

Liver endothelium mediates the hepatocyte's uptake of ceruloplasmin

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12 December 2020

Hepatic uptake and biliary excretion of d-tubocurarine and trimethyltubocurarine in the rat in vivo and in isolated perfused rat livers

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12 December 2020

A low-molecular-weight protein from rat liver that resembles ligandin in its binding properties

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12 December 2020

A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro and in vivo studies

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12 December 2020

Drug targeting to the liver with lactosylated albumins: does the glycoprotein target the drug or is the drug targeting the glycoprotein?

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12 December 2020

Localization of d-tubocurarine in rat liver lysosomes. Lysosomal uptake, biliary excretion and displacement by quinacrine in vivo

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12 December 2020

Transport and intracellular localization of cortisol-asialotranscortin complexes in rat liver

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12 December 2020

Galactosylated poly(L-lysine) as a hepatotropic carrier of 9-beta-D-arabinofuranosyladenine 5'-monophosphate

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12 December 2020

Transport of dibromosulphthalein by isolated rat hepatocytes

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12 December 2020

Receptor-Mediated Introduction of Pepstatin-Asialofetuin Conjugate into Lysosomes of Rat Hepatocytes

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12 December 2020

Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites

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12 December 2020

A water-soluble cholesteryl-containing trisgalactoside: synthesis, properties, and use in directing lipid-containing particles to the liver

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12 December 2020

Covalent binding of acetaldehyde selectively inhibits the catalytic activity of lysine-dependent enzymes

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12 December 2020

Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study

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12 December 2020

The role of an albumin receptor in hepatic organic anion uptake: the controversy continues

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12 December 2020

Kinetics of uptake and activity in mouse liver of glutaminase coupled to desialated orosomucoid

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12 December 2020

A receptor-mediated pathway for cholesterol homeostasis

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12 December 2020

Enhanced inhibition of virus DNA synthesis in hepatocytes by trifluorothymidine coupled to asialofetuin

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12 December 2020

Enhancement of Na+-dependent bile acid uptake by albumin: direct demonstration in rat basolateral liver plasma membrane vesicles

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12 December 2020

Binding and endocytosis of cluster glycosides by rabbit hepatocytes. Evidence for a short-circuit pathway that does not lead to degradation.

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12 December 2020

Studies of the mechanism of cell intoxication by diphtheria toxin fragment A-asialoorosomucoid hybrid toxins. Evidence for utilization of an alternative receptor-mediated transport pathway

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12 December 2020

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system

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12 December 2020

Hepatic uptake and biliary excretion of dibromosulphthalein. Albumin dependence, influence of phenobarbital and nafenopin pretreatment and the role of y and z protein

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12 December 2020

Hepatic Recognition and Catabolism of Serum Glycoproteins

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12 December 2020

Role of nonenzymatic glycosylation in atherogenesis

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12 December 2020

Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anions

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12 December 2020

Conformational change in plasma albumin due to interaction with isolated rat hepatocyte

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12 December 2020

A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity

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12 December 2020

Scavenger receptor-mediated recognition of maleyl bovine plasma albumin and the demaleylated protein in human monocyte macrophages

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12 December 2020

Nonenzymatic glucosylation of lysine residues in albumin

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12 December 2020

Kinetic evaluation of carrier-mediated transport of ouabain and taurocholic acid in isolated rat hepatocytes. Evidence for independent transport systems

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12 December 2020

Characterization of the isomeric esters of zomepirac glucuronide by proton NMR.

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12 December 2020

Uptake of iopanoic acid by isolated rat hepatocytes in primary culture

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12 December 2020

Acinar redistribution and heterogeneity in transport of the organic cation rhodamine B in rat liver

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12 December 2020

Kinetic analysis of albumin-mediated uptake of warfarin by perfused rat liver

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12 December 2020

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12 December 2020

On the localisation of d-tubocurarine in rat liver lysosomes in vivo by electron microscopy and subcellular fractionation

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12 December 2020

Endocytosis of asialoglycoprotein-enzyme conjugates by hepatocytes

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12 December 2020

Asialoglycoprotein receptor mediates the toxic effects of an asialofetuin-diphtheria toxin fragment A conjugate on cultured rat hepatocytes

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12 December 2020

Effect of glucagon on hepatic taurocholate uptake: relationship to membrane potential

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12 December 2020

Receptor-mediated endocytosis

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12 December 2020

Current concepts on hepatic transport of drugs

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12 December 2020

The effect of albumin conformation on the binding of warfarin to human serum albumin. The dependence of the binding of warfarin to human serum albumin on the hydrogen, calcium, and chloride ion concentrations as studied by circular dichroism, fluore

1 reference

12 December 2020

Origin of mammalian biliprotein and rearrangement of bilirubin glucuronides in vivo in the rat

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12 December 2020

Novel macrophage receptor for glucose-modified proteins is distinct from previously described scavenger receptors

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12 December 2020

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12 December 2020

Metabolism and transport of amphipathic molecules in analbuminemic rats and human subjects

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12 December 2020

Evidence for targeted gene delivery to Hep G2 hepatoma cells in vitro

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12 December 2020

Metabolism of native and of lactosylated human low density lipoprotein: evidence for two pathways for catabolism of exogenous proteins in rat hepatocytes

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12 December 2020

Acidification of the endocytic and exocytic pathways

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12 December 2020

Lactosylation of albumin reduces uptake rate of dibromosulfophthalein in perfused rat liver and dissociation rate from albumin in vitro

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12 December 2020

Albumin does not mediate the removal of taurocholate by the rat liver

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12 December 2020

Induction and inhibition of pinocytosis by aminoglycoside antibiotics

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12 December 2020

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12 December 2020

Autoradiographic and kinetic demonstration of acinar heterogeneity of taurocholate transport.

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12 December 2020

Carbohydrate-Specific Receptors of the Liver

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12 December 2020

Selective penetration and pharmacological activity of lactosaminated albumin conjugates of adenine arabinoside 5-monophosphate (ara-AMP) in mouse liver

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12 December 2020

Albumin helps mediate removal of taurocholate by rat liver

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12 December 2020

Hepatic uptake of albumin-bound substances: albumin receptor concept

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12 December 2020

Functional and anatomic heterogeneity in the liver acinus: impact on transport

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12 December 2020

Modulation of the circulation and hepatic uptake of immune complexes by carbohydrate recognition systems

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12 December 2020

Mechanisms of bile formation, hepatic uptake, and biliary excretion.

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12 December 2020

Commentary: a physiological approach to hepatic drug clearance

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12 December 2020

In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells

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12 December 2020

Sublobular compartmentation of pharmacologic events (SCOPE): metabolic fluxes in periportal and pericentral regions of the liver lobule

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12 December 2020

The isolation of carcinogen-binding protein from livers of rats given 4-dimethylaminoazobenzene

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12 December 2020

Plasma binding of an alpha-blocking agent, nicergoline--affinity for serum albumin and native and modified alpha 1-acid glycoprotein

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12 December 2020

High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senescent macromolecules

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12 December 2020

Receptor-mediated endocytosis

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12 December 2020

Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis

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12 December 2020

Hepatic drug transport in the rat. A comparison between isolated hepatocytes, the isolated perfused liver and the liver in vivo

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12 December 2020

Selective delivery of cytotoxic compounds to cells by the LDL pathway

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12 December 2020

Receptor-mediated endocytosis and targeted drug delivery

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12 December 2020

Hepatic membrane receptors for glycoproteins

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12 December 2020

Clearance approaches in pharmacology.

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12 December 2020

Irreversible binding of conjugated bilirubin to albumin in cholestatic rats

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12 December 2020

Human serum albumin as a 'silent receptor' for drugs and endogenous substances

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12 December 2020

Binding of sulfobromophthalein (BSP) sodium by plasma albumin. Its role in hepatic BSP extraction

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12 December 2020

Role of ligandin in transfer of bilirubin from plasma into liver

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12 December 2020

Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor

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12 December 2020

Targeting of synthetically glycosylated human placental glucocerebrosidase

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12 December 2020

Rationale for monitoring free drug levels

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12 December 2020

Lumpers vs. distributers

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12 December 2020

The interaction in vivo of transferrin and asialotransferrin with liver cells.

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12 December 2020

Disease-induced changes in the plasma binding of basic drugs

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12 December 2020

Metabolism of quaternary ammonium compounds. I. Binding of tropane alkaloids to rat liver lysosomes

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12 December 2020

Cis-aconityl spacer between daunomycin and macromolecular carriers: A model of pH-sensitive linkage releasing drug from a lysosomotropic conjugate

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12 December 2020

Influence of albumin on the hepatic uptake of unconjugated bilirubin

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12 December 2020

Drug targeting in antiviral chemotherapy. A chemically stable conjugate of 9-beta-D-arabinofuranosyl-adenine 5'-monophosphate with lactosaminated albumin accomplishes a selective delivery of the drug to liver cells

1 reference

12 December 2020

Model for specific rescue of normal hepatocytes during methotrexate treatment of hepatic malignancy

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12 December 2020

Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells

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12 December 2020

Influence of taurocholate on hepatic clearance and biliary excretion of asialo intestinal alkaline phosphatase in the rat in vivo and in isolated perfused rat liver

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12 December 2020

Aging of proteins: isolation and identification of a fluorescent chromophore from the reaction of polypeptides with glucose

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12 December 2020

Proteins in bile: how they get there and what they do.

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12 December 2020

In vivo quantification of receptor-mediated uptake of asialoglycoproteins by rat liver.

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12 December 2020

Protein Binding and Kinetics of Drugs in Liver Diseases

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12 December 2020

Carrier-linked primaquine in the chemotherapy of malaria

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12 December 2020

Killing of cultured hepatocytes by conjugates of asialofetuin and EGF linked to the A chains of ricin or diphtheria toxin

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12 December 2020

Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment

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12 December 2020

Mechanisms of Hepatic Bile Formation

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12 December 2020

Binding properties of glycosylated albumin and acetaldehyde albumin.

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12 December 2020

Pharmacokinetics of the hepatic transport of organic anions: influence of extra- and intracellular binding on hepatic storage of dibromosulfophthalein and interactions with indocyanine green

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12 December 2020

Liver endothelium desialates ceruloplasmin

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12 December 2020

Tc-99m galactosyl-neoglycoalbumin: in vitro characterization of receptor-mediated binding

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12 December 2020

Heterogeneous acinar localization of the asialoglycoprotein internalization system in rat hepatocytes

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12 December 2020

Effect of altered plasma protein binding on pharmacokinetics and pharmacodynamics of propranolol in rats after surgery: role of alpha-1-acid glycoprotein

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12 December 2020

Tc-99m-galactosyl-neoglycoalbumin: in vivo characterization of receptor-mediated binding to hepatocytes

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12 December 2020

Leishmania promastigotes are recognized by the macrophage receptor for advanced glycosylation endproducts

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12 December 2020

Technetium-99m NGA functional hepatic imaging: preliminary clinical experience

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12 December 2020

Conjugates of adenine 9-α-D-arabinofuranoside monophosphate (ara-AMP) with lactosaminated homologous albumin are not immunogenic in the mouse

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12 December 2020

Intracellular receptor sorting during endocytosis: Comparative immunoelectron microscopy of multiple receptors in rat liver

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12 December 2020

Reciprocal Relation between Plasma Albumin Level and Hepatic Sulfobromophthalein Removal

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12 December 2020

Studies of albumin binding to rat liver plasma membranes. Implications for the albumin receptor hypothesis.

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12 December 2020

Uptake of oleate from albumin solutions by rat liver. Failure to detect catalysis of the dissociation of oleate from albumin by an albumin receptor

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12 December 2020

Hepatic disposition of cationic drugs bound to asialoorosomucoid: lack of coendocytosis and evidence for intrahepatic dissociation

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12 December 2020

Dissociation from albumin: a potentially rate-limiting step in the clearance of substances by the liver

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12 December 2020

Hepatic bilirubin uptake in the isolated perfused rat liver is not facilitated by albumin binding

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12 December 2020

Hepatic uptake of proteins coupled to fetuin glycopeptide

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12 December 2020

Function and regulation of hepatic and intestinal fatty acid binding proteins

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12 December 2020

Molecular aspects of ligand binding to serum albumin.

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12 December 2020

Effect of dehydrocholic, chenodeoxycholic, and taurocholic acids on the excretion of bilirubin

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12 December 2020

Nonenzymatic glucosylation of homologous low density lipoprotein and albumin renders them immunogenic in the guinea pig.

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12 December 2020

Irreversible binding of zomepirac to plasma protein in vitro and in vivo

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12 December 2020

Biological approaches to the controlled delivery of drugs: a critical review.

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12 December 2020

Hepatic uptake of propranolol.

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12 December 2020

Role of the carbohydrate moiety in determining the survival of interferon in the circulation

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12 December 2020

Neoglycoproteins: the preparation and application of synthetic glycoproteins.

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12 December 2020

Identifiers

DOI

10.1023/A:1015961424122

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5 September 2017

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