(Q38830118)

6 September 2017

1 reference

title

Exercise for the diabetic brain: how physical training may help prevent dementia and Alzheimer's disease in T2DM patients (English)

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6 September 2017

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1 reference

Sebastian Bertram

1

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6 September 2017

Klara Brixius

series ordinal

2

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6 September 2017

Christian Brinkmann

series ordinal

3

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6 September 2017

publication date

9 May 2016

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6 September 2017

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6 September 2017

volume

53

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6 September 2017

issue

2

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6 September 2017

page(s)

350-363

1 reference

https://scigraph.springernature.com/pub.10.1007/s12020-016-0976-8

6 September 2017

exact match

0 references

cites work

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Activation of protein kinase C isoforms and its impact on diabetic complications

21 January 2018

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Platelet dysfunction in type 2 diabetes

21 January 2018

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Efficacy of fibrates for cardiovascular risk reduction in persons with atherogenic dyslipidemia: a meta-analysis

21 January 2018

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Adipokines in inflammation, insulin resistance and cardiovascular disease

21 January 2018

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Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies

21 January 2018

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IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation

21 January 2018

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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity

21 January 2018

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The role of insulin in human brain glucose metabolism: an 18fluoro-deoxyglucose positron emission tomography study

21 January 2018

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Metabolic Alterations Associated to Brain Dysfunction in Diabetes

21 January 2018

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

21 January 2018

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Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

21 January 2018

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Glucose metabolism in normal aging and Alzheimer's disease: Methodological and physiological considerations for PET studies

21 January 2018

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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

21 January 2018

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Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence

21 January 2018

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Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment

21 January 2018

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Insulin has multiple antiamyloidogenic effects on human neuronal cells

21 January 2018

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21 January 2018

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Neuropathological alterations in Alzheimer disease

21 January 2018

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Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.

21 January 2018

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Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

21 January 2018

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Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Growth hormone, insulin-like growth factor-1 and the aging brain.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Alzheimer's disease and insulin resistance: translating basic science into clinical applications

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Relationship between obesity, adipocytokines and inflammatory markers in type 2 diabetes: relevance for cardiovascular risk prevention

21 January 2018

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Inflammatory Markers in Obese Adolescents with Type 2 Diabetes and Their Relationship to Hepatokines and Adipokines

21 January 2018

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Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

21 January 2018

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Increased serum IL-1beta level in Alzheimer's disease and mild cognitive impairment.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients

21 January 2018

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IKK-beta links inflammation to obesity-induced insulin resistance

21 January 2018

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Attenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet.

21 January 2018

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21 January 2018

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Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model

21 January 2018

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Different patterns of cerebral injury in dementia with or without diabetes

21 January 2018

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Obesity and dementia: adipokines interact with the brain.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Reactive oxygen species generation in peripheral blood monocytes and oxidized LDL are increased in hyperlipidemic patients

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Advanced glycation end products: sparking the development of diabetic vascular injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Ceramide-Mediated Insulin Resistance and Impairment of Cognitive-Motor Functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Systemic catabolism of Alzheimer's Abeta40 and Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Cerebral clearance of human amyloid-beta peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Insulin facilitates the hepatic clearance of plasma amyloid beta-peptide (1 40) by intracellular translocation of low-density lipoprotein receptor-related protein 1 (LRP-1) to the plasma membrane in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Low testosterone levels are common and associated with insulin resistance in men with diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Effects of testosterone treatment on glucose metabolism and symptoms in men with type 2 diabetes and the metabolic syndrome: a systematic review and meta-analysis of randomized controlled clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Testosterone effect on brain metabolism in elderly patients with Alzheimer's disease: comparing two cases at different disease stages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Effect of exercise intervention on endothelial function and incidence of cardiovascular disease in patients with type 2 diabetes

21 January 2018

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Improved endothelial function following a 14-month resistance exercise training program in adults with type 2 diabetes

21 January 2018

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Effects of endurance training on blood pressure, blood pressure-regulating mechanisms, and cardiovascular risk factors

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Effects of supervised exercise on lipid profiles and blood pressure control in people with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Effects of long-term exercise on spatial learning, memory ability, and cortical capillaries in aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Is physical activity a potential preventive factor for vascular dementia? A systematic review

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

The effect of a community-based, primary health care exercise program on inflammatory biomarkers and hormone levels

21 January 2018

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The neuropathology of sport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Changes in tumor necrosis factor-alpha system and insulin sensitivity during an exercise training program in obese women with normal and impaired glucose tolerance

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Effects of diet and/or exercise on the adipocytokine and inflammatory cytokine levels of postmenopausal women with type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Exercise training attenuates oxidative stress and decreases p53 protein content in skeletal muscle of type 2 diabetic Goto-Kakizaki rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Moderate exercise is an antioxidant: upregulation of antioxidant genes by training.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Modulation of skeletal muscle antioxidant defense by exercise: Role of redox signaling

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Aerobic exercise training improves the role of high-density lipoprotein antioxidant and reduces plasma lipid peroxidation in type 2 diabetes mellitus

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Effects of regular exercise on cardiovascular risk factors profile and oxidative stress in obese type 2 diabetic patients in regard to SCORE risk

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Effect of a diet and exercise intervention on oxidative stress, inflammation and monocyte adhesion in diabetic men.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Effect of caloric restriction with and without exercise training on oxidative stress and endothelial function in obese subjects with type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Single bout of exercise eliminates the immobilization-induced oxidative stress in rat brain

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

The dose-dependent antioxidant effects of physical exercise in the hippocampus of mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Voluntary exercise promotes beneficial anti-aging mechanisms in SAMP8 female brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer's disease (APP/PS1) transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Endogenous anabolic hormone responses to endurance versus resistance exercise and training in women

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Does high-intensity resistance training maintain bone mass during moderate weight loss in older overweight adults with type 2 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Exercise builds brain health: key roles of growth factor cascades and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Be smart, exercise your heart: exercise effects on brain and cognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

The effects of physical activity and exercise on brain-derived neurotrophic factor in healthy humans: A review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Brain-derived neurotrophic factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

BDNF mediates adaptive brain and body responses to energetic challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Muscles and their myokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Brain-derived neurotrophic factor in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Evidence for a release of brain-derived neurotrophic factor from the brain during exercise.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Exercise training increases size of hippocampus and improves memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Aerobic exercise increases hippocampal volume in older women with probable mild cognitive impairment: a 6-month randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Exercise and type 2 diabetes: American College of Sports Medicine and the American Diabetes Association: joint position statement. Exercise and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Effects of heavy endurance physical exercise on inflammatory markers in non-athletes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12020-016-0976-8

Effect of chronic regular exercise on serum ischemia-modified albumin levels and oxidative stress in type 2 diabetes mellitus

21 January 2018

1 reference

12 December 2020

Cerebral small vessel disease and Alzheimer's disease

1 reference

12 December 2020

Chronic aerobic exercise associated to dietary modification improve endothelial function and eNOS expression in high fat fed hamsters

1 reference

12 December 2020

Lipid mediators of insulin resistance

1 reference

12 December 2020

Midlife vascular risk factors and the risk of Alzheimer's disease: a systematic review and meta-analysis

1 reference

12 December 2020

Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment

1 reference

12 December 2020

Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice

1 reference

12 December 2020

Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewed

1 reference

12 December 2020

Epigenetic Regulatory Effect of Exercise on Glutathione Peroxidase 1 Expression in the Skeletal Muscle of Severely Dyslipidemic Mice.

1 reference

12 December 2020

Insulin resistance, metabolic stress, and atherosclerosis

1 reference

12 December 2020

The JNK signal transduction pathway

1 reference

12 December 2020

Diabetes mellitus and dementia - a systematic review and meta-analysis

1 reference

12 December 2020

Insulin signaling in the central nervous system: learning to survive

1 reference

12 December 2020

Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal

1 reference

12 December 2020

Risk factors for predicting progression from mild cognitive impairment to Alzheimer's disease: a systematic review and meta-analysis of cohort studies

1 reference

12 December 2020

Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA2 inhibitor darapladib

1 reference

12 December 2020

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

1 reference

12 December 2020

Aberrant insulin signaling in Alzheimer's disease: current knowledge

1 reference

12 December 2020

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease

1 reference

12 December 2020

Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain.

1 reference

12 December 2020

Cerebrospinal fluid interleukin-1 beta (IL-1 beta) in Alzheimer's disease and neurological disorders

1 reference

12 December 2020

Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy

1 reference

12 December 2020

Serum total testosterone is lower in men with Alzheimer's disease.

1 reference

12 December 2020

10.1007/S12020-016-0976-8

Identifiers

DOI

1 reference

6 September 2017

1 reference