(Q38828275)

6 September 2017

title

Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies (English)

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11

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Simone Brogi

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Samuele Maramai

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Samuele Maramai

6

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Stefania Butini

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Stefania Butini

9

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Manfred Jung

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Manfred Jung

13

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author name string

Margherita Brindisi

1

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6 September 2017

Caterina Cavella

2

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6 September 2017

Angela Nebbioso

4

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6 September 2017

Johanna Senger

5

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6 September 2017

Alfonso Ciotta

7

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Concetta Iside

8

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6 September 2017

Stefania Lamponi

10

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6 September 2017

Lucia Altucci

12

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6 September 2017

Giuseppe Campiani

14

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6 September 2017

Sandra Gemma

15

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6 September 2017

publication date

24 August 2016

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Future Medicinal Chemistry

6 September 2017

published in

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6 September 2017

volume

8

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6 September 2017

issue

13

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6 September 2017

page(s)

1573-1587

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Chromatin modifications and their function

6 September 2017

cites work

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https://api.crossref.org/works/10.4155%2FFMC-2016-0068

Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

21 January 2018

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Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

21 January 2018

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The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC-2016-0068

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

21 January 2018

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HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

21 January 2018

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HDAC6 modulates cell motility by altering the acetylation level of cortactin

21 January 2018

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HDAC6 is a microtubule-associated deacetylase

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC-2016-0068

Development of a histone deacetylase 6 inhibitor and its biological effects

21 January 2018

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Drugging the HDAC6-HSP90 interplay in malignant cells.

21 January 2018

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Heat shock protein 90 - a potential target in the treatment of human acute myelogenous leukemia

21 January 2018

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The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

21 January 2018

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HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

21 January 2018

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The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response

21 January 2018

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Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.

21 January 2018

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HDAC isoenzyme expression is deregulated in chronic lymphocytic leukemia B-cells and has a complex prognostic significance

21 January 2018

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Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma

21 January 2018

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Development and therapeutic impact of HDAC6-selective inhibitors

21 January 2018

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Inhibitors of HDACs--effective drugs against cancer?

21 January 2018

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Exploiting epigenetic vulnerabilities for cancer therapeutics

21 January 2018

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PCI-24781 (abexinostat), a novel histone deacetylase inhibitor, induces reactive oxygen species-dependent apoptosis and is synergistic with bortezomib in neuroblastoma

21 January 2018

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A stereoselective approach to peptidomimetic BACE1 inhibitors.

21 January 2018

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Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.

21 January 2018

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Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors.

21 January 2018

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Rational design of the first difluorostatone-based PfSUB1 inhibitors

21 January 2018

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Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand

21 January 2018

1 reference

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Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0068

In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0068

Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.

21 January 2018

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Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties

21 January 2018

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In vitro assays for the determination of histone deacetylase activity

21 January 2018

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A fluorogenic histone deacetylase assay well suited for high-throughput activity screening

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0068

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0068

Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0068

A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC-2016-0068

I-TASSER: a unified platform for automated protein structure and function prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0068

Discovery and cardioprotective effects of the first non-Peptide agonists of the G protein-coupled prokineticin receptor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0068

Tacrine based human cholinesterase inhibitors: Synthesis of peptidic-tethered derivatives and their effect on potency and selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0068

Plasmodium falciparum subtilisin-like protease 1: discovery of potent difluorostatone-based inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0068

From (+)-epigallocatechin gallate to a simplified synthetic analogue as a cytoadherence inhibitor for P. falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0068

21 January 2018

Identifiers

DOI

10.4155/FMC-2016-0068

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6 September 2017

1 reference