(Q38709364)

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O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate.

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15 March 2020

O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate (English)

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15 March 2020

non-small-cell lung carcinoma

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Muhammad Furqan

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15 March 2020

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15 March 2020

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15 March 2020

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11 June 2022

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based on heuristic

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Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy

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Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture

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Extracellular iron diminishes anticancer effects of vitamin C: an in vitro study

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Iron and cancer: more ore to be mined

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Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial.

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In the absence of catalytic metals ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

23 June 2018

Superoxide ion as a primary reductant in ascorbate-mediated ferritin iron release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

23 June 2018

Design and analysis of phase I clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

23 June 2018

Role of free radicals and catalytic metal ions in human disease: an overview

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

23 June 2018

Production of large amounts of hydrogen peroxide by human tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

23 June 2018

Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

23 June 2018

Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

23 June 2018

Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

31 August 2018

Mitochondrial superoxide mediates labile iron level: evidence from Mn-SOD-transgenic mice and heterozygous knockout mice and isolated rat liver mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

31 August 2018

Altered iron metabolism, inflammation, transferrin receptors, and ferritin expression in non-small-cell lung cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

31 August 2018

2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

31 August 2018

The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

31 August 2018

Fluorescence analysis of the labile iron pool of mammalian cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

31 August 2018

Response criteria for phase II studies of supratentorial malignant glioma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5497844

31 August 2018

Ascorbate autoxidation in the presence of iron and copper chelates

1 reference

https://pubmed.ncbi.nlm.nih.gov/28366679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low oxygen concentration extends the lifespan of cultured human diploid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28366679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative study of the cytoplasmic organelles of epithelial cell lines derived from human carcinomas and nonmalignant tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/28366679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic modeling of ascorbate diffusion through normal and tumor tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/28366679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated titration designs for phase I clinical trials in oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/28366679

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CCELL.2017.02.018

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28366679%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28366679%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28366679%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

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