(Q38693793)

5 September 2017

title

Unique marine derived cyanobacterial biosynthetic genes for chemical diversity (English)

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5 September 2017

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1 reference

4

William H Gerwick

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5 September 2017

3

David H Sherman

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5 September 2017

2

Lena Gerwick

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5 September 2017

1

Karin Kleigrewe

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5 September 2017

publication date

13 January 2016

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5 September 2017

published in

Natural Product Reports

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5 September 2017

volume

33

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5 September 2017

issue

2

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5 September 2017

page(s)

348-364

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Lessons from the past and charting the future of marine natural products drug discovery and chemical biology

5 September 2017

cites work

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Reassessing the first appearance of eukaryotes and cyanobacteria

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Cyanobacterial-bacterial mat consortia: examining the functional unit of microbial survival and growth in extreme environments

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Biological targets and mechanisms of action of natural products from marine cyanobacteria

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Cyanobacteria: potential candidates for drug discovery

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One health and cyanobacteria in freshwater systems: animal illnesses and deaths are sentinel events for human health risks

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Mining cyanobacterial genomes for genes encoding complex biosynthetic pathways

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Metamorphic enzyme assembly in polyketide diversification

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Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage

21 January 2018

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Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria.

21 January 2018

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The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria

21 January 2018

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Phylogenetic inferences reveal a large extent of novel biodiversity in chemically rich tropical marine cyanobacteria

21 January 2018

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Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula

21 January 2018

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Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula

21 January 2018

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A functional genomics approach to the mode of action of apratoxin A.

21 January 2018

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Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00097A

Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00097A

Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria

21 January 2018

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Mass spectral molecular networking of living microbial colonies

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00097A

Quantitative molecular networking to profile marine cyanobacterial metabolomes

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00097A

Cylindrocyclophane biosynthesis involves functionalization of an unactivated carbon center

21 January 2018

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Biosynthesis-assisted structural elucidation of the bartolosides, chlorinated aromatic glycolipids from cyanobacteria.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00097A

Crystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic Pathway

21 January 2018

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Lyngbyatoxin biosynthesis: sequence of biosynthetic gene cluster and identification of a novel aromatic prenyltransferase

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00097A

Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly

21 January 2018

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https://api.crossref.org/works/10.1039%2FC5NP00097A

Moorea producens gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Isolation, structure determination, and biological activity of Lyngbyabellin A from the marine cyanobacterium lyngbya majuscula

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Carmabins A and B, new lipopeptides from the Caribbean cyanobacterium Lyngbya majuscula

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

De novo biosynthesis of terminal alkyne-labeled natural products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Insights from the sea: structural biology of marine polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

The structural role of the carrier protein--active controller or passive carrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Characterization of the mupirocin biosynthesis gene cluster from Pseudomonas fluorescens NCIMB 10586.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Characterization of Molecular Interactions between ACP and Halogenase Domains in the Curacin A Polyketide Synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Structural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Cyanobacterial Polyketide Synthase Docking Domains: A Tool for Engineering Natural Product Biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Conformational switch triggered by -ketoglutarate in a halogenase of curacin A biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

A new family of iron-dependent halogenases acts on freestanding substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

The role of chloride in the mechanism of O(2) activation at the mononuclear nonheme Fe(II) center of the halogenase HctB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Structure and activity of DmmA, a marine haloalkane dehalogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Structural Basis of Functional Group Activation by Sulfotransferases in Complex Metabolic Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Modular synthase-encoding gene involved in α-olefin biosynthesis in Synechococcus sp. strain PCC 7002.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis: STRUCTURE OF A DECARBOXYLATING THIOESTERASE

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Microbial Biosynthesis of Alkanes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

The biosynthesis of cyanobacterial sunscreen scytonemin in intertidal microbial mat communities

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Microbial ultraviolet sunscreens

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

A comparative genomics approach to understanding the biosynthesis of the sunscreen scytonemin in cyanobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Probing the in vivo biosynthesis of scytonemin, a cyanobacterial ultraviolet radiation sunscreen, through small scale stable isotope incubation studies and MALDI-TOF mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Organization, evolution, and expression analysis of the biosynthetic gene cluster for scytonemin, a cyanobacterial UV-absorbing pigment

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Mycosporines: are they nature's sunscreens?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

O-Methyltransferase is shared between the pentose phosphate and shikimate pathways and is essential for mycosporine-like amino acid biosynthesis in Anabaena variabilis ATCC 29413.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

The Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Identification and characterization of a welwitindolinone alkaloid biosynthetic gene cluster in the stigonematalean Cyanobacterium Hapalosiphon welwitschii.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Linking chemistry and genetics in the growing cyanobactin natural products family

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

A global assembly line for cyanobactins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Genome mining expands the chemical diversity of the cyanobactin family to include highly modified linear peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Aestuaramides, a natural library of cyanobactin cyclic peptides resulting from isoprene-derived Claisen rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Enzymatic basis of ribosomal peptide prenylation in cyanobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Biosynthesis: Leading the way to RiPPs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Structural analysis of leader peptide binding enables leader-free cyanobactin processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Temporal dynamics of natural product biosynthesis in marine cyanobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Recent approaches for the synthesis of modified cryptophycins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Chemoenzymatic synthesis of cryptophycin/arenastatin natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Efficient, divergent synthesis of cryptophycin unit A analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

antiSMASH 2.0--a versatile platform for genome mining of secondary metabolite producers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Cyanobacterial toxins: biosynthetic routes and evolutionary roots

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Exploring cyanobacterial genomes for natural product biosynthesis pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5NP00097A

21 January 2018

Identifiers

DOI

10.1039/C5NP00097A

1 reference

5 September 2017

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