(Q38781238)

English

Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells.

scientific article published on 04 April 2016

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27039902%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells (English)

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Europe PubMed Central

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31 March 2020

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Mohammed Bensellam

1

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31 March 2020

5

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31 March 2020

Jean-Christophe Jonas

6

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31 March 2020

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Emma L Maxwell

2

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31 March 2020

Jeng Yie Chan

3

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31 March 2020

Jude Luzuriaga

4

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31 March 2020

Jenny E Gunton

7

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31 March 2020

D Ross Laybutt

8

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31 March 2020

language of work or name

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publication date

4 April 2016

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Europe PubMed Central

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31 March 2020

1 reference

Europe PubMed Central

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31 March 2020

59

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31 March 2020

7

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Europe PubMed Central

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31 March 2020

1492-1502

1 reference

Europe PubMed Central

PubMed publication ID

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31 March 2020

https://scigraph.springernature.com/pub.10.1007/s00125-016-3947-y

0 references

Regulation of insulin secretion: role of mitochondrial signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct cytoplasmic and nuclear functions of the stress induced protein DDIT3/CHOP/GADD153

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HDLs protect pancreatic β-cells against ER stress by restoring protein folding and trafficking

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular mechanisms of pancreatic β-cell glucotoxicity: recent findings and future research directions

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER stress in rodent islets of Langerhans is concomitant with obesity and β-cell compensation but not with β-cell dysfunction and diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factors in physiology and medicine

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role for endoplasmic reticulum stress in diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic β-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Moderate hypoxia induces β-cell dysfunction with HIF-1-independent gene expression changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER-to-Golgi transport visualized in living cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased numbers of low-oxygenated pancreatic islets after intraportal islet transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress and pancreatic β-cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor-1α (HIF-1α) potentiates β-cell survival after islet transplantation of human and mouse islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of PKR impairs angiogenesis through a VEGF pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant islet unfolded protein response in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia response and microRNAs: no longer two separate worlds.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factors Influencing the Loss of β-Cell Mass in Islet Transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of G(1) arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant-mitochondrial response in mouse beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-Jun N-terminal kinase JNK participates in cytokine- and isolation stress-induced rat pancreatic islet apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27039902

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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