(Q38829813)

6 September 2017

title

Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression (English)

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6 September 2017

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Ayumu Nakashima

5

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Koji Arihiro

8

object named as

Koji Arihiro

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6 September 2017

Taisuke Irifuku

1

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6 September 2017

Shigehiro Doi

2

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6 September 2017

Kensuke Sasaki

3

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6 September 2017

Toshiki Doi

4

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6 September 2017

Toshinori Ueno

6

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6 September 2017

Kyoko Yamada

7

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6 September 2017

Nobuoki Kohno

9

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6 September 2017

Takao Masaki

10

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6 September 2017

language of work or name

English

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publication date

7 October 2015

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6 September 2017

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6 September 2017

volume

89

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6 September 2017

issue

1

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6 September 2017

page(s)

147-157

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Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization

6 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Microalbuminuria as predictor of increased mortality in elderly people

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https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

A population-based study of the incidence and outcomes of diagnosed chronic kidney disease

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https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Serum Creatinine Concentration and Risk of Cardiovascular Disease

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https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Cardiovascular disease and mortality in a community-based cohort with mild renal insufficiency

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https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Association of renal insufficiency with treatment and outcomes after myocardial infarction in elderly patients

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https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Mechanisms of tubulointerstitial injury in the kidney: final common pathways to end-stage renal failure

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https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Tubulointerstitial changes as a major determinant in the progression of renal damage

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Structural-functional correlations in renal disease. II. The correlations.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Cellular and molecular mechanisms of fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Molecular basis of renal fibrosis

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https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Renal fibrosis: new insights into the pathogenesis and therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Origin and function of myofibroblasts in kidney fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Chronic kidney disease progression.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

TGF-beta signal transduction in chronic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Angiotensin II as a morphogenic cytokine stimulating renal fibrogenesis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Signal transduction by the TGF-beta superfamily

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Suppression of aging in mice by the hormone Klotho

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Augmented Wnt signaling in a mammalian model of accelerated aging

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Severely reduced production of klotho in human chronic renal failure kidney.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Secreted klotho and chronic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Stability and flexibility of epigenetic gene regulation in mammalian development

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Transposable elements and the epigenetic regulation of the genome

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

BIX-01294 treatment blocks cell proliferation, migration and contractility in ovine foetal pulmonary arterial smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Epigenetic silencing of the tumor suppressor klotho in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Histone lysine demethylases: emerging roles in development, physiology and disease

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Histone methyltransferases in cancer

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Translating the Histone Code

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

The TAK1-TRAF6 signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-β1 signaling

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

15-Deoxy-Delta12,14-prostaglandin J2 inhibits angiotensin II-induced fibronectin expression via hepatocyte growth factor induction in human peritoneal mesothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2015.291

7 January 2021

Identifiers

DOI

10.1038/KI.2015.291

1 reference

Dimensions Publication ID

6 September 2017

1014096318

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1 reference