(Q38774522)

6 September 2017

Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2. (English)

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6 September 2017

12

Yves Pommier

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6 September 2017

Christophe Marchand

1

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6 September 2017

Monica Abdelmalak

2

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6 September 2017

Jayakanth Kankanala

3

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6 September 2017

Shar-Yin Huang

4

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6 September 2017

Evgeny Kiselev

5

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6 September 2017

Katherine Fesen

6

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6 September 2017

Kayo Kurahashi

7

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6 September 2017

Hiroyuki Sasanuma

8

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6 September 2017

Shunichi Takeda

9

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6 September 2017

Hideki Aihara

10

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6 September 2017

Zhengqiang Wang

11

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6 September 2017

29 April 2016

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6 September 2017

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6 September 2017

11

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6 September 2017

7

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6 September 2017

1925-1933

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A three-dimensional model to analyze drug-drug interactions

6 September 2017

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12 December 2020

Strategic design and three-dimensional analysis of antiviral drug combinations

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12 December 2020

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation

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12 December 2020

EAPII interacts with ETS1 and modulates its transcriptional function

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12 December 2020

A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States

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12 December 2020

Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia

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12 December 2020

The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration

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12 December 2020

A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability

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12 December 2020

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

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12 December 2020

Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway.

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12 December 2020

Mutant p53 cooperates with ETS2 to promote etoposide resistance

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12 December 2020

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

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12 December 2020

Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes

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12 December 2020

An RNA virus hijacks an incognito function of a DNA repair enzyme

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12 December 2020

Mechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2

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12 December 2020

Structural basis for recognition of 5′-phosphotyrosine adducts by Tdp2

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12 December 2020

TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo

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12 December 2020

Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II

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12 December 2020

Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel

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12 December 2020

Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel

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12 December 2020

ATM specifically mediates repair of double-strand breaks with blocked DNA ends

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12 December 2020

TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

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12 December 2020

Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2⋅DNA and Top2⋅RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

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12 December 2020

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).

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12 December 2020

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

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12 December 2020

Alterations of DNA repair genes in the NCI-60 cell lines and their predictive value for anticancer drug activity.

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12 December 2020

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

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12 December 2020

10.1021/ACSCHEMBIO.5B01047

Identifiers

DOI

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6 September 2017

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