(Q38691490)

5 September 2017

title

Formation and removal of poly-ubiquitin chains in the regulation of tumor necrosis factor-induced gene activation and cell death (English)

1 reference

5 September 2017

1 reference

Sebastian Kupka

1

1 reference

5 September 2017

Matthias Reichert

series ordinal

2

1 reference

5 September 2017

Peter Draber

series ordinal

3

1 reference

5 September 2017

Henning Walczak

series ordinal

4

1 reference

5 September 2017

language of work or name

English

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publication date

7 January 2016

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5 September 2017

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5 September 2017

volume

283

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5 September 2017

issue

14

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5 September 2017

page(s)

2626-2639

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Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages.

5 September 2017

cites work

1 reference

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

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No one can whistle a symphony alone - how different ubiquitin linkages cooperate to orchestrate NF-κB activity

21 January 2018

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The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

21 January 2018

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

21 January 2018

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TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

21 January 2018

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The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

21 January 2018

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13644

Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13644

Linear ubiquitination prevents inflammation and regulates immune signalling

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13644

Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13644

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

A ubiquitin ligase complex assembles linear polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Programmed necrosis: backup to and competitor with apoptosis in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Necroptosis: an emerging form of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

TNF-alpha induces two distinct caspase-8 activation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Identification of RIP1 kinase as a specific cellular target of necrostatins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

IAPs, regulators of innate immunity and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

21 January 2018

The FLIP Side of Life

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Survival function of the FADD-CASPASE-8-cFLIP(L) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

IAPs limit activation of RIP kinases by TNF receptor 1 during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Caspase 8 inhibits programmed necrosis by processing CYLD

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

OTULIN restricts Met1-linked ubiquitination to control innate immune signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Negative regulation of JNK signaling by the tumor suppressor CYLD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Identification of the familial cylindromatosis tumour-suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Identification of the cylindromatosis tumor-suppressor gene responsible for multiple familial trichoepithelioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Update of cylindromatosis gene (CYLD) mutations in Brooke-Spiegler syndrome: novel insights into the role of deubiquitination in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Linear ubiquitination in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Structure of the A20 OTU domain and mechanistic insights into deubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Molecular Basis for the Unique Deubiquitinating Activity of the NF-κB Inhibitor A20

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

A20 in inflammation and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

The deubiquitinase activity of A20 is dispensable for NF-κB signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Direct, noncatalytic mechanism of IKK inhibition by A20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

A20 zinc finger protein inhibits TNF-induced apoptosis and stress response early in the signaling cascades and independently of binding to TRAF2 or 14-3-3 proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13644

21 January 2018

Identifiers

DOI

10.1111/FEBS.13644

1 reference

5 September 2017

1 reference