(Q38814573)

6 September 2017

Scutellarin as a Potential Therapeutic Agent for Microglia-Mediated Neuroinflammation in Cerebral Ischemia (English)

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6 September 2017

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Yun Yuan

1

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6 September 2017

Ming Fang

series ordinal

2

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6 September 2017

Chun-Yun Wu

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3

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6 September 2017

Eng-Ang Ling

series ordinal

4

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6 September 2017

21 April 2016

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6 September 2017

NeuroMolecular Medicine

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6 September 2017

18

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6 September 2017

264-273

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6 September 2017

3

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https://scigraph.springernature.com/pub.10.1007/s12017-016-8394-x

6 September 2017

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cites work

Post-ischemic brain damage: pathophysiology and role of inflammatory mediators.

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Astrocytes and stroke: networking for survival?

21 January 2018

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Notch and NFkappaB signaling pathways: Do they collaborate in normal vertebrate brain development and function?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Role of the pro-inflammatory cytokines TNF-alpha and IL-1beta in HIV-associated dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Nuclear factor-κB/p65 responds to changes in the Notch signaling pathway in murine BV-2 cells and in amoeboid microglia in postnatal rats treated with the γ-secretase complex blocker DAPT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Expression of Notch-1 receptor and its ligands Jagged-1 and Delta-1 in amoeboid microglia in postnatal rat brain and murine BV-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Scutellarin and caffeic acid ester fraction, active components of Dengzhanxixin injection, upregulate neurotrophins synthesis and release in hypoxia/reoxygenation rat astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Scutellarin attenuates hypertension-induced expression of brain Toll-like receptor 4/nuclear factor kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Vascular inflammatory, oxidative and protease-based processes: implications for neuronal cell death in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

The yin and yang of microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Heterogeneity in the penumbra

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Proliferating resident microglia after focal cerebral ischaemia in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Microglial activation and its implications in the brain diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Brain inflammation and adult neurogenesis: the dual role of microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Novel function of scutellarin in inhibiting cell proliferation and inducing cell apoptosis of human Burkitt lymphoma Namalwa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

The neurotoxicity of β-amyloid peptide toward rat brain is associated with enhanced oxidative stress, inflammation and apoptosis, all of which can be attenuated by scutellarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Scutellarin protects against Aβ-induced learning and memory deficits in rats: involvement of nicotinic acetylcholine receptors and cholinesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Neuroprotective effects of scutellarin against hypoxic-ischemic-induced cerebral injury via augmentation of antioxidant defense capacity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

In vitro inhibitory effects of scutellarin on six human/rat cytochrome P450 enzymes and P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by scutellarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Pathophysiology and therapy of experimental stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Determination of aglycone conjugated metabolites of scutellarin in rat plasma by HPLC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Inflammation in stroke and focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Effects of cortical ischemia and postischemic environmental enrichment on hippocampal cell genesis and differentiation in the adult rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Microglia in cerebral ischemia: molecular actions and interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Microglia protect neurons against ischemia by synthesis of tumor necrosis factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Scutellarin inhibits the growth and invasion of human tongue squamous carcinoma through the inhibition of matrix metalloproteinase-2 and -9 and αvβ6 integrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Scutellarin's Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-Iα

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Functional Recovery after Scutellarin Treatment in Transient Cerebral Ischemic Rats: A Pilot Study with (18) F-Fluorodeoxyglucose MicroPET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Suppression of diet-induced hypercholesterolemia by scutellarin in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

The origin and nature of ramified and amoeboid microglia: a historical review and current concepts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Effect of scutellarin on nitric oxide production in early stages of neuron damage induced by hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

N9 microglial cells polarized by LPS and IL4 show differential responses to secondary environmental stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Protective effects of scutellarin on type II diabetes mellitus-induced testicular damages related to reactive oxygen species/Bcl-2/Bax and reactive oxygen species/microcirculation/staving pathway in diabetic rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Phagocytosis executes delayed neuronal death after focal brain ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Debris clearance by microglia: an essential link between degeneration and regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as "continuum" phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Scutellarin exerts its anti-hypertrophic effects via suppressing the Ca2+-mediated calcineurin and CaMKII signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Focal cerebral ischemia in the TNFalpha-transgenic rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Microglia expressing interleukin-13 undergo cell death and contribute to neuronal survival in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Interleukin-1 and inflammatory neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Interleukin-6, a mental cytokine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Divergent roles for tumor necrosis factor-alpha in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Delayed neural network degeneration after neonatal hypoxia-ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Blockade of microglial glutamate release protects against ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Comparative Metabolomic Analysis of the Neuroprotective Effects of Scutellarin and Scutellarein against Ischemic Insult

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Na+ channels as targets for neuroprotective drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Systemic inflammation exacerbates behavioral and histopathological consequences of isolated traumatic brain injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

The inflammatory response in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Scutellarin inhibits high glucose-induced and hypoxia-mimetic agent-induced angiogenic effects in human retinal endothelial cells through reactive oxygen species/hypoxia-inducible factor-1α/vascular endothelial growth factor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Neuroprotection of Scutellarin is mediated by inhibition of microglial inflammatory activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

MRI monitoring of neuroinflammation in mouse focal ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Notch signaling in the central nervous system with special reference to its expression in microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Notch-1 signaling regulates microglia activation via NF-κB pathway after hypoxic exposure in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

A new and efficient synthesis of 6-O-methylscutellarein, the major metabolite of the natural medicine scutellarin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Protective effects of scutellarin against cerebral ischemia in rats: evidence for inhibition of the apoptosis-inducing factor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

TGFβ signalling plays an important role in IL4-induced alternative activation of microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Estrogenic and neuroprotective properties of scutellarin from Erigeron breviscapus: a drug against postmenopausal symptoms and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-016-8394-X

Brain macrophages: evaluation of microglia and their functions

21 January 2018

1 reference

12 December 2020

Effects of scutellarin on apoptosis induced by cobalt chloride in PC12 cells.

1 reference

12 December 2020

Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation

1 reference

12 December 2020

Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage

1 reference

12 December 2020

Scutellarin-induced apoptosis in HepG2 hepatocellular carcinoma cells via a STAT3 pathway

1 reference

12 December 2020

Acute and subacute toxicological evaluation of scutellarin in rodents

1 reference

12 December 2020

[The beta-amyloid cascade hypothesis: a sequence of events leading to neurodegeneration in Alzheimer's disease].

1 reference

12 December 2020

Scutellarin blocks sodium current in freshly isolated mouse hippocampal CA1 neurons

1 reference

12 December 2020

Transformation of amoeboid microglial cells into microglia in the corpus callosum of the postnatal rat brain. An electron microscopical study

1 reference

12 December 2020

Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice

1 reference

12 December 2020

Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics.

1 reference

12 December 2020

Quantitative changes in interleukin proteins following focal stroke in the rat

1 reference

12 December 2020

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1 reference

12 December 2020

10.1007/S12017-016-8394-X

Identifiers

DOI

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Dimensions Publication ID

6 September 2017

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