(Q38719353)

English

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

scientific article published on 26 January 2017

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scholarly article

1 reference

Europe PubMed Central

5 September 2017

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses (English)

1 reference

Europe PubMed Central

5 September 2017

Orthoebolavirus zairense

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1 reference

ChEBI release 2020-05-28

29

object named as

Sina Bavari

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Europe PubMed Central

5 September 2017

Tomáš Cihlář

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Tomas Cihlar

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Europe PubMed Central

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Richard L Mackman

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Richard L Mackman

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Europe PubMed Central

5 September 2017

Veronica Soloveva

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Veronica Soloveva

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Robert Jordan

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Europe PubMed Central

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Dustin S Siegel

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object named as

Dustin Siegel

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Europe PubMed Central

5 September 2017

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Willard Lew

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5 September 2017

Edward Doerffler

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Edward Doerffler

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5 September 2017

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Adrian S Ray

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Michael K Lo

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Roy Bannister

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Europe PubMed Central

5 September 2017

Robert Strickley

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object named as

Robert Strickley

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Ernest Carra

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Queenie Wang

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5 September 2017

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Lydia Wolfe

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Kirsten M Stray

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Kirsten M Stray

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Joy Y Feng

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object named as

Ona Barauskas

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5 September 2017

author name string

Hon C Hui

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5 September 2017

Michael O Clarke

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5 September 2017

Kwon Chun

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5 September 2017

Lijun Zhang

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Sean Neville

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5 September 2017

Bruce Ross

10

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5 September 2017

John Knox

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5 September 2017

Jason Perry

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5 September 2017

Michel Perron

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5 September 2017

Yili Xu

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5 September 2017

Gary Lee

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5 September 2017

Arnold L Rheingold

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Swami Swaminathan

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5 September 2017

William A Lee

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Travis K Warren

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language of work or name

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publication date

26 January 2017

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Europe PubMed Central

5 September 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

5 September 2017

60

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Europe PubMed Central

5 September 2017

5

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5 September 2017

1648-1661

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Europe PubMed Central

5 September 2017

A LiCl-Mediated Br/Mg Exchange Reaction for the Preparation of Functionalized Aryl- and Heteroarylmagnesium Compounds from Organic Bromides

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

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Discovery of β-D-2'-deoxy-2'-α-fluoro-4'-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular evidence of sexual transmission of Ebola virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aryloxy phosphoramidate triesters: a technology for delivering monophosphorylated nucleosides and sugars into cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ebola Virus Shedding and Transmission: Review of Current Evidence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Mechanism of Action of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine Involves a Second Metabolic Pathway Leading to -D-2'-Deoxy-2'-Fluoro-2'-C-Methyluridine 5'-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Filoviruses. A compendium of 40 years of epidemiological, clinical, and laboratory studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-exposure efficacy of oral T-705 (Favipiravir) against inhalational Ebola virus infection in a mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ebola and Marburg haemorrhagic fever.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Directed cell migration on fibronectin gradients: effect of gradient slope.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lipid moiety of brincidofovir is required for in vitro antiviral activity against Ebola virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Late Ebola virus relapse causing meningoencephalitis: a case report

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species difference of esterase expression and hydrolase activity in plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rift Valley fever virus L segment: correction of the sequence and possible functional role of newly identified regions conserved in RNA-dependent polymerases

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular water-specific MR of microbead-adherent cells: the HeLa cell intracellular water exchange lifetime

1 reference

https://pubmed.ncbi.nlm.nih.gov/28124907

12 December 2020

based on heuristic

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Identifiers

10.1021/ACS.JMEDCHEM.6B01594

1 reference

Europe PubMed Central

5 September 2017

1 reference

Europe PubMed Central

5 September 2017

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