(Q38704810)

5 September 2017

Antibacterial drug discovery in the resistance era. (English)

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5 September 2017

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Eric D Brown

1

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5 September 2017

Gerard D Wright

series ordinal

2

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5 September 2017

language of work or name

English

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publication date

1 January 2016

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5 September 2017

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5 September 2017

529

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5 September 2017

7586

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5 September 2017

336-343

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https://scigraph.springernature.com/pub.10.1038/nature17042

5 September 2017

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cites work

Challenges of antibacterial discovery

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12 December 2020

Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

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12 December 2020

A structural basis for streptomycin-induced misreading of the genetic code

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12 December 2020

Bioinformatics of antimicrobial resistance in the age of molecular epidemiology

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12 December 2020

The shared antibiotic resistome of soil bacteria and human pathogens

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12 December 2020

The future of antibiotics

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12 December 2020

Network visualization and analysis of gene expression data using BioLayout Express(3D).

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12 December 2020

Discovery of a small molecule that blocks wall teichoic acid biosynthesis in Staphylococcus aureus

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12 December 2020

The antibiotic resistome: the nexus of chemical and genetic diversity

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12 December 2020

The genetic landscape of a cell

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12 December 2020

Bioactive microbial metabolites

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12 December 2020

Mining the microbial dark matter

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12 December 2020

Marcel Faber Roundtable: is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration?

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12 December 2020

Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams.

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12 December 2020

An environmental bacterial taxon with a large and distinct metabolic repertoire

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12 December 2020

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

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12 December 2020

Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions

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12 December 2020

Drugs for bad bugs: confronting the challenges of antibacterial discovery

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12 December 2020

Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production

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12 December 2020

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

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12 December 2020

A genome-wide strategy for the identification of essential genes in Staphylococcus aureus

1 reference

12 December 2020

Non-traditional antibacterial screening approaches for the identification of novel inhibitors of the glyoxylate shunt in gram-negative pathogens

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12 December 2020

Unraveling the physiological complexities of antibiotic lethality.

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12 December 2020

Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery

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12 December 2020

Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents

1 reference

12 December 2020

Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics

1 reference

12 December 2020

The neglected intrinsic resistome of bacterial pathogens

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12 December 2020

Antibiotic resistance is prevalent in an isolated cave microbiome

1 reference

12 December 2020

Pay dirt: the story of streptomycin. Part I. From Waksman to Waksman

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12 December 2020

Systematic discovery of multicomponent therapeutics

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12 December 2020

The soil resistome: a critical review on antibiotic resistance origins, ecology and dissemination potential in telluric bacteria.

1 reference

12 December 2020

Interaction network containing conserved and essential protein complexes in Escherichia coli

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12 December 2020

Prokaryotic toxin-antitoxin stress response loci

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12 December 2020

Identification of anti-virulence compounds that disrupt quorum-sensing regulated acute and persistent pathogenicity

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12 December 2020

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation

1 reference

12 December 2020

An enzyme from bacteria able to destroy penicillin. 1940.

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12 December 2020

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

1 reference

12 December 2020

Specialized transduction designed for precise high-throughput unmarked deletions in Mycobacterium tuberculosis.

1 reference

12 December 2020

Design, diversity-oriented synthesis and structure activity relationship studies of quinolinyl heterocycles as antimycobacterial agents

1 reference

12 December 2020

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

12 December 2020

Comprehensive transposon mutant library of Pseudomonas aeruginosa

1 reference

12 December 2020

Novel approaches are needed to develop tomorrow's antibacterial therapies

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12 December 2020

A forward chemical screen identifies antibiotic adjuvants in Escherichia coli

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12 December 2020

Is the GAIN Act a turning point in new antibiotic discovery?

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12 December 2020

Genetic interaction maps in Escherichia coli reveal functional crosstalk among cell envelope biogenesis pathways

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12 December 2020

Bacterial phylogeny structures soil resistomes across habitats

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12 December 2020

Impact of high-throughput screening in biomedical research

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12 December 2020

Simultaneous identification of bacterial virulence genes by negative selection.

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12 December 2020

Antibiotics induce redox-related physiological alterations as part of their lethality.

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12 December 2020

Experimental and computational assessment of conditionally essential genes in Escherichia coli

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12 December 2020

Antibiotic sensitivity profiles determined with an Escherichia coli gene knockout collection: generating an antibiotic bar code

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12 December 2020

Ribosome-targeting antibiotics and mechanisms of bacterial resistance.

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12 December 2020

Origins and evolution of antibiotic resistance

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12 December 2020

Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting.

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12 December 2020

Sampling the antibiotic resistome

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12 December 2020

Phenotypic landscape of a bacterial cell

1 reference

12 December 2020

Antibiotics for emerging pathogens

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12 December 2020

New targets and screening approaches in antimicrobial drug discovery

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12 December 2020

Essential Bacillus subtilis genes

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12 December 2020

The antibiotic resistome: what's new?

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12 December 2020

Are essential genes really essential?

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12 December 2020

Essential genome of Pseudomonas aeruginosa in cystic fibrosis sputum

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12 December 2020

Transposon insertion sequencing: a new tool for systems-level analysis of microorganisms.

1 reference

12 December 2020

Classics in infectious diseases: on the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae by Alexander Fleming, Reprinted from the British Journal of Experimental Pathology [...]

1 reference

12 December 2020

ESKAPEing the labyrinth of antibacterial discovery.

1 reference

12 December 2020

Lesions in teichoic acid biosynthesis in Staphylococcus aureus lead to a lethal gain of function in the otherwise dispensable pathway

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12 December 2020

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa

1 reference

12 December 2020

Whole-genome random sequencing and assembly of Haemophilus influenzae Rd

1 reference

12 December 2020

Unconventional screening approaches for antibiotic discovery

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12 December 2020

Privileged structures: efficient chemical "navigators" toward unexplored biologically relevant chemical spaces

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12 December 2020

Persistence of antibiotic resistance in bacterial populations.

1 reference

12 December 2020

The discovery of antibacterial agents using diversity-oriented synthesis

1 reference

12 December 2020

Physicochemical properties of antibacterial compounds: implications for drug discovery

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12 December 2020

Lessons from signature-tagged mutagenesis on the infectious mechanisms of pathogenic bacteria

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12 December 2020

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

1 reference

12 December 2020

The scourge of antibiotic resistance: the important role of the environment

1 reference

12 December 2020

OPT-80, a macrocyclic antimicrobial agent for the treatment of Clostridium difficile infections: a review

1 reference

12 December 2020

A new antibiotic kills pathogens without detectable resistance

1 reference

12 December 2020

Probing teichoic acid genetics with bioactive molecules reveals new interactions among diverse processes in bacterial cell wall biogenesis.

1 reference

12 December 2020

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis.

1 reference

12 December 2020

Antibiotics: Recover the lost art of drug discovery.

1 reference

12 December 2020

Daptomycin: from the mountain to the clinic, with essential help from Francis Tally, MD.

1 reference

12 December 2020

Antibiotic resistance is ancient

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE17042

7 January 2021

inferred from DOI database lookup

An Enzyme from Bacteria able to Destroy Penicillin

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE17042

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NATURE17042

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Dimensions Publication ID

5 September 2017

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