(Q39562673)

English

Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells

scientific article published on 7 April 2011

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scholarly article

1 reference

Europe PubMed Central

13 September 2017

Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells (English)

1 reference

Europe PubMed Central

13 September 2017

apoptotic process

0 references

author name string

J Y Chan

1

1 reference

Europe PubMed Central

13 September 2017

G J Cooney

2

1 reference

Europe PubMed Central

13 September 2017

T J Biden

3

1 reference

Europe PubMed Central

13 September 2017

D R Laybutt

4

1 reference

Europe PubMed Central

13 September 2017

publication date

7 April 2011

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

54

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Europe PubMed Central

13 September 2017

7

1 reference

Europe PubMed Central

13 September 2017

1766-1776

1 reference

Europe PubMed Central

13 September 2017

https://scigraph.springernature.com/pub.10.1007/s00125-011-2139-z

0 references

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[25] Nitric-oxide synthase assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Balancing reactivity against selectivity: the evolution of protein S-nitrosylation as an effector of cell signaling by nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for activating transcription factor 3 in stress-induced beta-cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role for endoplasmic reticulum stress in diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta cell apoptosis in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal integration in the endoplasmic reticulum unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cytokines in the pathogenesis of autoimmune diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of inflammation in insulitis and beta-cell loss in type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide and the regulation of gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPARgamma ligands induce ER stress in pancreatic beta-cells: ER stress activation results in attenuation of cytokine signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A time-dependent phase shift in the mammalian unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From acute ER stress to physiological roles of the Unfolded Protein Response

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21472432

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-011-2139-Z

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

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