(Q38795816)

English

Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT)

scientific article published on June 2004

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT) (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

author name string

A Mayer

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

S K Sharma

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

B Tolner

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

D Purdy

5

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

P Amlot

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

G Tharakan

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

R H J Begent

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

K A Chester

9

1 reference

Europe PubMed Central

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28 December 2019

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publication date

1 June 2004

1 reference

Europe PubMed Central

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28 December 2019

British Journal of Cancer

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

90

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Europe PubMed Central

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28 December 2019

12

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

2402-2410

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Minimizing the immunogenicity of protein therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

6 September 2017

Renaissance of cancer therapeutic antibodies

1 reference

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6 September 2017

Preliminary report of a phase I study of combination chemotherapy and humanized A33 antibody immunotherapy in patients with advanced colorectal cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

6 September 2017

Engineered antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

6 September 2017

A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

6 September 2017

The danger model: a renewed sense of self

1 reference

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6 September 2017

Improving the efficacy of antibody-based cancer therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

6 September 2017

Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

6 September 2017

Antibody-directed enzyme prodrug therapy: efficacy and mechanism of action in colorectal carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

6 September 2017

Biochemical modifications of avidin improve pharmacokinetics and biodistribution, and reduce immunogenicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

6 September 2017

In vitro and in vivo characterisation of a recombinant carboxypeptidase G2::anti-CEA scFv fusion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

6 September 2017

MOLMOL: a program for display and analysis of macromolecular structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

6 September 2017

Phage libraries for generation of clinically useful antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

6 September 2017

Man-made antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

6 September 2017

Radioimmunoguided surgery in colorectal cancer using a genetically engineered anti-CEA single-chain Fv antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

14 September 2017

Phase I evaluation of humanized OKT3: toxicity and immunomodulatory effects of hOKT3gamma4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

14 September 2017

Staphylokinase-specific cell-mediated immunity in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

25 September 2017

A strategy for mapping and neutralizing conformational immunogenic sites on protein therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

22 June 2018

Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

22 June 2018

Erwinia chrysanthemi L-asparaginase: epitope mapping and production of antigenically modified enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

22 June 2018

The complete nucleotide sequence of the Pseudomonas gene coding for carboxypeptidase G2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

22 June 2018

A cytotoxic agent can be generated selectively at cancer sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

22 June 2018

Antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase A1: in vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibitors GW1031 and GW1843.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

31 August 2018

Human immune response to monoclonal antibody-enzyme conjugates in ADEPT pilot clinical trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2409521

1 October 2018

Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6601888

21 January 2018

Catalytic activity of an in vivo tumor targeted anti-CEA scFv::carboxypeptidase G2 fusion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15162148

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative position of the hexahistidine tag effects binding properties of a tumor-associated single-chain Fv construct

1 reference

https://pubmed.ncbi.nlm.nih.gov/15162148

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimisation of small-scale coupling of A5B7 monoclonal antibody to carboxypeptidase G2

1 reference

https://pubmed.ncbi.nlm.nih.gov/15162148

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification of bacterially expressed single chain Fv antibodies for clinical applications using metal chelate chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/15162148

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of cyclosporine on immunogenicity of a bacterial enzyme carboxypeptidase G2 in ADEPT

1 reference

https://pubmed.ncbi.nlm.nih.gov/15162148

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant staphylokinase variants with altered immunoreactivity. IV: Identification of variants with reduced antibody induction but intact potency

1 reference

https://pubmed.ncbi.nlm.nih.gov/15162148

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-alpha) in normal and transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15162148

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)

1 reference

https://pubmed.ncbi.nlm.nih.gov/15162148

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJC.6601888

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Dimensions Publication ID

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1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15162148%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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