(Q38690898)

17 July 2018

title

Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes (English)

1 reference

17 July 2018

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type 2 diabetes

9 December 2023

21

Ronald M Evans

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Shannon M Reilly

object named as

Shannon M Reilly

2

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author name string

Elif A Oral

1

1 reference

17 July 2018

Andrew V Gomez

3

1 reference

17 July 2018

Rasimcan Meral

4

1 reference

17 July 2018

Laura Butz

5

1 reference

17 July 2018

Nevin Ajluni

6

1 reference

17 July 2018

Thomas L Chenevert

7

1 reference

17 July 2018

Evgenia Korytnaya

8

1 reference

17 July 2018

Adam H Neidert

9

1 reference

17 July 2018

Rita Hench

10

1 reference

17 July 2018

Diana Rus

11

1 reference

17 July 2018

Jeffrey F Horowitz

12

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17 July 2018

BreAnne Poirier

13

1 reference

17 July 2018

Peng Zhao

14

1 reference

17 July 2018

Kim Lehmann

15

1 reference

17 July 2018

Mohit Jain

16

1 reference

17 July 2018

Ruth Yu

17

1 reference

17 July 2018

Christopher Liddle

18

1 reference

17 July 2018

Maryam Ahmadian

19

1 reference

17 July 2018

Michael Downes

20

1 reference

17 July 2018

Alan R Saltiel

22

1 reference

17 July 2018

language of work or name

1 reference

1 July 2017

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17 July 2018

published in

Cell Metabolism

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17 July 2018

volume

26

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17 July 2018

issue

1

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17 July 2018

page(s)

157-170.e7

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17 July 2018

Regulation of metabolism by the innate immune system

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An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

27 July 2018

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27 July 2018

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Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes

27 July 2018

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27 July 2018

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27 July 2018

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The heritability of beta cell function parameters in a mixed meal test design

27 July 2018

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27 July 2018

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Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages

27 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

The protein kinase IKKepsilon regulates energy balance in obese mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

27 July 2018

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Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

27 July 2018

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Multiecho water-fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling

27 July 2018

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27 July 2018

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Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

IKK-beta links inflammation to obesity-induced insulin resistance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Obesity is associated with macrophage accumulation in adipose tissue

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

HCC-2, a human chemokine: gene structure, expression pattern, and biological activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

In vivo resistance of lipolysis to epinephrine. A new feature of childhood onset obesity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Brown adipose tissue, beta 3-adrenergic receptors, and obesity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Multiple lipolysis defects in the insulin resistance (metabolic) syndrome

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Validation of body composition by dual energy X-ray absorptiometry (DEXA).

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Glucose clamp technique: a method for quantifying insulin secretion and resistance

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Spectrum of disease associated with partial lipodystrophy: lessons from a trial cohort

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Homozygous LIPE mutation in siblings with multiple symmetric lipomatosis, partial lipodystrophy, and myopathy.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Visualized macrophage dynamics and significance of S100A8 in obese fat

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

A novel LIPE nonsense mutation found using exome sequencing in siblings with late-onset familial partial lipodystrophy.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Evidence of early alterations in adipose tissue biology and function and its association with obesity-related inflammation and insulin resistance in children

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Clinically relevant reductions in HbA1c without hypoglycaemia: results across four studies of saxagliptin

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Hypoxia and adipose tissue function and dysfunction in obesity.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Inflammation and lipid signaling in the etiology of insulin resistance

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Macrophages, inflammation, and insulin resistance

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Comparison of composite whole body insulin sensitivity index derived from mixed meal test and oral glucose tolerance test in insulin resistant obese subjects

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Pharmacodynamics of Amlexanox (AA-673) in normal and anaphylactic rat conjunctiva and its effect on histamine concentration

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Inhibitory effect of amlexanox on asthmatic attacks in an aspirin sensitive asthmatic

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5663294

Catecholamine-induced lipolysis in obesity

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28683283

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28683283

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28683283

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CMET.2017.06.006

1 reference

17 July 2018

PMC publication ID

5663294

1 reference

17 July 2018

PubMed ID

28683283

1 reference

17 July 2018